Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast (Q34246922)

31 July 2017

Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast (English)

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31 July 2017

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7

Piotr Mieczkowski

1 reference

31 July 2017

He Gong

1

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31 July 2017

Nina V Romanova

2

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31 July 2017

Kim D Allen

3

1 reference

31 July 2017

Pavithra Chandramowlishwaran

4

1 reference

31 July 2017

Kavita Gokhale

5

1 reference

31 July 2017

Gary P Newnam

6

1 reference

31 July 2017

Michael Y Sherman

8

1 reference

31 July 2017

Yury O Chernoff

9

1 reference

31 July 2017

19 April 2012

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31 July 2017

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31 July 2017

8

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31 July 2017

4

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31 July 2017

e1002634

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Creative Commons Attribution 4.0 International

31 July 2017

start time

19 April 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Polyglutamine misfolding in yeast: toxic and protective aggregation

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Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

6 July 2018

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Huntington's disease: from molecular pathogenesis to clinical treatment

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Recruitment of the oncoprotein v-ErbA to aggresomes.

6 July 2018

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The ubiquitous role of ubiquitin in the DNA damage response

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Neurotoxic protein oligomerisation associated with polyglutamine diseases

6 July 2018

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Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction

6 July 2018

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Repeat expansion disease: progress and puzzles in disease pathogenesis

6 July 2018

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Interdependence of amyloid formation in yeast: implications for polyglutamine disorders and biological functions

6 July 2018

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Parkin-mediated ubiquitin signalling in aggresome formation and autophagy

6 July 2018

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Sequestration of essential proteins causes prion associated toxicity in yeast

6 July 2018

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Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis

6 July 2018

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Huntingtin as an essential integrator of intracellular vesicular trafficking

6 July 2018

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Biological roles of prion domains

6 July 2018

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Yeast prions: evolution of the prion concept

6 July 2018

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The yeast Sup35NM domain propagates as a prion in mammalian cells

6 July 2018

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Screening for amyloid aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery

6 July 2018

1 reference

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Misfolded proteins partition between two distinct quality control compartments

6 July 2018

1 reference

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Double-strand breaks associated with repetitive DNA can reshape the genome

6 July 2018

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Aggresome formation and neurodegenerative diseases: therapeutic implications

6 July 2018

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Polyglutamine diseases: emerging concepts in pathogenesis and therapy

6 July 2018

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Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Endocytosis machinery is involved in aggregation of proteins with expanded polyglutamine domains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Eukaryotic release factor 1 phosphorylation by CK2 protein kinase is dynamic but has little effect on the efficiency of translation termination in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Flanking sequences profoundly alter polyglutamine toxicity in yeast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

A network of protein interactions determines polyglutamine toxicity

6 July 2018

1 reference

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The delitto perfetto approach to in vivo site-directed mutagenesis and chromosome rearrangements with synthetic oligonucleotides in yeast

6 July 2018

1 reference

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A method for calling gains and losses in array CGH data

6 July 2018

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Hsp70 chaperones as modulators of prion life cycle: novel effects of Ssa and Ssb on the Saccharomyces cerevisiae prion [PSI+]

6 July 2018

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Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Protein aggregation and neurodegenerative disease

6 July 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

6 July 2018

1 reference

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Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

6 July 2018

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Propagation of yeast prions.

6 July 2018

1 reference

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Aggregation of expanded polyglutamine domain in yeast leads to defects in endocytosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Ubiquitin-dependent degradation of the yeast Mat(alpha)2 repressor enables a switch in developmental state

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Mouse GSPT2, but not GSPT1, can substitute for yeast eRF3 in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Getting started with yeast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Hassles with taking out the garbage: aggravating aggresomes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Aggresomes, inclusion bodies and protein aggregation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Polyglutamine diseases: protein cleavage and aggregation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Polyglutamine pathogenesis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Aggresomes: a cellular response to misfolded proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Exploring the metabolic and genetic control of gene expression on a genomic scale

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Cell cycle regulation by the ubiquitin pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Quantitation of readthrough of termination codons in yeast using a novel gene fusion assay

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Interaction of the yeast omnipotent suppressors SUP1(SUP45) and SUP2(SUP35) with non-mendelian factors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334884

Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice

6 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002634

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002634

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002634

Modulation of prion-dependent polyglutamine aggregation and toxicity by chaperone proteins in the yeast model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002634

Yeast polypeptide chain release factors eRF1 and eRF3 are involved in cytoskeleton organization and cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002634

Yeast 2 microm plasmid copy number is elevated by a mutation in the nuclear gene UBC4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002634

Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002634

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002634

Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002634

Yeast prion [psi +] and its determinant, Sup35p

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1002634

The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks

21 January 2018

1 reference

12 December 2020

Effects of ubiquitin system alterations on the formation and loss of a yeast prion

1 reference

12 December 2020

Evolutionary conservation of prion-forming abilities of the yeast Sup35 protein

1 reference

12 December 2020

[Characterization of missense mutations in the SUP45 gene of Saccharomyces cerevisiae encoding translation termination factor eRF1]

1 reference

12 December 2020

Deletion analysis of the SUP35 gene of the yeast Saccharomyces cerevisiae reveals two non-overlapping functional regions in the encoded protein

1 reference

12 December 2020

10.1371/JOURNAL.PGEN.1002634

Identifiers

DOI

1 reference

31 July 2017

1 reference

31 July 2017

1 reference