Activation of the HIF pathway in cancer (Q34264604)

1 August 2017

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title

Activation of the HIF pathway in cancer (English)

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1 August 2017

Ratcliffe PJ

3

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author name string

Maxwell PH

series ordinal

1

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1 August 2017

Pugh CW

series ordinal

2

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1 August 2017

publication date

1 June 2001

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Current Opinion in Genetics & Development

1 August 2017

published in

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1 August 2017

volume

11

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1 August 2017

issue

3

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1 August 2017

page(s)

293-299

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 August 2017

cites work

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7 January 2021

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

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7 January 2021

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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7 January 2021

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

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7 January 2021

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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7 January 2021

An essential role for p300/CBP in the cellular response to hypoxia

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7 January 2021

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

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Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

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Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells

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Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)

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Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency

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Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin

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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

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7 January 2021

Targeting gene expression to hypoxic tumor cells

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Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

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Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression

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Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

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7 January 2021

Hypoxia, clonal selection, and the role of HIF-1 in tumor progression

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7 January 2021

The von Hippel-Lindau tumor suppressor protein

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7 January 2021

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

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7 January 2021

Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia

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7 January 2021

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

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7 January 2021

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

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7 January 2021

EPAS1 trans-activation during hypoxia requires p42/p44 MAPK

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7 January 2021

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

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7 January 2021

On the Origin of Cancer Cells

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7 January 2021

Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species.

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7 January 2021

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

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7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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7 January 2021

Suppression of tumor growth through disruption of hypoxia-inducible transcription

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7 January 2021

Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes

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7 January 2021

10.1016/S0959-437X(00)00193-3

Identifiers

DOI

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1 August 2017

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