Microtubule-stabilizing agents: a growing class of important anticancer drugs (Q34318072)

1 August 2017

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title

Microtubule-stabilizing agents: a growing class of important anticancer drugs (English)

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1 August 2017

Altmann KH

1

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1 August 2017

1 August 2001

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Current Opinion in Chemical Biology

1 August 2017

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1 August 2017

5

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1 August 2017

4

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1 August 2017

424-431

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THE DEVELOPMENT AND CLINICAL UTILITY OF THE TAXANE CLASS OF ANTIMICROTUBULE CHEMOTHERAPY AGENTS

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Antimitotic natural products and their interactions with tubulin

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Promotion of microtubule assembly in vitro by taxol

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells--preliminary comparisons to paclitaxel.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Structure-activity profiles of eleutherobin analogs and their cross-resistance in Taxol-resistant cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

A new antimitotic substance, FR182877. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

A new antimitotic substance, FR182877. II. The mechanism of action

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

A new antimitotic substance, FR182877. III. Structure determination

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Microtubules and actin filaments: dynamic targets for cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Molecular effects of paclitaxel: myths and reality (a critical review).

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Preclinical oral antitumor activity of BMS-185660, a paclitaxel derivative.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Synthesis, structure proof, and biological activity of epothilone cyclopropanes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Immunosuppression by discodermolide.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

The role of interleukin-2 in regulating the sensitivity of natural killer cells for Fas-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Acetylated analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Laulimalides. New potent cytotoxic macrolides from a marine sponge and a nudibranch predator

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Fijianolides, polyketide heterocycles from a marine sponge

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

GS-164, a small synthetic compound, stimulates tubulin polymerization by a similar mechanism to that of Taxol

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

New synthetic inhibitors of microtubule depolymerization.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: total synthesis and comparative in vivo evaluations of the 15-aza epothilones

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

Synthesis of 7beta-sulfur analogues of paclitaxel utilizing a novel epimerization of the 7alpha-thiol group

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900225-8

7 January 2021

10.1016/S1367-5931(00)00225-8

Identifiers

DOI

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1 August 2017

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PubMed ID

11470606