Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT). (Q34325249)

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English	Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).	scientific article

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23 February 2020

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Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) (English)

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23 February 2020

drug metabolism

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based on heuristic

inferred from title

2

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23 February 2020

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Kathleen M Knights

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23 February 2020

John O Miners

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1 October 2013

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23 February 2020

British Journal of Clinical Pharmacology

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23 February 2020

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23 February 2020

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23 February 2020

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Glucuronidation of edaravone by human liver and kidney microsomes: biphasic kinetics and identification of UGT1A9 as the major UDP-glucuronosyltransferase isoform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potentia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

In vitro characterisation of human renal and hepatic frusemide glucuronidation and identification of the UDP-glucuronosyltransferase enzymes involved in this pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Human renal cortical and medullary UDP-glucuronosyltransferases (UGTs): immunohistochemical localization of UGT2B7 and UGT1A enzymes and kinetic characterization of S-naproxen glucuronidation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the C-glucuronidation of phenylbutazone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Cytochrome P450 nomenclature, 2004.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

In vitro metabolism of cyclosporine A by human kidney CYP3A5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

N-glucuronidation of carbamazepine in human tissues is mediated by UGT2B7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Expression of CYP4F12 in gastrointestinal and urogenital epithelia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Almokalant glucuronidation in human liver and kidney microsomes: evidence for the involvement of UGT1A9 and 2B7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human udp-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Urinary metabolites of leukotriene B4 in the human subject

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Relationships between non-occupational cadmium exposure and expression of nine cytochrome P450 forms in human liver and kidney cortex samples

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Glucuronidation of linoleic acid diols by human microsomal and recombinant UDP-glucuronosyltransferases: identification of UGT2B7 as the major isoform involved

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Analysis of the toxic effects of linoleic acid, 12,13-cis-epoxyoctadecenoic acid, and 12,13-dihydroxyoctadecenoic acid in rabbit renal cortical mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Metabolism of anabolic steroids by recombinant human cytochrome P450 enzymes. Gas chromatographic-mass spectrometric determination of metabolites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Drug glucuronidation by human renal UDP-glucuronosyltransferases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Pharmacokinetics of propofol in adult patients undergoing coronary revascularization. The Multicenter Study of Perioperative Ischemia Research Group.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3791982

28 October 2018

Studies on the cytochrome P-450-containing mono-oxygenase system in human kidney cortex microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of estrogen glucosiduronates by human kidney homogenates

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic and inhibitor studies of 4-methylumbelliferone and 1-naphthol glucuronidation in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid metabolism in renal ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucuronidation of morphine in human kidney microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical characterization of the human liver cytochrome P450 arachidonic acid epoxygenase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450-derived renal HETEs: storage and release

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renal and hepatic accumulation of cadmium and lead in the expression of CYP4F2 and CYP2E1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of human UDP-glucuronosyltransferase responsible for the glucuronidation of niflumic acid in human liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of inhibitory fatty acids is responsible for the enhancement of UDP-glucuronosyltransferase 2B7 activity by albumin: implications for in vitro-in vivo extrapolation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 3A5 expression in the kidneys of patients with calcineurin inhibitor nephrotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of niflumic acid as a selective inhibitor of human liver microsomal UDP-glucuronosyltransferase 1A9: application to the reaction phenotyping of acetaminophen glucuronidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linoleic acid diols are novel substrates for human UDP-glucuronosyltransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mycophenolic acid glucuronidation and its inhibition by non-steroidal anti-inflammatory drugs in human liver and kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/BCP.12086

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23362865%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23362865%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23362865%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

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