The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs (Q34309916)

1 August 2017

title

The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs (English)

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1 August 2017

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Steven E Reis

7

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Gordon S. Huggins

8

object named as

Gordon S Huggins

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1 August 2017

Jean-Philippe Fortin

1

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1 August 2017

Lei Ci

2

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1 August 2017

Jonathan Schroeder

3

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1 August 2017

Carmit Goldstein

4

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1 August 2017

Maria Claudia Montefusco

5

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1 August 2017

Inga Peter

6

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1 August 2017

Martin Beinborn

9

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1 August 2017

Alan S Kopin

10

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1 August 2017

language of work or name

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11 August 2010

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1 August 2017

published in

Molecular Pharmacology

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1 August 2017

volume

78

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1 August 2017

issue

5

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1 August 2017

page(s)

837-845

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Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments

1 August 2017

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6 July 2018

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6 July 2018

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The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor

6 July 2018

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Opioid receptor pharmacological chaperones act by binding and stabilizing newly synthesized receptors in the endoplasmic reticulum

6 July 2018

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6 July 2018

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6 July 2018

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Identification of a series of CCK-2 receptor nonpeptide agonists: Sensitivity to stereochemistry and a receptor point mutation

6 July 2018

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A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants

6 July 2018

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Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors

6 July 2018

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beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin

6 July 2018

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6 July 2018

Opioids in chronic pain

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Inverse agonist up-regulates the constitutively active D3.49(164)Q mutant of the rat mu-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-regulation

6 July 2018

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Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding

6 July 2018

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A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling

6 July 2018

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Mutations within the cholecystokinin-B/gastrin receptor ligand 'pocket' interconvert the functions of nonpeptide agonists and antagonists.

6 July 2018

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Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor.

6 July 2018

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mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit

6 July 2018

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Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia

6 July 2018

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Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

6 July 2018

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Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists

6 July 2018

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6 July 2018

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6 July 2018

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A single amino acid substitution in the beta-adrenergic receptor promotes partial agonist activity from antagonists

6 July 2018

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Mu and delta receptors belong to a family of receptors that are coupled to potassium channels

6 July 2018

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6 July 2018

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A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain

28 October 2018

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28 October 2018

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Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene".

28 October 2018

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Ligand function at constitutively active receptor mutants is affected by two distinct yet interacting mechanisms.

28 October 2018

1 reference

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Allelic variation S268P of the human mu-opioid receptor affects both desensitization and G protein coupling.

28 October 2018

1 reference

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mu-Opioid receptor-mediated reduction of neuronal calcium current occurs via a G(o)-type GTP-binding protein

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981363

GPCR NaVa database: natural variants in human G protein-coupled receptors

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20702761

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/MOL.110.064188

1 reference

1 August 2017

1 reference

1 August 2017

1 reference