Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles. (Q37272524)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800065%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

review article

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title

Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18800065%20AND%20SRC:MED&resulttype=core&format=json

protein-protein interaction

14 January 2020

main subject

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2

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14 January 2020

author name string

Levi L Blazer

series ordinal

1

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14 January 2020

language of work or name

English

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publication date

17 September 2008

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14 January 2020

published in

Neuropsychopharmacology

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14 January 2020

volume

34

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14 January 2020

issue

1

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14 January 2020

page(s)

126-141

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https://scigraph.springernature.com/pub.10.1038/npp.2008.151

14 January 2020

exact match

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism

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7 January 2021

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Multi-tasking RGS proteins in the heart: the next therapeutic target?

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Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease

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Diagnosis and treatment of Parkinson disease: molecules to medicine

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Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors

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7 January 2021

Identification of a specific inhibitor of the dishevelled PDZ domain

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7 January 2021

NHERF: targeting and trafficking membrane proteins

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7 January 2021

EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma

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7 January 2021

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7 January 2021

Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications

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7 January 2021

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

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7 January 2021

G protein betagamma subunits as targets for small molecule therapeutic development

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7 January 2021

An association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population

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7 January 2021

Gene copy number variation in schizophrenia

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7 January 2021

Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples

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7 January 2021

Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

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7 January 2021

ASEdb: a database of alanine mutations and their effects on the free energy of binding in protein interactions

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7 January 2021

Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro.

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7 January 2021

Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible function as a hydroxyl radical scavenger.

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7 January 2021

Evaluating chick Galpha-interacting protein selectivity

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Tyrosine kinase inhibitors: from rational design to clinical trials

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Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.151

7 January 2021

Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.151

7 January 2021

Identification of peptides that inhibit regulator of G protein signaling 4 function

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.151

7 January 2021

18 Systematic mutational analyses of protein-protein interfaces

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.151

7 January 2021

Between a rock and a hard place?

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.151

7 January 2021

The retinal specific protein RGS-r competes with the gamma subunit of cGMP phosphodiesterase for the alpha subunit of transducin and facilitates signal termination

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.151

7 January 2021

Support for RGS4 as a susceptibility gene for schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.151

7 January 2021

Significant support for DAO as a schizophrenia susceptibility locus: examination of five genes putatively associated with schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.151

7 January 2021

Structural Basis for the Selectivity of the RGS Protein, GAIP, for G i Family Members: IDENTIFICATION OF A SINGLE AMINO ACID DETERMINANT FOR SELECTIVE INTERACTION OF G i SUBUNITS WITH GAIP

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.151

7 January 2021

https://api.crossref.org/works/10.1038%2FNPP.2008.151

1 reference

7 January 2021

Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.151

7 January 2021

A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protien-mediated kinetic scaffolding.

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.151

7 January 2021

The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2008.151

7 January 2021