Neuroimmunophilins: novel neuroprotective and neuroregenerative targets (Q34309932)

1 August 2017

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title

Neuroimmunophilins: novel neuroprotective and neuroregenerative targets (English)

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1 August 2017

Guo X

1

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1 August 2017

Dillman JF 3rd

series ordinal

2

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1 August 2017

Dawson VL

series ordinal

3

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1 August 2017

Dawson TM

series ordinal

4

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1 August 2017

publication date

1 July 2001

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1 August 2017

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1 August 2017

volume

50

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1 August 2017

issue

1

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1 August 2017

page(s)

6-16

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Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders

1 August 2017

cites work

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A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

21 January 2018

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A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

21 January 2018

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Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

21 January 2018

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Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

21 January 2018

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Neural actions of immunophilin ligands.

21 January 2018

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Functional association of cyclophilin A with HIV-1 virions

21 January 2018

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The ninaA gene required for visual transduction in Drosophila encodes a homologue of cyclosporin A-binding protein

21 January 2018

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Drosophila ninaA gene encodes an eye-specific cyclophilin (cyclosporine A binding protein)

21 January 2018

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The cyclophilin homolog ninaA is a tissue-specific integral membrane protein required for the proper synthesis of a subset of Drosophila rhodopsins

21 January 2018

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Prolyl isomerase requirement for the expression of functional homo-oligomeric ligand-gated ion channels

21 January 2018

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Calcium signalling in T cells stimulated by a cyclophilin B-binding protein

21 January 2018

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Point mutations in v-Myb disrupt a cyclophilin-catalyzed negative regulatory mechanism

21 January 2018

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The tetratricopeptide repeat: a structural motif mediating protein-protein interactions

21 January 2018

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The common tetratricopeptide repeat acceptor site for steroid receptor-associated immunophilins and hop is located in the dimerization domain of Hsp90.

21 January 2018

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Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein

21 January 2018

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Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

21 January 2018

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Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux

21 January 2018

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FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain

21 January 2018

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The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors.

21 January 2018

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Serine/threonine kinase receptors and ligands

21 January 2018

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muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo

21 January 2018

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Overexpression of p59-HBI (FKBP59), full length and domains, and characterization of PPlase activity.

21 January 2018

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Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13

21 January 2018

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The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1

21 January 2018

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The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin

21 January 2018

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Biochemical analysis of mouse FKBP60, a novel member of the FKPB family

21 January 2018

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Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor

21 January 2018

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The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors

21 January 2018

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The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase

21 January 2018

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Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65)

21 January 2018

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High brain densities of the immunophilin FKBP colocalized with calcineurin

21 January 2018

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Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12

21 January 2018

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X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

21 January 2018

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Immunosuppression-induced leukoencephalopathy from tacrolimus (FK506)

21 January 2018

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Immunopharmacology of rapamycin

21 January 2018

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

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The human gene encoding FKBP-rapamycin associated protein (FRAP) maps to chromosomal band 1p36.2.

21 January 2018

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Immunophilins and nervous system

21 January 2018

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

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Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling

21 January 2018

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The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin

21 January 2018

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Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A

21 January 2018

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Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA

21 January 2018

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

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Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP.

21 January 2018

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Amphiphysin I is associated with coated endocytic intermediates and undergoes stimulation-dependent dephosphorylation in nerve terminals

21 January 2018

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Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin

21 January 2018

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Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity

21 January 2018

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Potential role of calcineurin for brain ischemia and traumatic injury

21 January 2018

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Calcineurin and mitochondrial function in glutamate-induced neuronal cell death

21 January 2018

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The protective effect of FK506 pretreatment against renal ischemia/reperfusion injury in rats

21 January 2018

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Suppressive effect of FK-506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice

21 January 2018

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Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat.

21 January 2018

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Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia

21 January 2018

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Neuroprotective FK506 does not alter in vivo nitric oxide production during ischemia and early reperfusion in rats

21 January 2018

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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

21 January 2018

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Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia

21 January 2018

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A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration.

21 January 2018

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Generation and evaluation of putative neuroregenerative drugs. Part 2: screening virtual libraries of novel polyketides which possess the binding domain of rapamycin

21 January 2018

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Generation and evaluation of putative neuroregenerative drugs. Part 1: virtual point mutations to the polyketide rapamycin

21 January 2018

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Immunosuppressants, immunophilins, and the nervous system

21 January 2018

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Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models

21 January 2018

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A novel immunophilin ligand: distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease.

21 January 2018

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Immunophilin ligands and GDNF enhance neurite branching or elongation from developing dopamine neurons in culture

21 January 2018

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Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds nerve regeneration

21 January 2018

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The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: neuroprotection and local regeneration.

21 January 2018

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Spontaneous axonal regeneration after optic nerve injury in adult rat.

21 January 2018

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Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo

21 January 2018

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Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANA.1030

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1 August 2017

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