Immune surveillance in the skin: mechanisms and clinical consequences (Q34308222)

1 August 2017

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title

Immune surveillance in the skin: mechanisms and clinical consequences (English)

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1 August 2017

Thomas S Kupper

1

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PubMed ID

15039758

1 August 2017

Robert C Fuhlbrigge

series ordinal

2

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1 August 2017

1 March 2004

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Nature Reviews Immunology

1 August 2017

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1 August 2017

4

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1 August 2017

3

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1 August 2017

211-222

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Inflammatory skin diseases, T cells, and immune surveillance

1 August 2017

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The prevalence of skin disease in HIV infection and its relationship to the degree of immunosuppression

31 March 2020

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Prevalence and clinical spectrum of skin diseases in kidney transplant recipients

31 March 2020

1 reference

Atopic dermatitis: molecular mechanisms, clinical aspects and new therapeutical approaches.

31 March 2020

1 reference

Immunologic aspects of dermal and oral lichen planus: a review.

31 March 2020

1 reference

The pathogenesis of alopecia areata

31 March 2020

1 reference

Vesiculobullous diseases with prominent immunologic features

31 March 2020

1 reference

The responses of normal and psoriatic skin to single and multiple topical applications of leukotriene B4

31 March 2020

1 reference

Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells

31 March 2020

1 reference

Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis

31 March 2020

1 reference

Cyclosporine in the treatment of dermatologic disease: an update

31 March 2020

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Interleukin-1 and cutaneous inflammation: a crucial link between innate and acquired immunity

31 March 2020

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Interleukin 7 is produced by murine and human keratinocytes

31 March 2020

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The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity

31 March 2020

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Biology and clinical relevance of naturally occurring antimicrobial peptides

31 March 2020

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Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation

31 March 2020

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Barrier disruption stimulates interleukin-1 alpha expression and release from a pre-formed pool in murine epidermis

31 March 2020

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The role of alpha-melanocyte-stimulating hormone in cutaneous biology

31 March 2020

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Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist.

31 March 2020

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Cytokine-mediated communication by keratinocytes and Langerhans cells with dendritic epidermal T cells

31 March 2020

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Identification and initial characterization of four novel members of the interleukin-1 family

31 March 2020

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31 March 2020

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Toll-like receptors: mammalian "taste receptors" for a smorgasbord of microbial invaders

31 March 2020

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Toll-like receptors and innate immunity

31 March 2020

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Control of adaptive immune responses by Toll-like receptors.

31 March 2020

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Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

31 March 2020

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Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

31 March 2020

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Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

31 March 2020

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

31 March 2020

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Saccharomyces cerevisiae- and Candida albicans-derived mannan induced production of tumor necrosis factor alpha by human monocytes in a CD14- and Toll-like receptor 4-dependent manner

31 March 2020

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A Toll-like receptor recognizes bacterial DNA

31 March 2020

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Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity

31 March 2020

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Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells

31 March 2020

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Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

31 March 2020

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Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

31 March 2020

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Innate immunity: the virtues of a nonclonal system of recognition

31 March 2020

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31 March 2020

Nuclear factor-kappa B.

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T-Cell Function and Migration — Two Sides of the Same Coin

31 March 2020

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Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity

31 March 2020

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Toll-Like Receptor-Mediated Activation of Mast Cells: Implications for Allergic Disease?

31 March 2020

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Cutting edge: distinct Toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells.

31 March 2020

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Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor

31 March 2020

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Human and murine dermis contain dendritic cells. Isolation by means of a novel method and phenotypical and functional characterization

31 March 2020

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Dendritic cells and the control of immunity

31 March 2020

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Developmental regulation of MHC class II transport in mouse dendritic cells.

31 March 2020

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In situ expression of the costimulatory molecules CD80 and CD86 on langerhans cells and inflammatory dendritic epidermal cells (IDEC) in atopic dermatitis

31 March 2020

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Immunomorphological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema

31 March 2020

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Cutaneous lymphocyte antigen-positive T lymphocytes preferentially migrate to the skin but not to the joint in psoriatic arthritis

31 March 2020

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The frequency of CLA+ CD8+ T cells in the blood of psoriasis patients correlates closely with the severity of their disease

31 March 2020

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Differential expression of the HECA-452 antigen (cutaneous lymphocyte associated antigen, CLA) in cutaneous and non-cutaneous T-cell lymphomas

31 March 2020

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Skin-homing T cells in human cutaneous allergic inflammation

31 March 2020

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Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen

31 March 2020

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The immunopathogenesis of cutaneous T-cell lymphoma.

