Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response (Q34313939)

1 August 2017

Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response (English)

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1 August 2017

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Jacqueline Surls

1

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1 August 2017

Cristina Nazarov-Stoica

2

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1 August 2017

Margaret Kehl

3

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1 August 2017

Cara Olsen

4

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1 August 2017

Sofia Casares

5

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1 August 2017

Teodor-D Brumeanu

6

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1 August 2017

language of work or name

English

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publication date

19 June 2012

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1 August 2017

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1 August 2017

7

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1 August 2017

e38733

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1 August 2017

6

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Creative Commons CC0 License

1 August 2017

start time

19 June 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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cites work

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Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia

6 July 2018

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High dose atorvastatin decreases cellular markers of immune activation without affecting HIV-1 RNA levels: results of a double-blind randomized placebo controlled clinical trial

6 July 2018

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Clinical improvement in psoriasis with treatment of associated hyperlipidemia

6 July 2018

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Revitalizing membrane rafts: new tools and insights

6 July 2018

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High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells

6 July 2018

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New adjuvants for human vaccines

6 July 2018

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Lipid rafts as a membrane-organizing principle

6 July 2018

1 reference

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Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes

6 July 2018

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Lipid Rafts & Co.: an integrated model of membrane organization in T cell activation

6 July 2018

1 reference

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Down-regulation of autoreactive T-cells by HMG CoA reductase inhibitors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Dysregulation of T-cell function in the elderly : scientific basis and clinical implications

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Interleukin-2alpha receptor in membrane lipid rafts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Lipid rafts and their roles in T-cell activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Differential effects of modification of membrane cholesterol and sphingolipids on the conformation, function, and trafficking of the G protein-coupled cholecystokinin receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Cellular cholesterol enrichment impairs T cell activation and chemotaxis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Role of lipid rafts in T cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Lipid rafts in cytokine signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Rafting MHC-II domains in the APC (presynaptic) plasma membrane and the thresholds for T-cell activation and immunological synapse formation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Quantitative differences in lipid raft components between murine CD4+ and CD8+ T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Association of MHC class II-peptide complexes with plasma membrane lipid microdomains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Cholesterol biosynthesis: studies related to the metabolic role of squalene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Sensitive detection of GM1 lipid rafts and TCR partitioning in the T cell membrane

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Landing of immune receptors and signal proteins on lipid rafts: a safe way to be spatio-temporally coordinated?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Fluorescence anisotropy measurements of lipid order in plasma membranes and lipid rafts from RBL-2H3 mast cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Role for lipid rafts in regulating interleukin-2 receptor signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Lipid rafts and signal transduction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Glucocorticoids attenuate T cell receptor signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Different initiation of pre-TCR and gammadeltaTCR signalling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Membrane compartmentation is required for efficient T cell activation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Cellular mechanisms involved in protection against influenza virus infection in transgenic mice expressing a TCR receptor specific for class II hemagglutinin peptide in CD4+ and CD8+ T cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Engineering and characterization of a murine MHC class II-immunoglobulin chimera expressing an immunodominant CD4 T viral epitope

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Lovastatin inhibits T-cell antigen receptor signaling independent of its effects on ras.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Protein prenylation: molecular mechanisms and functional consequences

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

CD28/B7 system of T cell costimulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

The interleukin-2 T-cell system: a new cell growth model.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Characterization of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human adrenal cortex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Inhibition by squalene of the tumor-promoting activity of 12-O-tetradecanoylphorbol-13-acetate in mouse-skin carcinogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Cocarcinogenic and tumor-promoting agents in tobacco carcinogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Lipid microdomain clustering induces a redistribution of antigen recognition and adhesion molecules on human T lymphocytes

6 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038733

Cyclodextrin modulation of T lymphocyte signal transduction with aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038733

Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038733

Atorvastatin restores Lck expression and lipid raft-associated signaling in T cells from patients with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038733

Structure and function of lipid rafts in human activated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038733

Chemopreventive effect of squalene on colon cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038733

Differential effect of CD4+Foxp3+ T-regulatory cells on the B and T helper cell responses to influenza virus vaccination

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038733

CD28 signaling in T regulatory precursors requires p56lck and rafts integrity to stabilize the Foxp3 message

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038733

Differential distribution of both IL-12Rbeta chains in the plasma membrane of human T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038733

Effect of squalene on cyclophosphamide-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038733

Differential localization of IL-2- and -15 receptor chains in membrane rafts of human T cells.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378591

Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation

28 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038733

Differential partitioning and trafficking of GM gangliosides and cholesterol-rich lipid rafts in thymic and splenic CD4 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038733

Down-regulation of diabetogenic CD4+ T cells by a soluble dimeric peptide-MHC class II chimera

21 January 2018

1 reference

12 December 2020

Therapeutic potential of self-antigen-specific CD4+ CD25+ regulatory T cells selected in vitro from a polyclonal repertoire

1 reference

12 December 2020

Dietary squalene increases tissue sterols and fecal bile acids in the rat

1 reference

12 December 2020

Filipin as a flow microfluorometry probe for cellular cholesterol

1 reference

12 December 2020

Promotion of human T lymphocyte activation and proliferation by fatty acids in low density and high density lipoproteins

1 reference

12 December 2020

Provision of cholesterol to lymphocytes by high density and low density lipoproteins. Requirement for low density lipoprotein receptors

1 reference

12 December 2020

Regulation of lymphocyte proliferation by cholesterol: the role of endogenous sterol metabolism and low density lipoprotein receptors

1 reference

12 December 2020

Autocrine regulation of T-lymphocyte proliferation: differential induction of IL-2 and IL-2 receptor

1 reference

12 December 2020

Absorption and fluorescence spectra of polyene antibiotics in the presence of cholesterol

1 reference

12 December 2020

An improved method for detection of low density lipoprotein receptor defects in human T lymphocytes

1 reference

12 December 2020

T lymphocyte costimulation mediated by reorganization of membrane microdomains

1 reference

12 December 2020

The turnover of squalene in relation to the biosynthesis of cholesterol

1 reference

12 December 2020

Release of IL-12 by dendritic cells activated by TLR ligation is dependent on MyD88 signaling, whereas TRIF signaling is indispensable for TLR synergy

1 reference

12 December 2020

Do more complex organisms have a greater proportion of membrane proteins in their genomes?

1 reference

12 December 2020

Immature CD4+CD8+ thymocytes do not polarize lipid rafts in response to TCR-mediated signals

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0038733

Identifiers

DOI

1 reference

release_7wvfrr7cdbfefc3mejudt4st4m

1 August 2017

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1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7wvfrr7cdbfefc3mejudt4st4m

24 November 2022

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PMCID

3378591

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1 August 2017

1 reference