Mitochondria as subcellular targets for clinically useful anthracyclines (Q34264441)

1 August 2017

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title

Mitochondria as subcellular targets for clinically useful anthracyclines (English)

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1 August 2017

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Jung K

1

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PubMed ID

11377805

1 August 2017

Reszka R

series ordinal

2

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PubMed ID

11377805

1 August 2017

language of work or name

English

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publication date

1 July 2001

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Advanced Drug Delivery Reviews

1 August 2017

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1 August 2017

49

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1 August 2017

1-2

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1 August 2017

87-105

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A clinicopathologic analysis of adriamycin cardiotoxicity

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Mitochondrial targets of drug toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Synthesis and antitumor properties of new glycosides of daunomycinone and adriamycinone

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Anthracycline binding to synthetic and natural membranes. A study using resonance energy transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

In-vivo and in-vitro mitochondrial membrane damages induced in mice by adriamycin and derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Polymorphic phase behaviour of cardiolipin as detected by 31P NMR and freeze-fracture techniques. Effects of calcium, dibucaine and chlorpromazine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Cardiolipin requirement by cytochrome oxidase and the catalytic role of phospholipid

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Adriamycin inactivates cytochrome c oxidase by exclusion of the enzyme from its cardiolipin essential environment

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

The iron(III)-adriamycin complex inhibits cytochrome c oxidase before its inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Cytofluorescence detection of adriamycin-mitochondria interactions in isolated, perfused rat heart

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Interaction of adriamycin with cardiolipin-containing vesicles. Evidence of an embedded site for the dihydroanthraquinone moiety

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Ca2+ as a second messenger within mitochondria of the heart and other tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Na+-independent release of Ca2+ from rat heart mitochondria. Induction by adriamycin aglycone

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Patterns of interaction between anthraquinone drugs and the calcium-release channel from cardiac sarcoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Disruption of mitochondrial calcium homeostasis following chronic doxorubicin administration.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Selective activation of the sodium-independent, cyclosporin A-sensitive calcium pore of cardiac mitochondria by doxorubicin.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Dose-dependent increase in sensitivity to calcium-induced mitochondrial dysfunction and cardiomyocyte cell injury by doxorubicin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Effect of doxorubicin-enhanced hydrogen peroxide and hydroxyl radical formation on calcium sequestration by cardiac sarcoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

EPR studies of copper(II) and cobalt(II) complexes of adriamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Role of iron in the potentiation of anthracycline cardiotoxicity: identification of heart cell mitochondria as a major site of iron-anthracycline interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Hydroxyl radical production and DNA damage induced by anthracycline-iron complex

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Oxidative destruction of DNA by the adriamycin-iron complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complex

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Diminished superoxide anion generation by reduced 5-iminodaunorubicin relative to daunorubicin and the relationship to cardiotoxicity of the anthracycline antitumor agents

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Deoxyribose breakdown by the adriamycin semiquinone and H2O2: evidence for hydroxyl radical participation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

OH•-generation by adriamycin semiquinone and H2O2; An explanation for the cardiotoxicity of anthracycline antibiotics

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Free radicals induced by adriamycin-sensitive and adriamycin-resistant cells: a spin-trapping study.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

The definition and measurement of antioxidants in biological systems

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Chelated iron-catalyzed OH. formation from paraquat radicals and H2O2: Mechanism of formate oxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Hydroxyl radical production from hydrogen peroxide and enzymatically generated paraquat radicals: Catalytic requirements and oxygen dependence

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Doxorubicin-dependent lipid peroxidation at low partial pressures of O2

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Radical-driven Fenton reactions: studies with paraquat, adriamycin, and anthraquinone 6-sulfonate and citrate, ATP, ADP, and pyrophosphate iron chelates

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Reactions of the semiquinone free radicals of anti-tumour agents with oxygen and iron complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

An electron paramagnetic resonance study of the interactions between the adriamycin semiquinone, hydrogen peroxide, iron-chelators, and radical scavengers

