Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer (Q29618030)

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18725988

30 April 2017

1 reference

ORCID Public Data File 2021

author name string

Carracedo A

1

1 reference

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30 April 2017

Ma L

2

1 reference

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30 April 2017

Teruya-Feldstein J

3

1 reference

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30 April 2017

Rojo F

4

1 reference

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30 April 2017

Salmena L

5

1 reference

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30 April 2017

Alimonti A

6

1 reference

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30 April 2017

Egia A

7

1 reference

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30 April 2017

Sasaki AT

8

1 reference

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30 April 2017

Thomas G

9

1 reference

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30 April 2017

Kozma SC

10

1 reference

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30 April 2017

Papa A

11

1 reference

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30 April 2017

Nardella C

12

1 reference

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30 April 2017

Cantley LC

13

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18725988

30 April 2017

Baselga J

14

1 reference

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30 April 2017

Pandolfi PP

15

1 reference

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18725988

30 April 2017

language of work or name

1 reference

30 April 2017

publication date

September 2008

1 reference

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Journal of Clinical Investigation

30 April 2017

published in

1 reference

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volume

118

1 reference

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page(s)

3065-74

1 reference

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30 April 2017

issue

9

1 reference

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describes a project that uses

30 April 2017

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2518073/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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1 reference

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Defining the role of mTOR in cancer

30 April 2017

1 reference

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Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

30 April 2017

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Identification of Protor as a novel Rictor-binding component of mTOR complex-2

30 April 2017

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Current development of mTOR inhibitors as anticancer agents

30 April 2017

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Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

30 April 2017

1 reference

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TOR signaling in growth and metabolism

30 April 2017

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Rapamycin causes regression of astrocytomas in tuberous sclerosis complex

30 April 2017

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

30 April 2017

1 reference

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Exploiting the PI3K/AKT pathway for cancer drug discovery

30 April 2017

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

30 April 2017

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Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

30 April 2017

1 reference

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Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression

30 April 2017

1 reference

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

30 April 2017

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

30 April 2017

1 reference

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Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

30 April 2017

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

30 April 2017

1 reference

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Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent

30 April 2017

1 reference

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

30 April 2017

1 reference

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

30 April 2017

1 reference

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

30 April 2017

1 reference

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Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model

30 April 2017

1 reference

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Antineoplastic effect of rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts.

3 June 2018

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Signal strength dictates phosphoinositide 3-kinase contribution to Ras/extracellular signal-regulated kinase 1 and 2 activation via differential Gab1/Shp2 recruitment: consequences for resistance to epidermal growth factor receptor inhibition

3 June 2018

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A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

3 June 2018

1 reference

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3 June 2018

1 reference

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Functional inhibition of PI3K by the betaGBP molecule suppresses Ras-MAPK signalling to block cell proliferation

3 June 2018

1 reference

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Rapamycin together with herceptin significantly increased anti-tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells

3 June 2018

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PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR

3 June 2018

1 reference

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Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors

3 June 2018

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Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells

3 June 2018

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3 June 2018

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LY294002 and rapamycin co-operate to inhibit T-cell proliferation

3 June 2018

1 reference

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3 June 2018

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Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

3 June 2018

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Dysregulation of the TSC-mTOR pathway in human disease

3 June 2018

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518073

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

3 June 2018

1 reference

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Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.

3 June 2018

1 reference

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Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.

26 November 2018

1 reference

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Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518073

Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518073

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518073

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2518073

Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration

26 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/18725988

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18725988

30 April 2017

100660

100660

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18725988

2 references

30 April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18725988

2 references

30 April 2017