Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion (Q34319297)

1 August 2017

title

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion (English)

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1 August 2017

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25

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Johanna Kuusisto

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Alena Stančáková

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object named as

Alena Stančáková

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Francis S Collins

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Christian Fuchsberger

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Christian Fuchsberger

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Karen L Mohlke

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Karen L Mohlke

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Markku Laakso

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Michael Boehnke

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Anne U Jackson

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Heather M Stringham

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Mark J Daly

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Tanya M Teslovich

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Benjamin M Neale

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Roxann Ingersoll

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Peter S Chines

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Martin L Buchkovich

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Jeroen R Huyghe

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Richard M Watanabe

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Henna Cederberg

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Laura J Scott

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Marie P Fogarty

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Xueling Sim

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Lingyao Yang

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Jane M Romm

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Hua Ling

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Ivy McMullen

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Elizabeth W Pugh

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Kimberly F Doheny

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Hyun Min Kang

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language of work or name

English

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publication date

23 December 2012

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1 August 2017

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volume

45

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issue

2

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1 August 2017

page(s)

197-201

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https://scigraph.springernature.com/pub.10.1038/ng.2507

1 August 2017

exact match

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cites work

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

6 July 2018

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Rare-variant association testing for sequencing data with the sequence kernel association test

6 July 2018

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6 July 2018

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In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets

6 July 2018

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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

6 July 2018

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

6 July 2018

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Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

6 July 2018

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6 July 2018

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Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

6 July 2018

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Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men

6 July 2018

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Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function

6 July 2018

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6 July 2018

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Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

6 July 2018

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Common variants at 30 loci contribute to polygenic dyslipidemia

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Functional dissection of Rab GTPases involved in primary cilium formation

6 July 2018

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Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway

6 July 2018

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6 July 2018

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Population structure and eigenanalysis

6 July 2018

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GENCODE: producing a reference annotation for ENCODE

6 July 2018

1 reference

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Insulin vesicle release: walk, kiss, pause ... then run.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727235

The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727235

Genomic control for association studies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727235

Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727235

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727235

Long-range LD can confound genome scans in admixed populations

6 July 2018

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Insulin secretory deficiency and glucose intolerance in Rab3A null mice

21 January 2018

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Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse

21 January 2018

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Oral glucose tolerance test indexes for insulin sensitivity and secretion based on various availabilities of sampling times

21 January 2018

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Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test

21 January 2018

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Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/NG.2507

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1 August 2017

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1 August 2017

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