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Possible intermediates in the action of adriamycin--a pulse radiolysis study

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

One-electron reduction of adriamycin and daunomycin: short-term stability of the semiquinones

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Secondary alcohol metabolites mediate iron delocalization in cytosolic fractions of myocardial biopsies exposed to anticancer anthracyclines. Novel linkage between anthracycline metabolism and iron-induced cardiotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Role of quinone-iron(III) interaction in NADPH-dependent enzymatic generation of hydroxyl radicals

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

A free radical scavenger role for daunomycin: inhibition of nonenzymatic oxidation of NADH

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Spin trapping of free radical species produced during the microsomal metabolism of ethanol

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Mitochondrial permeability transition induced by 1-hydroxyethyl radical

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Hydroperoxide metabolism in mammalian organs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

The free radical theory of aging matures

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Oxidative damage and mitochondrial decay in aging

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Mitochondrial diseases in man and mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Role of mitochondria in oxidative stress and ageing

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Mitochondrial decay in aging

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Oxidants, antioxidants, and the degenerative diseases of aging

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

A possible role for membrane lipid peroxidation in anthracycline nephrotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

One-electron-transfer reactions in biochemical systems. V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase)

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

One-electron transfer reactions in biochemical systems. IV. A mixed mechanism in the reaction of milk xanthine oxidase with electron acceptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Mitochondrial NADH dehydrogenase-catalyzed oxygen radical production by adriamycin, and the relative inactivity of 5-iminodaunorubicin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Effects of Adriamycin on heart mitochondrial function in rested and exercised rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Adriamycin stimulated superoxide formation in submitochondrial particles

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Identification of the site of adriamycin-activation in the heart cell.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Effects of 5-iminodaunorubicin on nucleoli of rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Protective effect of endogenous coenzyme Q on both lipid peroxidation and respiratory chain inactivation induced by an adriamycin-iron complex

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Structural requirements for anthracycline-induced cardiotoxicity and antitumor effects

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Inhibition of transplasma membrane electron transport by transferrin-adriamycin conjugates

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Different distribution of daunomycin in plasma membranes from drug-sensitive and drug-resistant P388 leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Role of membrane lipids in the interaction of daunomycin with plasma membranes from tumor cells: implications in drug-resistance phenomena.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Adriamycin and daunomycin semiquinone membrane/buffer partition constants using the spin-broadening technique

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

The interaction of daunomycin with model membranes. Effect of the lipid physical state and the lipid composition

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Further studies on the generation of reactive oxygen species from activated anthracyclines and the relationship to cytotoxic action and cardiotoxic effects

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

The interaction of adriamycin with cardiolipin in model and rat liver mitochondrial membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Evidence of a complex between adriamycin derivatives and cardiolipin: possible role in cardiotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Fluorescent substances and high molecular weight protein aggregates formed in rat heart mitochondria upon doxorubicin-induced lipid peroxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Detection of Phosphatidylcholine Hydroperoxide Produced in the Heart of the Doxorubicin Administered Mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Demonstration of the existence of an organo-specific NADH dehydrogenase in heart mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Oxidation of cytosolic NADH via complex I of heart mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Excessive formation of hydroxyl radicals and aldehydic lipid peroxidation products in cultured skin fibroblasts from patients with complex I deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Cytochrome c: can't live with it--can't live without it.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Caspase-14 is a novel developmentally regulated protease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Mitochondrial DNA sequence variation in human evolution and disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Chemical determination of free radical-induced damage to DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Preferential oxidation of cardiac mitochondrial DNA following acute intoxication with doxorubicin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Cardioselective and cumulative oxidation of mitochondrial DNA following subchronic doxorubicin administration 1Supported in part by NIH Grant HL58016. The manuscript was not subjected to internal Agency review and, thus, the opinions are those of the

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

Hydroxyl radical generation during mitochondrial electron transfer and the formation of 8-hydroxydesoxyguanosine in mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2801%2900128-4

7 January 2021

10.1016/S0169-409X(01)00128-4

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

11377805