Signal integration by JNK and p38 MAPK pathways in cancer development (Q37560607)

21 August 2017

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title

Signal integration by JNK and p38 MAPK pathways in cancer development (English)

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21 August 2017

Erwin F Wagner

1

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author name string

Angel R Nebreda

series ordinal

2

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PubMed ID

19629069

21 August 2017

language of work or name

English

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publication date

1 August 2009

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21 August 2017

Nature Reviews Cancer

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21 August 2017

9

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21 August 2017

537-549

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21 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrc2694

21 August 2017

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cites work

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Selective interaction of JNK protein kinase isoforms with transcription factors

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Role of mitogen-activated protein kinase kinase kinases in signal integration

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The functional contrariety of JNK

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AP-1: a double-edged sword in tumorigenesis

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The promise of retinoids to fight against cancer.

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2

31 March 2020

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The p38 signal transduction pathway: activation and function

31 March 2020

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p38 MAP-kinases pathway regulation, function and role in human diseases

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Activating p38 MAPK: new tricks for an old kinase.

31 March 2020

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p38 MAP kinase's emerging role as a tumor suppressor

31 March 2020

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p38alpha: a suppressor of cell proliferation and tumorigenesis

31 March 2020

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Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation

31 March 2020

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JNK2: a negative regulator of cellular proliferation

31 March 2020

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JNK2 is a positive regulator of the cJun transcription factor

31 March 2020

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Suppression of p53-dependent senescence by the JNK signal transduction pathway

31 March 2020

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

31 March 2020

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Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis

31 March 2020

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Chemical genetic analysis of the time course of signal transduction by JNK

31 March 2020

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The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

31 March 2020

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A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

31 March 2020

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TNF-alpha induces two distinct caspase-8 activation pathways

31 March 2020

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JNK phosphorylates paxillin and regulates cell migration

31 March 2020

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JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms

31 March 2020

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The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

31 March 2020

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Cell cycle regulation by p38 MAP kinases

31 March 2020

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Non-classical p38 map kinase functions: cell cycle checkpoints and survival

31 March 2020

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Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

31 March 2020

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The pathways to tumor suppression via route p38.

31 March 2020

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p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes

31 March 2020

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p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway

31 March 2020

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p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation

31 March 2020

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p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice.

31 March 2020

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Map kinase signaling pathways and hematologic malignancies

31 March 2020

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pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-

31 March 2020

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p38 MAP kinase signaling is necessary for rat chondrosarcoma cell proliferation.

31 March 2020

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The p38 transduction pathway in prostatic neoplasia

31 March 2020

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Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1.

31 March 2020

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A novel role of p38 alpha MAPK in mitotic progression independent of its kinase activity

31 March 2020

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Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells

31 March 2020

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p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis.

31 March 2020

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Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo

31 March 2020

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Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase.

31 March 2020

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The antiapoptotic effect of heme oxygenase-1 in endothelial cells involves the degradation of p38 alpha MAPK isoform.

31 March 2020

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Models, mechanisms and clinical evidence for cancer dormancy

31 March 2020

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A novel cell type-specific role of p38α in the control of autophagy and cell death in colorectal cancer cells

31 March 2020

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Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.

31 March 2020

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p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis.

31 March 2020

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Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain-induced cardiovascular differentiation.

31 March 2020

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Regulation of skeletal muscle gene expression by p38 MAP kinases.

31 March 2020

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Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation

31 March 2020

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Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation

31 March 2020

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Daphnetin induced differentiation of human renal carcinoma cells and its mediation by p38 mitogen-activated protein kinase.

31 March 2020

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RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells

31 March 2020

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p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

31 March 2020

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Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy

31 March 2020

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p38alpha, but not p38beta, inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling

31 March 2020

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Antagonistic control of cell fates by JNK and p38-MAPK signaling.

31 March 2020

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Feedback control of the protein kinase TAK1 by SAPK2a/p38

31 March 2020

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Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism

31 March 2020

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c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity

31 March 2020

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p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure

31 March 2020

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Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

31 March 2020

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Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2

31 March 2020

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Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling

31 March 2020

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Nuclear factor-kappaB in cancer development and progression

31 March 2020

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Cancer-related inflammation

31 March 2020

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IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

31 March 2020

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Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase

31 March 2020

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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

31 March 2020

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Induction of hepatitis by JNK-mediated expression of TNF-alpha

31 March 2020

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XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

31 March 2020

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Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes

31 March 2020

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Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis

31 March 2020

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UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression

31 March 2020

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COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer

31 March 2020

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EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas

31 March 2020

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p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

31 March 2020

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Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38.

