FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma (Q34269804)

1 August 2017

title

FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma (English)

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1 August 2017

10

John C Byrd

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1 August 2017

5

James T Dalton

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1 August 2017

Qing Liu

1

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1 August 2017

Lapo Alinari

2

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1 August 2017

Ching-Shih Chen

3

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1 August 2017

Fengting Yan

4

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1 August 2017

Rosa Lapalombella

6

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1 August 2017

Xiaoli Zhang

7

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1 August 2017

Rajeswaran Mani

8

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1 August 2017

Teresa Lin

9

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1 August 2017

Robert A Baiocchi

11

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1 August 2017

Natarajan Muthusamy

12

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1 August 2017

language of work or name

English

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publication date

11 May 2010

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1 August 2017

published in

Clinical Cancer Research

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1 August 2017

volume

16

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1 August 2017

issue

12

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1 August 2017

page(s)

3182-3192

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Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model

1 August 2017

cites work

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

6 July 2018

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FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling

6 July 2018

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Expanding therapeutic options in mantle cell lymphoma

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4180653

FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma

6 July 2018

1 reference

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Mantle cell lymphoma: an update on management

6 July 2018

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Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4180653

Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling

6 July 2018

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Biology and therapy of mantle cell lymphoma

6 July 2018

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Molecular basis of mantle cell lymphoma

6 July 2018

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Characterization of 4 mantle cell lymphoma cell lines

6 July 2018

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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

6 July 2018

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Cellular signaling: pivoting around PDK-1.

6 July 2018

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

6 July 2018

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The regulation of reactive oxygen species production during programmed cell death

6 July 2018

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Bax directly induces release of cytochrome c from isolated mitochondria

6 July 2018

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Mitochondrial permeability transition is a central coordinating event of apoptosis

6 July 2018

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Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice

6 July 2018

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Sphingosine-1-phosphate and its analogue FTY720 diminish acute pulmonary injury in rats with acute necrotizing pancreatitis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4180653

The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4180653

FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4180653

PI3-K/AKT/FKHR and MAPK signaling cascades are redundantly stimulated by a variety of cytokines and contribute independently to proliferation and survival of multiple myeloma cells.

28 October 2018

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Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells

28 October 2018

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The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4180653

Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4180653

The World Health Organization classification of hematological malignancies report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997.

28 October 2018

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Specific lentiviral shRNA-mediated knockdown of cyclin D1 in mantle cell lymphoma has minimal effects on cell survival and reveals a regulatory circuit with cyclin D2

28 October 2018

1 reference

12 December 2020

A novel bcl-1/JH breakpoint from a patient affected by mantle cell lymphoma extends the major translocation cluster

1 reference

12 December 2020

A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation

1 reference

12 December 2020

Long-term graft acceptance in allografted rats and dogs by treatment with a novel immunosuppressant, FTY720

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12 December 2020

Structure of Bcl-1 and IgH-CDR3 rearrangements as clonal markers in mantle cell lymphomas

1 reference

12 December 2020

10.1158/1078-0432.CCR-09-2484

Identifiers

DOI

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1 August 2017

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1 August 2017

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