Hedgehog signalling in cancer formation and maintenance (Q34291589)

1 August 2017

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title

Hedgehog signalling in cancer formation and maintenance (English)

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1 August 2017

Marina Pasca di Magliano

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1

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1 August 2017

Matthias Hebrok

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2

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1 August 2017

language of work or name

English

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publication date

1 December 2003

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1 August 2017

Nature Reviews Cancer

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1 August 2017

3

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12

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1 August 2017

903-911

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https://scigraph.springernature.com/pub.10.1038/nrc1229

1 August 2017

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cites work

Mutations affecting segment number and polarity in Drosophila

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Hedgehog signaling in animal development: paradigms and principles

31 March 2020

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Biochemical evidence that patched is the Hedgehog receptor

31 March 2020

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The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

31 March 2020

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Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog

31 March 2020

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Characterization of two patched receptors for the vertebrate hedgehog protein family

31 March 2020

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Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis.

31 March 2020

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Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

31 March 2020

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Transducing the hedgehog signal

31 March 2020

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Gli and hedgehog in cancer: tumours, embryos and stem cells.

31 March 2020

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Gli regulation by the opposing activities of fused and suppressor of fused

31 March 2020

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Transducing Hedgehog: the story so far

31 March 2020

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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

31 March 2020

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Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants.

31 March 2020

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Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

31 March 2020

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Hedgehog signaling in pancreas development

31 March 2020

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Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

31 March 2020

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Notochord repression of endodermal Sonic hedgehog permits pancreas development

31 March 2020

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Hedgehog signaling regulation of insulin production by pancreatic beta-cells

31 March 2020

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Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells

31 March 2020

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Combined activities of hedgehog signaling inhibitors regulate pancreas development

31 March 2020

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Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E.

31 March 2020

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Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development

31 March 2020

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Patched1 interacts with cyclin B1 to regulate cell cycle progression

31 March 2020

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Sonic hedgehog opposes epithelial cell cycle arrest

31 March 2020

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Basal cell carcinomas in mice overexpressing sonic hedgehog

31 March 2020

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Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog

31 March 2020

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Identification of an amplified, highly expressed gene in a human glioma

31 March 2020

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Gliomagenesis: genetic alterations and mouse models

31 March 2020

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Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

31 March 2020

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Basal cell carcinomas in mice overexpressing Gli2 in skin

31 March 2020

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Mutations in SUFU predispose to medulloblastoma

31 March 2020

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Human homolog of patched, a candidate gene for the basal cell nevus syndrome

31 March 2020

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Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

31 March 2020

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Altered neural cell fates and medulloblastoma in mouse patched mutants

31 March 2020

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Activating Smoothened mutations in sporadic basal-cell carcinoma

31 March 2020

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Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

31 March 2020

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

31 March 2020

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Molecular Pathogenesis of Lung Cancer

31 March 2020

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Pancreatic cancer biology and genetics

31 March 2020

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

31 March 2020

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Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms

31 March 2020

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

31 March 2020

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A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34

31 March 2020

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Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung

31 March 2020

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Medulloblastoma growth inhibition by hedgehog pathway blockade

31 March 2020

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Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors

31 March 2020

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Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha

31 March 2020

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A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

31 March 2020

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Activators and effectors of ras p21 proteins

31 March 2020

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A role of PDGFRalpha in basal cell carcinoma proliferation

31 March 2020

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Notch1 functions as a tumor suppressor in mouse skin

31 March 2020

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Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis

31 March 2020

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Wnt signals are targets and mediators of Gli function.

31 March 2020

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Hair cycle regulation of Hedgehog signal reception

31 March 2020

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31 March 2020

Pancreatic stem cells

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Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions

31 March 2020

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A molecular signature of metastasis in primary solid tumors

31 March 2020

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Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources

31 March 2020

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Teratogen-mediated inhibition of target tissue response to Shh signaling.

31 March 2020

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

31 March 2020

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Small molecule modulation of Smoothened activity

31 March 2020

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Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

31 March 2020

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Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity

31 March 2020

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Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1229

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Dimensions Publication ID

1 August 2017

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