The kidney is the principal organ mediating klotho effects (Q34260105)

1 August 2017

title

The kidney is the principal organ mediating klotho effects (English)

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1 August 2017

6

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1 August 2017

5

Reinhold G Erben

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1 August 2017

3

Orson W Moe

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1 August 2017

Karolina Lindberg

1

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1 August 2017

Risul Amin

2

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1 August 2017

Ming-Chang Hu

4

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1 August 2017

Beate Lanske

7

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1 August 2017

Hannes Olauson

8

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1 August 2017

Tobias E Larsson

9

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1 August 2017

publication date

22 May 2014

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Journal of the American Society of Nephrology

1 August 2017

published in

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1 August 2017

volume

25

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1 August 2017

issue

10

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1 August 2017

page(s)

2169-2175

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Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling

1 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Klotho deficiency causes vascular calcification in chronic kidney disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Augmented Wnt signaling in a mammalian model of accelerated aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Klotho converts canonical FGF receptor into a specific receptor for FGF23

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Suppression of aging in mice by the hormone Klotho

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Homeobox genes and connective tissue patterning

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

The impact of nephrectomy and renal transplantation on serum levels of soluble Klotho protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Prevention of glucocorticoid-induced bone loss in mice by inhibition of RANKL.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178446

Embedding of bone samples in methylmethacrylate: an improved method suitable for bone histomorphometry, histochemistry, and immunohistochemistry

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24854271

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1681/ASN.2013111209

1 reference

1 August 2017

1 reference

1 August 2017

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