Chemotherapy resistance in metastatic breast cancer: the evolving role of ixabepilone (Q34274930)

1 August 2017

1 reference

24 July 2020

Chemotherapy resistance in metastatic breast cancer: the evolving role of ixabepilone (English)

1 reference

1 August 2017

1 reference

24 July 2020

1 reference

24 July 2020

1 reference

metastatic breast cancer

1 reference

1 reference

Edgardo Rivera

1

1 reference

1 August 2017

Henry Gomez

series ordinal

2

1 reference

1 August 2017

language of work or name

1 reference

22 October 2010

6 references

1 August 2017

13 March 2019

3 April 2019

17 June 2019

11 November 2019

24 July 2020

Breast Cancer Research

6 references

1 August 2017

13 March 2019

3 April 2019

17 June 2019

11 November 2019

24 July 2020

12 Suppl 2

1 reference

1 August 2017

S2

1 reference

Creative Commons Attribution 2.0 Generic

1 August 2017

5 references

13 March 2019

3 April 2019

17 June 2019

11 November 2019

on focus list of Wikimedia project

24 July 2020

copyright status

copyrighted

0 references

ScienceSource

0 references

exact match

https://scigraph.springernature.com/pub.10.1186/bcr2573

0 references

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Optimizing the treatment of metastatic breast cancer

6 July 2018

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Targeting microtubules for cancer chemotherapy

6 July 2018

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6 July 2018

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Molecular mechanisms of drug resistance

6 July 2018

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Resistance to microtubule-targeted cytotoxins in a K562 leukemia cell variant associated with altered tubulin expression and polymerization.

6 July 2018

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Reduced expression of p27 is a novel mechanism of docetaxel resistance in breast cancer cells

6 July 2018

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Do beta-tubulin mutations have a role in resistance to chemotherapy?

6 July 2018

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Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

6 July 2018

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Monotherapy options in the management of metastatic breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

The biology and medicinal chemistry of epothilones

6 July 2018

1 reference

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ATP binding cassette transporters and drug resistance in breast cancer

6 July 2018

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RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response.

6 July 2018

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Mutations in beta-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines.

6 July 2018

1 reference

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6 July 2018

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Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Rational individualization of oxazaphosphorine-based cancer chemo

6 July 2018

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ABC transporters as phenotypic markers and functional regulators of stem cells

6 July 2018

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

6 July 2018

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A family of drug transporters: the multidrug resistance-associated proteins.

6 July 2018

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Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity

6 July 2018

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A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

6 July 2018

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Involvement of the DNA mismatch repair system in antineoplastic drug resistance

6 July 2018

1 reference

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Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Drug resistance to DNA topoisomerase I and II inhibitors in human leukemia, lymphoma, and multiple myeloma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Vinorelbine (navelbine) as a salvage treatment for advanced breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Structure of tubulin at 6.5 A and location of the taxol-binding site.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Multicenter, Phase II study of capecitabine in taxane-pretreated metastatic breast carcinoma patients

6 July 2018

1 reference

Multicenter phase II study of oral capecitabine (Xeloda(")) in patients with metastatic breast cancer relapsing after treatment with a taxane-containing therapy

21 January 2018

1 reference

Oral capecitabine in anthracycline- and taxane-pretreated advanced/metastatic breast cancer

21 January 2018

1 reference

Clinical effect of irinotecan in advanced and metastatic breast cancer patients previously treated with doxorubicin- and docetaxel-containing regimens

21 January 2018

1 reference

Investigation of MRP-1 protein and MDR-1 P-glycoprotein expression in invasive breast cancer: a prognostic study.

21 January 2018

1 reference

Clinical role of multidrug resistance protein 1 expression in chemotherapy resistance in early-stage breast cancer: the Austrian Breast and Colorectal Cancer Study Group

21 January 2018

1 reference

Paclitaxel resistance in cells with reduced beta-tubulin

21 January 2018

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BetaIII-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability

21 January 2018

1 reference

Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions

21 January 2018

1 reference

Resistance to topoisomerase poisons due to loss of DNA mismatch repair

21 January 2018

1 reference

Significance of mismatch repair protein expression in the chemotherapeutic response of sporadic invasive ductal carcinoma of the breast

21 January 2018

1 reference

Worse survival for TP53 (p53)-mutated breast cancer patients receiving adjuvant CMF.

21 January 2018

1 reference

Epothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubules

21 January 2018

1 reference

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography

21 January 2018

1 reference

Phase I/II study of ixabepilone plus capecitabine in anthracycline-pretreated/resistant and taxane-resistant metastatic breast cancer

21 January 2018

1 reference

Failure of higher-dose paclitaxel to improve outcome in patients with metastatic breast cancer: cancer and leukemia group B trial 9342.

21 January 2018

1 reference

Randomized phase III study of docetaxel compared with paclitaxel in metastatic breast cancer

21 January 2018

1 reference

Phase II study of weekly albumin-bound paclitaxel for patients with metastatic breast cancer heavily pretreated with taxanes

21 January 2018

1 reference

Cost effectiveness of ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment

21 January 2018

1 reference

Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer

21 January 2018

1 reference

Biomarkers predictive for clinical efficacy of taxol-based chemotherapy in advanced breast cancer

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Class III beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Caspase 3 in breast cancer.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2972556

Phase II Clinical Trial of Ixabepilone (BMS-247550), an Epothilone B Analog, in Patients With Taxane-Resistant Metastatic Breast Cancer

28 October 2018

1 reference

Phase II clinical trial of the epothilone B analog, ixabepilone, in patients with non small-cell lung cancer whose tumors have failed first-line platinum-based chemotherapy

21 January 2018

1 reference

12 December 2020

Expression of MRP1, LRP and Pgp in breast carcinoma patients treated with preoperative chemotherapy

1 reference

12 December 2020

MDR1 and thymidylate synthase (TS) gene expressions in advanced breast cancer: relationships to drug exposure, p53 mutations, and clinical outcome of the patients

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12 December 2020

Immunohistochemical Detection of P-glycoprotein in Breast Cancer and Its Significance as a Prognostic Factor

1 reference

12 December 2020

Ability to Acquire Drug Resistance Arises Early during the Tumorigenesis Process

1 reference

12 December 2020

Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine

1 reference

12 December 2020

Multicenter, randomized comparative study of two doses of paclitaxel in patients with metastatic breast cancer

1 reference

12 December 2020

Salvage therapies in women who fail to respond to first-line treatment with fluorouracil, epirubicin, and cyclophosphamide for advanced breast cancer

1 reference

12 December 2020

Overexpression of caspase-3s splice variant in locally advanced breast carcinoma is associated with poor response to neoadjuvant chemotherapy

1 reference

12 December 2020

Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties

1 reference

12 December 2020

Modulation of molecular marker expression by induction chemotherapy in locally advanced breast cancer: correlation with the response to therapy and the expression of MDR1 and LRP

1 reference

12 December 2020

1 reference

12 December 2020

Reduced MLH1 expression in breast tumors after primary chemotherapy predicts disease-free survival

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12 December 2020

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1 reference

12 December 2020

Patterns of loss of heterozygosity in breast carcinoma during neoadjuvant chemotherapy

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12 December 2020

Breast cancer--loss of PTEN predicts resistance to treatment

1 reference

12 December 2020

A Phase II trial of epothilone B analogue BMS-247550 (NSC #710428) ixabepilone, in patients with advanced pancreas cancer: a Southwest Oncology Group study

1 reference

12 December 2020

Identifiers

DOI

10.1186/BCR2573

1 reference

Dimensions Publication ID

1 August 2017

0 references

1 reference

1 August 2017

1 reference