Calpains: potential targets for alternative chemotherapeutic intervention against human pathogenic trypanosomatids (Q34272471)

1 August 2017

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23 March 2019

28 September 2019

2 October 2019

21 December 2019

Calpains: potential targets for alternative chemotherapeutic intervention against human pathogenic trypanosomatids (English)

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1 August 2017

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23 March 2019

28 September 2019

2 October 2019

21 December 2019

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28 September 2019

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2 October 2019

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21 December 2019

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trypanosomatids

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M H Branquinha

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1 August 2017

F A Marinho

2

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1 August 2017

L S Sangenito

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1 August 2017

S S C Oliveira

4

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1 August 2017

K C Goncalves

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1 August 2017

V Ennes-Vidal

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1 August 2017

C M d'Avila-Levy

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1 August 2017

A L S Santos

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1 August 2017

1 January 2013

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Current Medicinal Chemistry

1 August 2017

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1 August 2017

23 March 2019

28 September 2019

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21 December 2019

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1 August 2017

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1 August 2017

3174-3185

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Creative Commons Attribution-NonCommercial 3.0 Unported

1 August 2017

4 references

23 March 2019

28 September 2019

2 October 2019

on focus list of Wikimedia project

21 December 2019

ScienceSource

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MDL28170, a calpain inhibitor, affects Trypanosoma cruzi metacyclogenesis, ultrastructure and attachment to Rhodnius prolixus midgut

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6 July 2018

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Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches

6 July 2018

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6 July 2018

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Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania

6 July 2018

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Particularities of mitochondrial structure in parasitic protists (Apicomplexa and Kinetoplastida).

6 July 2018

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Proteomic analysis of detergent-solubilized membrane proteins from insect-developmental forms of Trypanosoma cruzi.

6 July 2018

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6 July 2018

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6 July 2018

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Proteomic analysis of Trypanosoma cruzi resistance to Benznidazole

6 July 2018

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The calpains: modular designs and functional diversity

6 July 2018

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Calpain 6 is involved in microtubule stabilization and cytoskeletal organization

6 July 2018

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The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function

6 July 2018

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Phenotypical characteristics, biochemical pathways, molecular targets and putative role of nitric oxide-mediated programmed cell death in Leishmania

6 July 2018

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The therapeutic potential of the calpain family: new aspects.

6 July 2018

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Calcium-dependent proteolytic activity of a cysteine protease caldonopain is detected during Leishmania infection

6 July 2018

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The developmental cell biology of Trypanosoma brucei

6 July 2018

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SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania

6 July 2018

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Characterisation of a new Leishmania META gene and genomic analysis of the META cluster

6 July 2018

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Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes

6 July 2018

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Chemotherapy of human African trypanosomiasis: current and future prospects

6 July 2018

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6 July 2018

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Evaluation of differential gene expression in Leishmania major Friedlin procyclics and metacyclics using DNA microarray analysis

6 July 2018

1 reference

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Inhibition of cysteine protease activity by NO-donors.

6 July 2018

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Proteinases of Trypanosoma cruzi: patential targets for the chemotherapy of Changas desease

6 July 2018

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6 July 2018

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Nitric oxide-mediated proteasome-dependent oligonucleosomal DNA fragmentation in Leishmania amazonensis amastigotes

6 July 2018

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Biological roles of proteases in parasitic protozoa

6 July 2018

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Basic cell biology of Trypanosoma cruzi

6 July 2018

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The calpain family and human disease

6 July 2018

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The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease

6 July 2018

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CAP5.5, a life-cycle-regulated, cytoskeleton-associated protein is a member of a novel family of calpain-related proteins in Trypanosoma brucei

6 July 2018

1 reference

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An alternative, nonapoptotic form of programmed cell death

6 July 2018

1 reference

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Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases

6 July 2018

1 reference

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Calpain inhibitors as therapeutic agents in nerve and muscle degeneration

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

The reservosome of Trypanosoma cruzi epimastigotes: an organelle of the endocytic pathway with a role on metacyclogenesis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Structure and physiological function of calpains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

DNA markers define two major phylogenetic lineages of Trypanosoma cruzi.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

The proteases and pathogenicity of parasitic protozoa

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Calpain inhibition: an overview of its therapeutic potential

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Identification and characterization of inhibitory sequences in four repeating domains of the endogenous inhibitor for calcium-dependent protease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Cell-penetrating inhibitors of calpain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Effects of the calpain inhibitor MDL28170 on the clinically relevant forms of Trypanosoma cruzi in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Expression and cellular localisation of calpain-like proteins in Trypanosoma brucei.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Cell morphogenesis of Trypanosoma brucei requires the paralogous, differentially expressed calpain-related proteins CAP5.5 and CAP5.5V.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Arrested growth of Trypanosoma cruzi by the calpain inhibitor MDL28170 and detection of calpain homologues in epimastigote forms.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Cysteine peptidases in Herpetomonas samuelpessoai are modulated by temperature and dimethylsulfoxide-triggered differentiation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Insights into the role of gp63-like proteins in lower trypanosomatids

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

The critical role of calpain versus caspase activation in excitotoxic injury induced by nitric oxide

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Kinetics of parasite cysteine proteinase inactivation by NO-donors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

A novel extracellular calcium-dependent cysteine proteinase from Crithidia deanei.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Calpain inhibitors, a treatment for Alzheimer's disease: position paper

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Phytocalpains: orthologous calcium-dependent cysteine proteinases

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

On the evolution of programmed cell death: apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Leishmania: overexpression and comparative structural analysis of the stage-regulated meta 1 gene.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Calpain localization changes in coordination with actin-related cytoskeletal changes during early embryonic development of Drosophila.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

The evolutionary expansion of the trypanosomatid flagellates

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Potential contribution of proteases to neuronal damage

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4181241

Upregulation of surface proteins in Leishmania donovani isolated from patients of post kala-azar dermal leishmaniasis

28 October 2018

1 reference

12 December 2020

Multiple effects of pepstatin A on Trypanosoma cruzi epimastigote forms

1 reference

12 December 2020

Structure and physiology of calpain, an enigmatic protease

1 reference

12 December 2020

Trypanosoma cruzi: maintenance in culture modify gene and antigenic expression of metacyclic trypomastigotes

1 reference

12 December 2020

Calcium dependent thiol protease caldonopain and its specific endogenous inhibitor in Leishmania donovani

1 reference

12 December 2020

Evolutionary relationships and protein domain architecture in an expanded calpain superfamily in kinetoplastid parasites

1 reference

12 December 2020

Antileishmanial activity of MDL 28170, a potent calpain inhibitor

1 reference

12 December 2020

Induction of differentiation in Herpetomonas samuelpessoai by dimethylsulfoxide

1 reference

12 December 2020

Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity

1 reference

12 December 2020

Trypanosoma cruzi: a stage-specific calpain-like protein is induced after various kinds of stress

1 reference

12 December 2020

10.2174/0929867311320250010

Identifiers

DOI

1 reference

1 August 2017

1 reference

1 August 2017

1 reference