Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling. (Q34310119)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20664002%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

review article

1 reference

title

Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20664002%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20664002%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

Benita Sjögren

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20664002%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

publication date

27 July 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20664002%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

published in

Molecular Pharmacology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20664002%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

78

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20664002%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20664002%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

550-557

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20664002%20AND%20SRC:MED&resulttype=core&format=json

RGS-insensitive Gα subunits: probes of Gα subtype-selective signaling and physiological functions of RGS proteins.

8 February 2020

cites work

1 reference

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Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986

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Non-canonical functions of RGS proteins

6 July 2018

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Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4.

6 July 2018

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Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors

6 July 2018

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Clinical development of novel proteasome inhibitors for cancer treatment

6 July 2018

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Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells

6 July 2018

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The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7

6 July 2018

1 reference

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R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling

6 July 2018

1 reference

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Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles.

6 July 2018

1 reference

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RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node

6 July 2018

1 reference

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Identification of peptides that inhibit regulator of G protein signaling 4 function

6 July 2018

1 reference

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Regulation of Smad-mediated gene transcription by RGS3.

6 July 2018

1 reference

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A role for RGS10 in beta-adrenergic modulation of G-protein-activated K+ (GIRK) channel current in rat atrial myocytes.

6 July 2018

1 reference

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Rgs5 targeting leads to chronic low blood pressure and a lean body habitus

6 July 2018

1 reference

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The RGS2 gene product from a candidate hypertension allele shows decreased plasma membrane association and inhibition of Gq.

6 July 2018

1 reference

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Crystal structure of the multifunctional Gβ5–RGS9 complex

6 July 2018

1 reference

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Motor coordination deficits in mice lacking RGS9

6 July 2018

1 reference

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R4 RGS proteins: regulation of G-protein signaling and beyond

6 July 2018

1 reference

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The mammalian N-end rule pathway: new insights into its components and physiological roles

6 July 2018

1 reference

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Intramolecular interaction between the DEP domain of RGS7 and the Gbeta5 subunit

6 July 2018

1 reference

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N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells

6 July 2018

1 reference

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Palmitoylation: policing protein stability and traffic

6 July 2018

1 reference

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The membrane anchor R7BP controls the proteolytic stability of the striatal specific RGS protein, RGS9-2.

6 July 2018

1 reference

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Genetic and expression aberrations of E3 ubiquitin ligases in human breast cancer

6 July 2018

1 reference

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Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay

6 July 2018

1 reference

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Ubiquitin and ubiquitin-like proteins in cancer pathogenesis

6 July 2018

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DEP-domain-mediated regulation of GPCR signaling responses.

6 July 2018

1 reference

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Impact of the N-terminal amino acid on targeted protein degradation

6 July 2018

1 reference

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R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

RGS17/RGSZ2 and the RZ/A family of regulators of G-protein signaling.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Cellular stress increases RGS2 mRNA and decreases RGS4 mRNA levels in SH-SY5Y cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

RGS4 and RGS5 are in vivo substrates of the N-end rule pathway

6 July 2018

1 reference

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Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signaling

6 July 2018

1 reference

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RGS2 interacts with Gs and adenylyl cyclase in living cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population

6 July 2018

1 reference

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The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

6 July 2018

1 reference

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Generation and characterization of Rgs4 mutant mice

6 July 2018

1 reference

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Regulators of G protein signaling & drugs of abuse.

6 July 2018

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PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.

6 July 2018

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Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action

6 July 2018

1 reference

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The development of proteasome inhibitors as anticancer drugs

6 July 2018

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Essential role for RGS9 in opiate action

6 July 2018

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RGS9 modulates dopamine signaling in the basal ganglia

6 July 2018

1 reference

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Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5

6 July 2018

1 reference

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Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice

6 July 2018

1 reference

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Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability

6 July 2018

1 reference

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Cellular regulation of RGS proteins: modulators and integrators of G protein signaling

6 July 2018

1 reference

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Regulators of G-protein signalling as new central nervous system drug targets.

6 July 2018

1 reference

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An essential role of N-terminal arginylation in cardiovascular development

6 July 2018

1 reference

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Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3

6 July 2018

1 reference

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PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel

6 July 2018

1 reference

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Ca(2+) elevation evoked by membrane depolarization regulates G protein cycle via RGS proteins in the heart

6 July 2018

1 reference

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RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity

6 July 2018

1 reference

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Regulator of G protein signaling proteins: novel multifunctional drug targets

6 July 2018

1 reference

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GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins

6 July 2018

1 reference

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RGS4 is arginylated and degraded by the N-end rule pathway in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Emerging roles for RGS proteins in cell signalling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

6 July 2018

1 reference

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RGS2/G0S8 is a selective inhibitor of Gqalpha function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

A mouse amidase specific for N-terminal asparagine. The gene, the enzyme, and their function in the N-end rule pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

The N-end rule: functions, mysteries, uses

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson's disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

RGS2 is upregulated by and attenuates the hypertrophic effect of alpha1-adrenergic activation in cultured ventricular myocytes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Yeast-based screening for inhibitors of RGS proteins.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Structure-based design, synthesis, and pharmacologic evaluation of peptide RGS4 inhibitors.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Regulation of RGS proteins by chronic morphine in rat locus coeruleus

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Oxidative stress and heat shock stimulate RGS2 expression in 1321N1 astrocytoma cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

RGS4 binds to membranes through an amphipathic alpha -helix.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981398

Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20664002

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulator of G protein signaling 8 (RGS8) requires its NH2 terminus for subcellular localization and acute desensitization of G protein-gated K+ channels

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20664002

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/MOL.110.065219

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20664002%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20664002%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

20664002

1 reference