Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells (Q34258961)

1 August 2017

Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells (English)

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1 August 2017

Kevin J Duffy

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Gordon B. Mills

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object named as

Gordon B Mills

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1 August 2017

Julia Billiard

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1 August 2017

Jennifer B Dennison

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1 August 2017

Jacques Briand

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1 August 2017

Roland S Annan

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Deping Chai

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Mariela Colón

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Christopher S Dodson

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Seth A Gilbert

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Joel Greshock

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Junping Jing

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1 August 2017

Hong Lu

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Jeanelle E McSurdy-Freed

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1 August 2017

Lisa A Orband-Miller

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Chad J Quinn

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Jessica L Schneck

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Gilbert F Scott

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1 August 2017

Anthony N Shaw

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Gregory M Waitt

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Richard F Wooster

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1 August 2017

6 September 2013

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Creative Commons Attribution 2.0 Generic

1 August 2017

start time

6 September 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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April 2022 Public Data File from Crossref

exact match

https://scigraph.springernature.com/pub.10.1186/2049-3002-1-19

0 references

cites work

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Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors

6 July 2018

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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

6 July 2018

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An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.

6 July 2018

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LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinoma

6 July 2018

1 reference

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Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways

6 July 2018

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

6 July 2018

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Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma

6 July 2018

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MYC on the path to cancer

6 July 2018

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Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation

6 July 2018

1 reference

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Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase.

6 July 2018

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A Protein Epitope Signature Tag (PrEST) library allows SILAC-based absolute quantification and multiplexed determination of protein copy numbers in cell lines

6 July 2018

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N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

6 July 2018

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High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria

6 July 2018

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LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis

6 July 2018

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Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

6 July 2018

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Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha

6 July 2018

1 reference

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Evidence for an alternative glycolytic pathway in rapidly proliferating cells

6 July 2018

1 reference

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Molecular target class is predictive of in vitro response profile

6 July 2018

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Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

6 July 2018

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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

6 July 2018

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

6 July 2018

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LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

6 July 2018

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

6 July 2018

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Absolute SILAC for accurate quantitation of proteins in complex mixtures down to the attomole level.

6 July 2018

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

6 July 2018

1 reference

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

6 July 2018

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FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis

6 July 2018

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Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis

6 July 2018

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High-density miniaturized thermal shift assays as a general strategy for drug discovery

6 July 2018

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Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4

6 July 2018

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In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate

6 July 2018

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Lactate dehydrogenase-5 (LDH-5) expression in human gastric cancer: association with hypoxia-inducible factor (HIF-1alpha) pathway, angiogenic factors production and poor prognosis

6 July 2018

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Mitochondrial permeability transition induced by the anticancer drug etoposide

21 January 2018

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Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5.

21 January 2018

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Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF/VEGFR2(KDR) pathway and prognosis

28 October 2018

1 reference

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Lactate Dehydrogenase 5 Expression in Operable Colorectal Cancer: Strong Association With Survival and Activated Vascular Endothelial Growth Factor Pathway—A Report of the Tumour Angiogenesis Research Group

21 January 2018

1 reference

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Removal of substrate inhibition in a lactate dehydrogenase from human muscle by a single residue change

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24280423

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Physiological parameters in laboratory animals and humans

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24280423

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/2049-3002-1-19

1 reference

Dimensions Publication ID

1 August 2017

0 references

1 reference

1 August 2017

1 reference