Role of Jak kinases and STATs in cytokine signal transduction (Q34246712)

31 July 2017

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title

Role of Jak kinases and STATs in cytokine signal transduction (English)

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31 July 2017

W J Leonard

1

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publication date

1 April 2001

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International Journal of Hematology

31 July 2017

published in

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volume

73

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issue

3

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page(s)

271-277

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Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines.

31 July 2017

cites work

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12 December 2020

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites

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12 December 2020

Jak-STAT signaling induced by the v-abl oncogene

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12 December 2020

Molecular characterization of the signal responsible for the targeting of the interleukin 2 receptor beta chain toward intracellular degradation

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12 December 2020

The significance of tetramerization in promoter recruitment by Stat5.

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12 December 2020

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

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12 December 2020

Modulation of STAT signaling by STAT-interacting proteins

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12 December 2020

Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway

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12 December 2020

Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses

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12 December 2020

Negative regulation of cytokine signaling pathways

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12 December 2020

Immune response in Stat2 knockout mice

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12 December 2020

Jaks and STATs: biological implications

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12 December 2020

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

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12 December 2020

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

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12 December 2020

Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

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12 December 2020

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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12 December 2020

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

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12 December 2020

Structure of the amino-terminal protein interaction domain of STAT-4

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12 December 2020

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

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12 December 2020

Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling

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12 December 2020

Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity

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12 December 2020

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

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12 December 2020

Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function

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12 December 2020

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells

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12 December 2020

The state of the STATs: recent developments in the study of signal transduction to the nucleus

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12 December 2020

DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites

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12 December 2020

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

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12 December 2020

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue

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12 December 2020

Both stat5a and stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue

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12 December 2020

Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha

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12 December 2020

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

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12 December 2020

Serine phosphorylation of STATs

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12 December 2020

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

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12 December 2020

Roles of STAT3 defined by tissue-specific gene targeting

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12 December 2020

Partial impairment of cytokine responses in Tyk2-deficient mice

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12 December 2020

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

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12 December 2020

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

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12 December 2020

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

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12 December 2020

An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction

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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

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Jak2 is essential for signaling through a variety of cytokine receptors

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Inhibitors keep cytokines in check

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Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

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STATs and gene regulation

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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

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Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

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12 December 2020

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

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Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons

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Preface: STAT signaling

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12 December 2020

Identifiers

DOI

10.1007/BF02981951

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Dimensions Publication ID

31 July 2017

1029754831

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