Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates (Q34277305)

1 August 2017

Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates (English)

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1 August 2017

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https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

3 April 2024

5

Löwik CW

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1 August 2017

E. R. van Beek

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14623056

3 April 2024

L. H. Cohen

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14623056

3 April 2024

I. M. Leroy

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14623056

3 April 2024

F. H. Ebetino

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14623056

3 April 2024

C. W G M. Löwik

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14623056

3 April 2024

S. E. Papapoulos

6

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3 April 2024

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14623056

3 April 2024

publication date

1 November 2003

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full work available at URL

1 August 2017

https://api.elsevier.com/content/article/PII:S8756328203002771?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

https://api.elsevier.com/content/article/PII:S8756328203002771?httpAccept=text/plain

3 April 2024

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

3 April 2024

1 reference

1 August 2017

33

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1 August 2017

805-811

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1 August 2017

5

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Mechanisms of action of bisphosphonates

1 August 2017

2

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https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Cytotoxicity of dichloromethane diphosphonate and of 1-hydroxyethane-1,1-diphosphonate in the amoebae of the slime mould Dictyostelium discoideum. A 31P NMR study

3 April 2024

4

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.

3 April 2024

5

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates.

3 April 2024

6

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

3 April 2024

7

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

The intracellular target for the antiresorptive aminobisphosphonate drugs in Dictyostelium discoideum is the enzyme farnesyl diphosphate synthase.

3 April 2024

8

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

The pharmacology of bisphosphonates and new insights into their mechanisms of action

3 April 2024

10

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates

3 April 2024

11

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

3 April 2024

12

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy

3 April 2024

13

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Ultrastructural and cytochemical studies on cell death of osteoclasts induced by bisphosphonate treatment.

3 April 2024

14

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

3 April 2024

15

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo.

3 April 2024

16

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue.

3 April 2024

17

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity.

3 April 2024

18

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Dissociation of binding and antiresorptive properties of hydroxybisphosphonates by substitution of the hydroxyl with an amino group.

3 April 2024

19

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs

3 April 2024

20

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages.

3 April 2024

21

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism

3 April 2024

22

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships

3 April 2024

23

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase

3 April 2024

24

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate

3 April 2024

25

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Tiludronate inhibits protein tyrosine phosphatase activity in osteoclasts.

3 April 2024

26

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

3 April 2024

27

1 reference

https://api.crossref.org/works/10.1016/J.BONE.2003.07.007

3 April 2024

Identifiers

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1 August 2017

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