Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo. (Q34305683)

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English	Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo.	scientific article

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5 February 2020

Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo (English)

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Marcelo J P Ferreira

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Joao Henrique G Lago

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Mariana H Massaoka

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Alisson L Matsuo

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Carlos R Figueiredo

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Camyla F Farias

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Natália Girola

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Denise C Arruda

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Jorge A B Scutti

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Paulete Romoff

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Oriana A Favero

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Luiz R Travassos

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6 June 2012

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e38698

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5 February 2020

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6 June 2012

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β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

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1 reference

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1 reference

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21 January 2018

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Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression.

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28 October 2018

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1 reference

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12 December 2020

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p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65

1 reference

https://pubmed.ncbi.nlm.nih.gov/22701695

12 December 2020

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10.1371/JOURNAL.PONE.0038698

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5 February 2020

2012PLoSO...738698M

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5 February 2020

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5 February 2020

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