An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension (Q34319305)

1 August 2017

title

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension (English)

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Fibroblast growth factor 2

1 August 2017

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Apelin

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Fibroblast growth factor receptor 1

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positive regulation of vascular endothelial cell proliferation

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arterial hypertension

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9

Suzy A Comhair

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1 August 2017

11

Serpil C Erzurum

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1 August 2017

Jongmin Kim

1

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1 August 2017

Yujung Kang

2

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1 August 2017

Yoko Kojima

3

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1 August 2017

Janet K Lighthouse

4

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1 August 2017

Xiaoyue Hu

5

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1 August 2017

Micheala A Aldred

6

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1 August 2017

Danielle L McLean

7

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1 August 2017

Hyekyung Park

8

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1 August 2017

Daniel M Greif

10

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1 August 2017

Hyung J Chun

12

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1 August 2017

language of work or name

English

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publication date

23 December 2012

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1 August 2017

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1 August 2017

volume

19

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1 August 2017

issue

1

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1 August 2017

page(s)

74-82

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Human primary lung endothelial cells in culture

1 August 2017

cites work

1 reference

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MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1

6 July 2018

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Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

6 July 2018

1 reference

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Mechanisms of disease: pulmonary arterial hypertension.

6 July 2018

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Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension

6 July 2018

1 reference

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Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension

6 July 2018

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Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis

6 July 2018

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6 July 2018

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MiR-322/424 and -503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A.

6 July 2018

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Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline

6 July 2018

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Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation

6 July 2018

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Endogenous regulation of cardiovascular function by apelin-APJ.

6 July 2018

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Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.

6 July 2018

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Inflammation, growth factors, and pulmonary vascular remodeling

6 July 2018

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Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents

6 July 2018

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Anatomical profiling of G protein-coupled receptor expression

6 July 2018

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The FGF system has a key role in regulating vascular integrity

6 July 2018

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High levels of hyaluronan in idiopathic pulmonary arterial hypertension

6 July 2018

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Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

6 July 2018

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Retardation of retinal vascular development in apelin-deficient mice

6 July 2018

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In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure

6 July 2018

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Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis

6 July 2018

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Cellular and molecular pathobiology of pulmonary arterial hypertension

6 July 2018

1 reference

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Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin

6 July 2018

1 reference

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Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum

6 July 2018

1 reference

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Apelin is a crucial factor for hypoxia-induced retinal angiogenesis

6 July 2018

1 reference

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Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia

28 October 2018

1 reference

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Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension.

28 October 2018

1 reference

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Pathology of pulmonary hypertension

28 October 2018

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Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia.

28 October 2018

1 reference

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Elevated basic fibroblast growth factor levels in patients with pulmonary arterial hypertension

28 October 2018

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12 December 2020

Apelin: A new plasma marker of cardiopulmonary disease

1 reference

12 December 2020

Angiopoietin/Tie2 Pathway Influences Smooth Muscle Hyperplasia in Idiopathic Pulmonary Hypertension

1 reference

12 December 2020

Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension

1 reference

12 December 2020

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3040

7 January 2021

inferred from DOI database lookup

Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3040

7 January 2021

inferred from DOI database lookup

Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3040

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.3040

1 reference

1 August 2017

1 reference

1 August 2017

1 reference