31 March 2020

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Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.

31 March 2020

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Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

31 March 2020

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Dendritic cell immunization route determines CD8+ T cell trafficking to inflamed skin: role for tissue microenvironment and dendritic cells in establishment of T cell-homing subsets

31 March 2020

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Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus

31 March 2020

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Expression of mucosal homing receptor alpha4beta7 by circulating CD4+ cells with memory for intestinal rotavirus

31 March 2020

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Functional cutaneous lymphocyte antigen can be induced in essentially all peripheral blood T lymphocytes.

31 March 2020

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Expression of cutaneous lymphocyte-associated antigen on human CD4(+) and CD8(+) Th2 cells.

31 March 2020

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Skin-homing CLA+ T cells and regulatory CD25+ T cells represent major subsets of human peripheral blood memory T cells migrating in response to CCL1/I-309.

31 March 2020

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Targeting CLA/E-selectin interactions prevents CCR4-mediated recruitment of human Th2 memory cells to human skin in vivo

31 March 2020

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Immune surveillance and effector functions of CCR10(+) skin homing T cells

31 March 2020

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CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin

31 March 2020

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CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells

31 March 2020

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CCL27-CCR10 interactions regulate T cell-mediated skin inflammation

31 March 2020

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Cutting edge: C-C chemokine receptor 6 is essential for arrest of a subset of memory T cells on activated dermal microvascular endothelial cells under physiologic flow conditions in vitro

31 March 2020

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31 March 2020

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Increased CCR4 expression in cutaneous T cell lymphoma

31 March 2020

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Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes

31 March 2020

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Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance

31 March 2020

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E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system

31 March 2020

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Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels

31 March 2020

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Effect of in vivo interleukin-1 on adhesion molecule expression in normal human skin

31 March 2020

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Clinical and immunologic variables in skin of patients with atopic eczema and either positive or negative atopy patch test reactions

31 March 2020

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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

31 March 2020

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CCR7 expression and memory T cell diversity in humans

31 March 2020

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T-cell subpopulations in the development of atopic and contact allergy.

31 March 2020

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Human CD25+ regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals

31 March 2020

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Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells

31 March 2020

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Dermal injection of immunocytes induces psoriasis

31 March 2020

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Immunologic targets in psoriasis

31 March 2020

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Novel therapies for psoriasis

31 March 2020

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IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach

31 March 2020

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Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions

31 March 2020

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Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease

31 March 2020

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Investigational therapies for psoriasis

31 March 2020

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Cytokine blocking agents in dermatology.

31 March 2020

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Anti-E-selectin is ineffective in the treatment of psoriasis: a randomized trial.

31 March 2020

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Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation

31 March 2020

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Current management and therapy of atopic dermatitis

31 March 2020

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Epidemiology of atopic dermatitis

31 March 2020

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Smallpox vaccination: Risk considerations for patients with atopic dermatitis

31 March 2020

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Old, new, and emerging therapies for atopic dermatitis

31 March 2020

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The British Association of Dermatologists audit of atopic eczema management in secondary care. Phase 2: audit of service process.

31 March 2020

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Immunological differences between intrinsic and extrinsic types of atopic dermatitis

31 March 2020

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A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis

31 March 2020

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Endogenous antimicrobial peptides and skin infections in atopic dermatitis

31 March 2020

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Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes.

31 March 2020

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Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity

31 March 2020

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Allergic contact dermatitis: the cellular effectors

31 March 2020

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Molecular basis of allergic diseases

31 March 2020

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Human CD4+ T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses

31 March 2020

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Cutaneous graft-versus-host disease

31 March 2020

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Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma.

31 March 2020

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Immunological pathomechanisms in vitiligo.

31 March 2020

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High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo

31 March 2020

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A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma

31 March 2020

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Analysis of T cell receptor variability in tumor-infiltrating lymphocytes from a human regressive melanoma. Evidence for in situ T cell clonal expansion

31 March 2020

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Direct evidence to support the immunosurveillance concept in a human regressive melanoma

31 March 2020

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Model predicting survival in stage I melanoma based on tumor progression

31 March 2020

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Image analysis of stage 1 melanoma (1.00-2.50 mm): lymphocytic infiltrates related to metastasis and survival

31 March 2020

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Tumor immunity and autoimmunity induced by immunization with homologous DNA

31 March 2020

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Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma

31 March 2020

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Developing recombinant and synthetic vaccines for the treatment of melanoma.