31 March 2020

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The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

31 March 2020

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Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation.

31 March 2020

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Generation and characterization of p38beta (MAPK11) gene-targeted mice.

31 March 2020

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Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation

31 March 2020

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Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling

31 March 2020

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p38 mitogen-activated protein kinase pathway is involved in protein kinase Calpha-regulated invasion in human hepatocellular carcinoma cells

31 March 2020

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p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells

31 March 2020

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MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival

31 March 2020

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Involvement of p38alpha mitogen-activated protein kinase in lung metastasis of tumor cells

31 March 2020

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The p38 MAPK stress pathway as a tumor suppressor or more?

31 March 2020

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The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma.

31 March 2020

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Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7

31 March 2020

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Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.

31 March 2020

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Activation of p38 has opposing effects on the proliferation and migration of endothelial cells

31 March 2020

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CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway

31 March 2020

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Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis

31 March 2020

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MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration

31 March 2020

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Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53

31 March 2020

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Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

31 March 2020

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Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

31 March 2020

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Beyond apoptosis of JNK1 in liver cancer

31 March 2020

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Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

31 March 2020

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JNK signalling modulates intestinal homeostasis and tumourigenesis in mice

31 March 2020

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The role of the transcription factor AP-1 in colitis-associated and β-catenin-dependent intestinal tumorigenesis in mice

31 March 2020

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c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression

31 March 2020

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c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice

31 March 2020

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Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.

31 March 2020

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Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

31 March 2020

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Mechanism of p38 MAP kinase activation in vivo.

31 March 2020

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Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.

31 March 2020

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The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.

31 March 2020

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Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence.

31 March 2020

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Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2.

31 March 2020

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Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells

31 March 2020

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Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis

31 March 2020

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PRAK is essential for ras-induced senescence and tumor suppression

31 March 2020

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Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination

31 March 2020

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Role of mitogen-activated protein kinase kinase 4 in cancer

31 March 2020

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The c-jun kinase/stress-activated pathway: regulation, function and role in human disease

31 March 2020

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Patterns of somatic mutation in human cancer genomes

31 March 2020

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

31 March 2020

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Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer

31 March 2020

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The c-Jun NH2-terminal kinase3 (JNK3) gene: genomic structure, chromosomal assignment, and loss of expression in brain tumors.

31 March 2020

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Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.

31 March 2020

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Activator Protein-1 Transcription Factors Are Associated with Progression and Recurrence of Prostate Cancer

31 March 2020

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Function of JunB in transient amplifying cell senescence and progression of human prostate cancer

31 March 2020

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Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer.

31 March 2020

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Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

31 March 2020

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A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity

31 March 2020

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Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma

31 March 2020

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Involvement of multiple signaling pathways in follicular lymphoma transformation: p38-mitogen-activated protein kinase as a target for therapy

31 March 2020

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Selective p38 activation in human non-small cell lung cancer

31 March 2020

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Prognostic significance of phosphorylated P38 mitogen-activated protein kinase and HER-2 expression in lymph node-positive breast carcinoma

31 March 2020

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High-level expression, activation, and subcellular localization of p38-MAP kinase in thyroid neoplasms

31 March 2020

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Modern analytical technologies for the detection of drug abuse and doping

31 March 2020

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p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

31 March 2020

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Suppression of p38-stress kinase sensitizes quiescent leukemic cells to anti-mitotic drugs by inducing proliferative responses in them

31 March 2020

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p38 MAP kinase: a convergence point in cancer therapy

31 March 2020

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Inhibitors of c-Jun N-terminal kinases: JuNK no more?

31 March 2020

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c-Jun N-terminal kinases as potential therapeutic targets

31 March 2020

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A selective small-molecule inhibitor of c-Jun N-terminal kinase 1

31 March 2020

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A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

31 March 2020

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Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

31 March 2020

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A stress signaling pathway in adipose tissue regulates hepatic insulin resistance

31 March 2020

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Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

31 March 2020

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Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis

31 March 2020

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Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis

31 March 2020

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p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP

31 March 2020

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Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis

31 March 2020

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p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells

31 March 2020

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12 December 2020

Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase

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12 December 2020

Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells

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12 December 2020

Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.

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12 December 2020

Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.

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12 December 2020

Identifiers

DOI

10.1038/NRC2694

1 reference

release_ncclrggyabbpnhvdnnsaupo6ia

21 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ncclrggyabbpnhvdnnsaupo6ia

24 November 2022

mapped directly with Wikidata item

PubMed ID

19629069

1 reference

PubMed ID

19629069