Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer (Q34287982)

1 August 2017

Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer (English)

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1 August 2017

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David Karnak

1

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1 August 2017

Carl G Engelke

2

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1 August 2017

Leslie A Parsels

3

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1 August 2017

Tasneem Kausar

4

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1 August 2017

Dongping Wei

5

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1 August 2017

Jordan R Robertson

6

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1 August 2017

Katherine B Marsh

7

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1 August 2017

Mary A Davis

8

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1 August 2017

Lili Zhao

9

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1 August 2017

Jonathan Maybaum

10

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1 August 2017

Theodore S Lawrence

11

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1 August 2017

Meredith A Morgan

12

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1 August 2017

language of work or name

English

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publication date

12 August 2014

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1 August 2017

Clinical Cancer Research

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1 August 2017

20

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1 August 2017

19

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1 August 2017

5085-5096

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describes a project that uses

1 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4184968/fullTextXML

inferred from PubMed Central ID database lookup

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Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition

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Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma.

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6 July 2018

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RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

6 July 2018

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A phase I/II trial of intensity modulated radiation (IMRT) dose escalation with concurrent fixed-dose rate gemcitabine (FDR-G) in patients with unresectable pancreatic cancer

6 July 2018

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p53 modulates homologous recombination at I-SceI-induced double-strand breaks through cell-cycle regulation

6 July 2018

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Homologous recombination and its regulation

6 July 2018

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Novel insights into maintaining genomic integrity: Wee1 regulating Mus81/Eme1.

6 July 2018

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Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1.

6 July 2018

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Targeting radiation-induced G(2) checkpoint activation with the Wee-1 inhibitor MK-1775 in glioblastoma cell lines

6 July 2018

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Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an Eastern Cooperative Oncology Group trial

6 July 2018

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Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease

6 July 2018

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Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.

6 July 2018

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MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells.

6 July 2018

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Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression

6 July 2018

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Unleashing Chk1 in cancer therapy.

6 July 2018

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MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts

6 July 2018

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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

6 July 2018

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Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers

6 July 2018

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Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair

6 July 2018

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Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

6 July 2018

1 reference

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In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762.

6 July 2018

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PARP inhibition: PARP1 and beyond

6 July 2018

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The role of RPA2 phosphorylation in homologous recombination in response to replication arrest

6 July 2018

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Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90

6 July 2018

1 reference

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PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

6 July 2018

1 reference

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DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.

6 July 2018

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Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

6 July 2018

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Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells

6 July 2018

1 reference

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Detection of histone H2AX phosphorylation on Ser-139 as an indicator of DNA damage (DNA double-strand breaks)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184968

The combination of epidermal growth factor receptor inhibitors with gemcitabine and radiation in pancreatic cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184968

Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184968

The relationship of premature mitosis to cytotoxicity in response to checkpoint abrogation and antimetabolite treatment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184968

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184968

Tumor-suppressive pathways in pancreatic carcinoma.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184968

Dual human epidermal growth factor receptor 2 (HER2) blockade and hormonal therapy for the treatment of primary HER2-positive breast cancer: one more step toward chemotherapy-free therapy.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184968

Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184968

Bayesian hierarchical changepoint methods in modeling the tumor growth profiles in xenograft experiments.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184968

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184968

Ouabain sensitizes tumor cells but not normal cells to radiation

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25117293

12 December 2020

inferred from PubMed ID database lookup

Mean inactivation dose: a useful concept for intercomparison of human cell survival curves

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25117293

12 December 2020

inferred from PubMed ID database lookup

Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25117293

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1158/1078-0432.CCR-14-1038

1 reference

1 August 2017

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1 August 2017

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