Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain (Q34274025)

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English	Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain	scientific article

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scholarly article

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Europe PubMed Central

1 August 2017

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain (English)

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Europe PubMed Central

1 August 2017

Alzheimer's disease

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based on heuristic

inferred from title

2

object named as

Rashid Deane

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Europe PubMed Central

1 August 2017

author name string

Berislav V Zlokovic

1

1 reference

Europe PubMed Central

1 August 2017

Abhay P Sagare

3

1 reference

Europe PubMed Central

1 August 2017

Robert D Bell

4

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Europe PubMed Central

1 August 2017

Ethan A Winkler

5

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Europe PubMed Central

1 August 2017

language of work or name

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publication date

5 October 2010

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Europe PubMed Central

1 August 2017

number of pages

13

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Journal of Neurochemistry

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Europe PubMed Central

1 August 2017

115

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Europe PubMed Central

1 August 2017

5

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Europe PubMed Central

1 August 2017

1077-1089

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Europe PubMed Central

1 August 2017

Lead-induced accumulation of beta-amyloid in the choroid plexus: role of low density lipoprotein receptor protein-1 and protein kinase C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

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Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance

1 reference

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Vascular risk factor detection and control may prevent Alzheimer's disease

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Intravenous Immunoglobulins as a Treatment for Alzheimerʼs Disease

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The RAGE axis: a fundamental mechanism signaling danger to the vulnerable vasculature

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Alzheimer disease: New light on an old CLU.

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

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Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1

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The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

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Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition

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Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease

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SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

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Gamma-secretase limits the inflammatory response through the processing of LRP1

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The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells

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Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease

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LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies

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Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2.

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Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease.

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LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model

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The blood-brain barrier in health and chronic neurodegenerative disorders

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Clearance of amyloid-beta by circulating lipoprotein receptors

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Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

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Functional duplication of ligand-binding domains within low-density lipoprotein receptor-related protein for interaction with receptor associated protein, alpha2-macroglobulin, factor IXa and factor VIII.

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Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype

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Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit.

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Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

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A specific amyloid-beta protein assembly in the brain impairs memory

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The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.

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P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

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Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

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LRP and Alzheimer's disease

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Neurovascular mechanisms of Alzheimer's neurodegeneration

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Inflammation and the degenerative diseases of aging

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Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier

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Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

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LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions.

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Phosphorylation of LRP1: regulation of transport and signal transduction

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Lipoprotein receptors in the nervous system

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Clearing the brain's amyloid cobwebs

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Association between coding variability in the LRP gene and the risk of late-onset Alzheimer's disease.

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RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease.

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Brain amyloid accumulates in aged rats with kaolin-induced hydrocephalus.

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LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.

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Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Brain insulin impairs amyloid-beta(1-40) clearance from the brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

All Three LDL Receptor Homology Regions of the LDL Receptor-Related Protein Bind Multiple Ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Efflux of human and mouse amyloid β proteins 1–40 and 1–42 from brain: impairment in a mouse model of alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Association at LRP gene locus with sporadic late-onset Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972355

28 October 2018

Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/20854368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permeability and residual plasma volume of human, Dutch variant, and rat amyloid beta-protein 1-40 at the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/20854368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/20854368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic-morphologic association study: association between the low density lipoprotein-receptor related protein (LRP) and cerebral amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20854368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Second and Fourth Cluster of Class A Cysteine-rich Repeats of the Low Density Lipoprotein Receptor-related Protein Share Ligand-binding Properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/20854368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/20854368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon

1 reference

https://pubmed.ncbi.nlm.nih.gov/20854368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/20854368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/20854368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1471-4159.2010.07002.X

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

ResearchGate publication ID

0 references

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