31 March 2020

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Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.

31 March 2020

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Dendritic cells: On the move from bench to bedside

31 March 2020

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Clinical cancer vaccine trials

31 March 2020

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31 March 2020

Vaccines and melanoma

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GM-CSF-secreting melanoma vaccines

31 March 2020

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Dendritic cell-based cancer immunotherapy.

31 March 2020

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Homing of intravenously and intralymphatically injected human dendritic cells generated in vitro from CD34+ hematopoietic progenitor cells

31 March 2020

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Dendritic cell gene therapy

31 March 2020

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Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigen

31 March 2020

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Gene therapy to target dendritic cells from blood to lymph nodes

31 March 2020

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Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans

31 March 2020

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Immunologic responses to vaccinia vaccines administered by different parenteral routes

31 March 2020

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Cellular and immunologic mechanisms in atopic dermatitis

31 March 2020

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Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.

31 March 2020

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Perforin hyperreleasability and depletion in cytotoxic T cells from patients with exacerbated atopic dermatitis and asymptomatic rhinoconjunctivitis allergica

31 March 2020

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P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration.

31 March 2020

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Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen

31 March 2020

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Interleukin-18 is elevated in the sera from patients with atopic dermatitis and from atopic dermatitis model mice, NC/Nga

31 March 2020

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The role of keratinocytes in the pathogenesis of atopic dermatitis

31 March 2020

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Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell-derived cytokines

31 March 2020

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Interferon-gamma promotes exaggerated cytokine production in keratinocytes cultured from patients with atopic dermatitis

31 March 2020

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Smallpox vaccination reactions, prophylaxis, and therapy of complications

31 March 2020

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12 December 2020

Pathogenesis of psoriasis

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12 December 2020

The interleukin-1 axis and cutaneous inflammation.

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12 December 2020

Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes.

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12 December 2020

Overexpression of the T-cell receptor beta-chain variable region TCRBV14 in HLA-A2-matched primary human melanomas

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12 December 2020

Participation of T lymphocytes in cutaneous allergic reactions to drugs

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12 December 2020

Spontaneous leukocyte rolling in venules in untraumatized skin of conscious and anesthetized animals

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12 December 2020

Smallpox: clinical and epidemiologic features

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12 December 2020

T lymphocytes expressing HECA-452 epitope are present in cutaneous acute graft-versus-host disease and erythema multiforme, but not in acute graft-versus-host disease in gut organs

1 reference

12 December 2020

Pathogenesis of cutaneous T-cell lymphoma: implications for the use of recombinant cytokines and photopheresis.

1 reference

12 December 2020

A survey of treatments used in patients with metastatic melanoma: analysis of 189 patients referred to the National Cancer Institute

1 reference

12 December 2020

Evidence for in situ amplification of cytotoxic T-lymphocytes with antitumor activity in a human regressive melanoma.

1 reference

12 December 2020

Major histocompatibility antigens and mononuclear inflammatory infiltrate in benign nevomelanocytic proliferations and malignant melanoma

1 reference

12 December 2020

Atopic dermatitis: immunobiology and treatment with immune modulators.

1 reference

12 December 2020

The atopic eczema/dermatitis syndrome. Epidemiology, natural course, and immunology of the IgE-associated ("extrinsic") and the nonallergic ("intrinsic") AEDS.

1 reference

12 December 2020

Keratinocytes in epidermal immune responses

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12 December 2020

A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites

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12 December 2020

Long-lived Th2 clones specific for seasonal and perennial allergens can be detected in blood and skin by their TCR-hypervariable regions

1 reference

12 December 2020

Cutaneous T cell lymphoma: the helping hand of dendritic cells

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12 December 2020

Distinct phenotype of leukemic T cells with various tissue tropisms

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12 December 2020

Epidemiology of atopic dermatitis

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12 December 2020

The histogenesis and biologic behavior of primary human malignant melanomas of the skin

1 reference

12 December 2020

Dendritic cells: unique leukocyte populations which control the primary immune response

1 reference

12 December 2020

Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI1310

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1 August 2017

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PubMed ID

15039758