Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line. (Q34258443)

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15 February 2020

title

Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line (English)

1 reference

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15 February 2020

1 reference

dasatinib monohydrate

1 reference

1 reference

3

1 reference

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15 February 2020

Patrizia Casalini

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20955590%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Italia Bongarzone

6

1 reference

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15 February 2020

author name string

Dario Caccia

1

1 reference

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15 February 2020

Francesca Miccichè

2

1 reference

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15 February 2020

Piera Mondellini

4

1 reference

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15 February 2020

publication date

18 October 2010

1 reference

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15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20955590%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

volume

9

1 reference

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15 February 2020

page(s)

278

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20955590%20AND%20SRC:MED&resulttype=core&format=json

Inhibition of p-STAT3 enhances IFN-alpha efficacy against metastatic melanoma in a murine model.

15 February 2020

cites work

1 reference

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LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer

28 July 2018

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Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib.

28 July 2018

1 reference

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Signal integration by JNK and p38 MAPK pathways in cancer development

28 July 2018

1 reference

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Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cells

28 July 2018

1 reference

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Signal transduction by focal adhesion kinase in cancer

28 July 2018

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Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation

28 July 2018

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Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells

28 July 2018

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The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting

28 July 2018

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Proteomics study of medullary thyroid carcinomas expressing RET germ-line mutations: identification of new signaling elements.

28 July 2018

1 reference

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BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells

28 July 2018

1 reference

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ANTI-ADHESION evolves to a promising therapeutic concept in oncology

28 July 2018

1 reference

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RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2967544

Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival

28 July 2018

1 reference

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Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration

28 July 2018

1 reference

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Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway

28 July 2018

1 reference

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Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells

28 July 2018

1 reference

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Direct phosphorylation of proliferative and survival pathway proteins by RET.

28 July 2018

1 reference

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Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2967544

Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo.

28 July 2018

1 reference

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Paxillin: a focal adhesion-associated adaptor protein

28 July 2018

1 reference

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Origin and progression of thyroid epithelial tumours: cellular and molecular mechanisms

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2967544

Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2967544

PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2967544

TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas

28 July 2018

1 reference

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beta1 integrin/FAK/ERK signalling pathway is essential for human fetal islet cell differentiation and survival.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2967544

Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling.

28 October 2018

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Secreted protein acidic, rich in cysteine induces pulp cell migration via alphavbeta3 integrin and extracellular signal-regulated kinase

28 October 2018

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Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells

28 October 2018

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p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis.

28 October 2018

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A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions.

28 October 2018

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Integrin-regulated FAK-Src signaling in normal and cancer cells

28 October 2018

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Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

28 October 2018

1 reference

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Cellular effects and antitumor activity of RET inhibitor RPI-1 on MEN2A-associated medullary thyroid carcinoma

28 October 2018

1 reference

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Inactivation of Ret/Ptc1 oncoprotein and inhibition of papillary thyroid carcinoma cell proliferation by indolinone RPI-1.

28 October 2018

1 reference

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High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2967544

Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2967544

Beta 1-integrin protects hepatoma cells from chemotherapy induced apoptosis via a mitogen-activated protein kinase dependent pathway

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2967544

p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl)

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2967544

Inhibition of transforming activity of the ret/ptc1 oncoprotein by a 2-indolinone derivative.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2967544

28 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20955590

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

SRC as a potential therapeutic target in solid tumor oncology

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20955590

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1476-4598-9-278

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20955590%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

15 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20955590%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

PubMed publication ID

20955590

1 reference