Histone γH2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers (Q34134483)

31 July 2017

title

Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers (English)

1 reference

31 July 2017

Histone γH2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers (English)

1 reference

Crossref

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0523

8 July 2024

0 references

1 reference

pharmacological biomarkers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20823146

8 July 2024

9

Yves Pommier

1 reference

31 July 2017

3

Yong-Wei Zhang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20823146

8 July 2024

author name string

Jiuping Jay Ji

4

1 reference

31 July 2017

Christophe E. Redon

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20823146

8 July 2024

Asako J. Nakamura

2

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8 July 2024

William M. Bonner

5

1 reference

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8 July 2024

Robert J. Kinders

6

1 reference

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8 July 2024

Ralph E. Parchment

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20823146

8 July 2024

James H. Doroshow

8

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8 July 2024

language of work or name

English

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publication date

7 September 2010

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full work available at URL

31 July 2017

https://clincancerres.aacrjournals.org/content/clincanres/16/18/4532.full.pdf

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20823146

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20823146/?tool=EBI

8 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20823146

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20823146/pdf/?tool=EBI

8 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20823146

http://clincancerres.aacrjournals.org/cgi/content/abstract/16/18/4532

8 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20823146

https://europepmc.org/articles/PMC2940983

8 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20823146

https://europepmc.org/articles/PMC2940983?pdf=render

8 July 2024

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20823146

https://doi.org/10.1158/1078-0432.ccr-10-0523

8 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20823146

https://aacrjournals.org/clincancerres/article-pdf/16/18/4532/1991765/4532.pdf

8 July 2024

1 reference

Crossref

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0523

8 July 2024

published in

Clinical Cancer Research

1 reference

31 July 2017

volume

16

1 reference

31 July 2017

issue

18

1 reference

31 July 2017

page(s)

4532-4542

1 reference

Perspective on the Pipeline of Drugs Being Developed with Modulation of DNA Damage as a Target

31 July 2017

cites work

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Immunohistochemical detection of poly(ADP-ribose) polymerase inhibition by ABT-888 in patients with refractory solid tumors and lymphomas

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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GammaH2AX in cancer cells: a potential biomarker for cancer diagnostics, prediction and recurrence

5 July 2018

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The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells

5 July 2018

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gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

5 July 2018

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5 July 2018

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5 July 2018

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A buccal cell model comet assay: development and evaluation for human biomonitoring and nutritional studies

5 July 2018

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ATP-dependent chromatin remodeling and DNA double-strand break repair.

5 July 2018

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DNA-protein cross-links and replication-dependent histone H2AX phosphorylation induced by aminoflavone (NSC 686288), a novel anticancer agent active against human breast cancer cells

5 July 2018

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In vivo formation and repair of DNA double-strand breaks after computed tomography examinations

5 July 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

5 July 2018

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

5 July 2018

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

5 July 2018

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

5 July 2018

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Control of sister chromatid recombination by histone H2AX.

5 July 2018

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DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain

5 July 2018

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Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites

5 July 2018

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Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

5 July 2018

1 reference

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Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines

5 July 2018

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DNA double strand break quantification in skin biopsies

5 July 2018

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DNA damage-induced activation of ATM and ATM-dependent signaling pathways

5 July 2018

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Human follicular stem cells: their presence in plucked hair and follicular cell culture

5 July 2018

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H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity

5 July 2018

1 reference

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A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage

5 July 2018

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Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme

5 July 2018

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XRCC1 and DNA strand break repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

Clinical biomarkers in drug discovery and development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

Genomic instability in mice lacking histone H2AX

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

Histone H2A variants H2AX and H2AZ

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

Parp1-XRCC1 and the repair of DNA double strand breaks in mouse round spermatids.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

gamma-H2AX foci as a biomarker for patient X-ray exposure in pediatric cardiac catheterization: are we underestimating radiation risks?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

DNA double-strand breaks after percutaneous transluminal angioplasty

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

An enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

A rapid flow cytometry test based on histone H2AX phosphorylation for the sensitive and specific diagnosis of ataxia telangiectasia.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

Compressing drug development timelines in oncology using phase '0' trials.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

Flow-cytometric assessment of cellular poly(ADP-ribosyl)ation capacity in peripheral blood lymphocytes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

Promoter cleavage: a topoIIbeta and PARP-1 collaboration.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

Phosphorylated histone H2AX in spheroids, tumors, and tissues of mice exposed to etoposide and 3-amino-1,2,4-benzotriazine-1,3-dioxide

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940983

DNA double-strand breaks and their repair in blood lymphocytes of patients undergoing angiographic procedures

28 October 2018

1 reference

12 December 2020

Histone H2AX Is a Mediator of Gastrointestinal Stromal Tumor Cell Apoptosis following Treatment with Imatinib Mesylate

1 reference

12 December 2020

Utility of antiphosphorylated H2AX antibody (gamma-H2AX) in diagnosing metastatic renal cell carcinoma

1 reference

12 December 2020

Two-tier analysis of histone H2AX phosphorylation allows the identification of Ataxia Telangiectasia heterozygotes

1 reference

12 December 2020

gamma-H2AX foci formation in peripheral blood lymphocytes of tumor patients after local radiotherapy to different sites of the body: dependence on the dose-distribution, irradiated site and time from start of treatment

1 reference

12 December 2020

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

13

1 reference

Crossref

https://api.crossref.org/works/10.1158/1078-0432.CCR-10-0523

8 July 2024

Identifiers

1 reference

31 July 2017

1 reference

31 July 2017

1 reference