The importance of LAT in the activation, homeostasis, and regulatory function of T cells (Q34285036)

1 August 2017

The importance of LAT in the activation, homeostasis, and regulatory function of T cells (English)

1 reference

1 August 2017

Shudan Shen

1

1 reference

1 August 2017

Mariana I Chuck

2

1 reference

1 August 2017

Minghua Zhu

3

1 reference

1 August 2017

Deirdre M Fuller

4

1 reference

1 August 2017

Chih-Wen Ou Yang

5

1 reference

1 August 2017

Weiguo Zhang

6

1 reference

1 August 2017

language of work or name

English

0 references

publication date

13 September 2010

1 reference

Journal of Biological Chemistry

1 August 2017

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1 August 2017

285

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1 August 2017

46

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1 August 2017

35393-35405

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The role of the LAT-PLC-gamma1 interaction in T regulatory cell function

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

LAT-mediated signaling in CD4+CD25+ regulatory T cell development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

The SLP-76 family of adapter proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Transmembrane adaptor proteins: organizers of immunoreceptor signalling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

An essential role for Scurfin in CD4+CD25+ T regulatory cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Adaptors as central mediators of signal transduction in immune cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Control of regulatory T cell development by the transcription factor Foxp3

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Zap-70-independent Ca(2+) mobilization and Erk activation in Jurkat T cells in response to T-cell antigen receptor ligation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

How alpha beta T cells deal with induced TCR alpha ablation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

RasGRP links T-cell receptor signaling to Ras

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Essential role of LAT in T cell development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Ligand-activated site-specific recombination in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Inducible site-directed recombination in mouse embryonic stem cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) zeta subunit: regulation of TCR-associated protein tyrosine kinase activity by TCR zeta.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975163

LAT regulates gammadelta T cell homeostasis and differentiation

6 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145052

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145052

A LAT mutation that inhibits T cell development yet induces lymphoproliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145052

How much TCR does a T cell need?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145052

TCR signals mediated by Src family kinases are essential for the survival of naive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145052

Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145052

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145052

Long-Term Survival But Impaired Homeostatic Proliferation of Naive T Cells in the Absence of p56lck

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145052

TCR and IL-7 receptor signals can operate independently or synergize to promote lymphopenia-induced expansion of naive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145052

STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat(Y136F) mice into a lymphoproliferative disorder involving Th1 and CD8 effector T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145052

Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145052

Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145052

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.145052

Recent immune status determines the source of antigens that drive homeostatic T cell expansion

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20837489

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phospho-LAT-independent activation of the ras-mitogen-activated protein kinase pathway: a differential recruitment model of TCR partial agonist signaling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20837489

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.145052

1 reference

1 August 2017

1 reference

1 August 2017

1 reference