Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate (Q34315046)

1 August 2017

Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate (English)

1 reference

1 August 2017

1 reference

10

Valerie M Weaver

1 reference

1 August 2017

Matthew G Rubashkin

1

1 reference

1 August 2017

Luke Cassereau

2

1 reference

1 August 2017

Russell Bainer

3

1 reference

1 August 2017

Christopher C DuFort

4

1 reference

1 August 2017

Yoshihiro Yui

5

1 reference

1 August 2017

Guanqing Ou

6

1 reference

1 August 2017

Matthew J Paszek

7

1 reference

1 August 2017

Michael W Davidson

8

1 reference

1 August 2017

Yunn-Yi Chen

9

1 reference

1 August 2017

language of work or name

English

0 references

publication date

1 September 2014

1 reference

1 August 2017

1 reference

1 August 2017

74

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1 August 2017

17

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1 August 2017

4597-4611

1 reference

describes a project that uses

1 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4191931/fullTextXML

inferred from PubMed Central ID database lookup

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Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas

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6 July 2018

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Mechanotransduction of mesenchymal melanoma cell invasion into 3D collagen lattices: filopod-mediated extension-relaxation cycles and force anisotropy

6 July 2018

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How vinculin regulates force transmission

6 July 2018

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Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1.

6 July 2018

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Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner

6 July 2018

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Segregation of PIP2 and PIP3 into distinct nanoscale regions within the plasma membrane

6 July 2018

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Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab

6 July 2018

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Phosphorylation primes vinculin for activation

6 July 2018

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Scanning angle interference microscopy reveals cell dynamics at the nanoscale

6 July 2018

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Independent regulation of tumor cell migration by matrix stiffness and confinement.

6 July 2018

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2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen

6 July 2018

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Gene expression profiles of the NCI-60 human tumor cell lines define molecular interaction networks governing cell migration processes

6 July 2018

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Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix

6 July 2018

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Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells

6 July 2018

1 reference

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Biochemical and mechanical extracellular matrix properties dictate mammary epithelial cell motility and assembly

6 July 2018

1 reference

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In situ force mapping of mammary gland transformation

6 July 2018

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Cell-matrix adhesions in 3D

6 July 2018

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Elevated PI3K signaling drives multiple breast cancer subtypes

6 July 2018

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Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties

6 July 2018

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Reducing background fluorescence reveals adhesions in 3D matrices

6 July 2018

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Towards a knowledge-based Human Protein Atlas

6 July 2018

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Nanoscale architecture of integrin-based cell adhesions

6 July 2018

1 reference

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Dynamic interplay between the collagen scaffold and tumor evolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

6 July 2018

1 reference

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Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions

6 July 2018

1 reference

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Vinculin facilitates cell invasion into three-dimensional collagen matrices

6 July 2018

1 reference

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Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin

6 July 2018

1 reference

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Plasticity of cell migration: a multiscale tuning model

6 July 2018

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Matrix crosslinking forces tumor progression by enhancing integrin signaling

6 July 2018

1 reference

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Rethinking screening for breast cancer and prostate cancer

6 July 2018

1 reference

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Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage

6 July 2018

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Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension

6 July 2018

1 reference

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The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells.

6 July 2018

1 reference

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Signal co-operation between integrins and other receptor systems

6 July 2018

1 reference

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Environmental sensing through focal adhesions

6 July 2018

1 reference

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Mechanically activated integrin switch controls alpha5beta1 function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Stretching single talin rod molecules activates vinculin binding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Vinculin controls focal adhesion formation by direct interactions with talin and actin.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Functional atlas of the integrin adhesome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Mechanical properties of collagen fibrils

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Tensional homeostasis and the malignant phenotype

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Spatial distribution and functional significance of activated vinculin in living cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Substrate compliance versus ligand density in cell on gel responses

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Sensing the environment: a historical perspective on integrin signal transduction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Vinculin knockout results in heart and brain defects during embryonic development.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Expression of the adherens junction protein vinculin in human basal and squamous cell tumors: relationship to invasiveness and metastatic potential

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Vinculin promotes cell spreading by mechanically coupling integrins to the cytoskeleton

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

In situ mechanotransduction via vinculin regulates stem cell differentiation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

A distinctive role for focal adhesion proteins in three-dimensional cell motility.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

The stiffness of three-dimensional ionic self-assembling peptide gels affects the extent of capillary-like network formation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

New dimensions in cell migration

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191931

A conformational switch in vinculin drives formation and dynamics of a talin-vinculin complex at focal adhesions

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25183785

12 December 2020

inferred from PubMed ID database lookup

Do cancer cells have distinct adhesions in 3D collagen matrices and in vivo?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25183785

12 December 2020

inferred from PubMed ID database lookup

The nanomechanical signature of breast cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25183785

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1158/0008-5472.CAN-13-3698

1 reference

1 August 2017

1 reference

1 August 2017

1 reference