Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection (Q34974604)

5 August 2017

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection (English)

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5 August 2017

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Connie L Sommers

1

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5 August 2017

Jan Lee

2

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5 August 2017

Kevin L Steiner

3

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5 August 2017

Jordan M Gurson

4

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5 August 2017

Corinne L Depersis

5

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5 August 2017

Dalal El-Khoury

6

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5 August 2017

Claudette L Fuller

7

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5 August 2017

Elizabeth W Shores

8

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5 August 2017

Paul E Love

9

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5 August 2017

Lawrence E Samelson

10

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5 August 2017

language of work or name

English

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publication date

28 March 2005

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Journal of Experimental Medicine

5 August 2017

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5 August 2017

201

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5 August 2017

7

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5 August 2017

1125-1134

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LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways

5 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Known and potential functions for the SLP-76 adapter protein in regulating T-cell activation and development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

The role of Tec family kinases in T cell development and function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

The Ras/MAPK cascade and the control of positive selection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Positive and negative selection of T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Partners in transcription: NFAT and AP-1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Tec family kinases modulate thresholds for thymocyte development and selection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

T cell activation and the cytoskeleton

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

RasGRP links T-cell receptor signaling to Ras

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Signals involved in thymocyte positive and negative selection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Fc epsilonRI gamma can support T cell development and function in mice lacking endogenous TCR zeta-chain.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

CD28-B7 interactions function to co-stimulate clonal deletion of double-positive thymocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Cellular and biochemical requirements for thymocyte negative selection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

A role for calcium influx in setting the threshold for CD4+CD8+ thymocyte negative selection.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Developmental biology of T cells in T cell-receptor transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

Exclusion and inclusion of α and β T cell receptor alleles

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1538971

LAT, the Linker for Activation of T Cells: A Bridge Between T Cell-Specific and General Signaling Pathways

8 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041869

Identification of the minimal tyrosine residues required for linker for activation of T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041869

Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041869

T cells: getting a GRP on Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041869

A LAT mutation that inhibits T cell development yet induces lymphoproliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041869

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041869

Continued maturation of thymic emigrants in the periphery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041869

Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041869

NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041869

An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041869

Measurement of MAP kinase activation by flow cytometry using phospho-specific antibodies to MEK and ERK: potential for pharmacodynamic monitoring of signal transduction inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041869

Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041869

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041869

Recent thymic emigrants are distinct from most medullary thymocytes

21 January 2018

1 reference

12 December 2020

Degree of ERK activation influences both positive and negative thymocyte selection

1 reference

12 December 2020

Involvement of p21ras activation in T cell CD69 expression

1 reference

12 December 2020

A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3 zeta-deficient mice

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20041869

1 reference

release_jzd4v2oppvavdiyo6ar432wtr4

5 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jzd4v2oppvavdiyo6ar432wtr4

24 November 2022

mapped directly with Wikidata item

PMCID

1538971

1 reference

5 August 2017

1 reference