Heparanase enhances local and systemic osteolysis in multiple myeloma by upregulating the expression and secretion of RANKL (Q34267974)

1 August 2017

Heparanase enhances local and systemic osteolysis in multiple myeloma by upregulating the expression and secretion of RANKL (English)

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1 August 2017

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Yang Yang

1

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1 August 2017

Yongsheng Ren

2

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1 August 2017

Vishnu C Ramani

3

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1 August 2017

Li Nan

4

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1 August 2017

Larry J Suva

5

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1 August 2017

Ralph D Sanderson

6

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1 August 2017

language of work or name

English

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publication date

26 October 2010

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1 August 2017

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1 August 2017

70

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21

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8329-8338

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describes a project that uses

1 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2970667/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis.

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Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis

6 July 2018

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Heparanase: busy at the cell surface

6 July 2018

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Heparanase regulates levels of syndecan-1 in the nucleus

6 July 2018

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Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

6 July 2018

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Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma

6 July 2018

1 reference

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Pathophysiological underpinnings of multiple myeloma progression

6 July 2018

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Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand

6 July 2018

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Heparanase is overexpressed in lung cancer and correlates inversely with patient survival

6 July 2018

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Analyzing real-time PCR data by the comparative C(T) method

6 July 2018

1 reference

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Heparanase promotes bone destruction and invasiveness in prostate cancer

6 July 2018

1 reference

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The pathogenesis of the bone disease of multiple myeloma.

6 July 2018

1 reference

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Clinical significance of urine heparanase in bladder cancer progression

6 July 2018

1 reference

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Function of heparanase in prostate tumorigenesis: potential for therapy

6 July 2018

1 reference

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The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy

6 July 2018

1 reference

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Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma

6 July 2018

1 reference

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Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis

6 July 2018

1 reference

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Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases.

6 July 2018

1 reference

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Heparanase expression in human colorectal cancer and its relationship to tumor angiogenesis, hematogenous metastasis, and prognosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Myeloma cells can directly contribute to the pool of RANKL in bone bypassing the classic stromal and osteoblast pathway of osteoclast stimulation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

New Insights in Myeloma-induced Osteolysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Review of 1027 patients with newly diagnosed multiple myeloma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Soluble syndecan-1 promotes growth of myeloma tumors in vivo

6 July 2018

1 reference

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Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression

6 July 2018

1 reference

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Heparanase expression in primary and metastatic pancreatic cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Pathogenesis of myeloma bone disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Incorporation of the bone marker carboxy-terminal telopeptide of type-1 collagen improves prognostic information of the International Staging System in newly diagnosed symptomatic multiple myeloma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Heparanase promotes growth, angiogenesis and survival of primary breast tumors.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Increased RANKL/OPG mRNA ratio in iliac bone biopsies from women with hip fractures.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Expression of receptor activator of NF-kappaB ligand (RANKL) mRNA in human multiple myeloma cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Inverse correlation between heparan sulfate composition and heparanase-1 gene expression in thyroid papillary carcinomas: a potential role in tumor metastasis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Heparanase mRNA expression during fracture repair in mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Expression of receptor activator of nuclear factor kappaB ligand on bone marrow plasma cells correlates with osteolytic bone disease in patients with multiple myeloma.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Syndecan-1 is targeted to the uropods of polarized myeloma cells where it promotes adhesion and sequesters heparin-binding proteins.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2970667

Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis

28 October 2018

1 reference

12 December 2020

Expression of heparanase in hepatocellular carcinoma has prognostic significance: a tissue microarray study

1 reference

12 December 2020

1 reference

12 December 2020

The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma

1 reference

12 December 2020

High heparanase activity in multiple myeloma is associated with elevated microvessel density

1 reference

12 December 2020

Heparanase promotes the spontaneous metastasis of myeloma cells to bone

1 reference

12 December 2020

10.1158/0008-5472.CAN-10-2179

Identifiers

DOI

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1 August 2017

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1 August 2017

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