DNA end joining becomes less efficient and more error-prone during cellular senescence (Q34336407)

1 August 2017

DNA end joining becomes less efficient and more error-prone during cellular senescence (English)

1 reference

1 August 2017

2

David Mittelman

1 reference

1 August 2017

Andrei Seluanov

1

1 reference

1 August 2017

Olivia M Pereira-Smith

series ordinal

3

1 reference

1 August 2017

John H Wilson

series ordinal

4

1 reference

1 August 2017

Vera Gorbunova

series ordinal

5

1 reference

1 August 2017

language of work or name

English

0 references

publication date

28 April 2004

1 reference

1 August 2017

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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1 August 2017

101

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1 August 2017

20

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1 August 2017

7624-7629

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Functional characterization of global genomic DNA repair and its implications for cancer.

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Yeast Rad52 and Rad51 recombination proteins define a second pathway of DNA damage assessment in response to a single double-strand break

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Biochemical evidence for Ku-independent backup pathways of NHEJ

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Comparative levels of DNA breaks and sensitivity to oxidative stress in aged and senescent human fibroblasts: a distinctive pattern for centenarians

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Impact of DNA ligase IV on the fidelity of end joining in human cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Homologous recombination resolution defect in werner syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

The processing of Holliday junctions by BLM and WRN helicases is regulated by p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Large genome rearrangements as a primary cause of aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

The BLM helicase is necessary for normal DNA double-strand break repair.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Sensing and repairing DNA double-strand breaks

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

p53 and recombination intermediates: role of tetramerization at DNA junctions in complex formation and exonucleolytic degradation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Base excision repair is limited by different proteins in male germ cell nuclear extracts prepared from young and old mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

DNA polymerase-beta may be the main player for defective DNA repair in aging rat neurons

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Ku86 is essential in human somatic cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Regulation of cellular senescence by p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Neuronal cell death in nervous system development, disease, and injury (Review).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Tubular cell senescence and expression of TGF-beta1 and p21(WAF1/CIP1) in tubulointerstitial fibrosis of aging rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Deficient DNA end joining activity in extracts from fanconi anemia fibroblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Through a glass, darkly: reflections of mutation from lacI transgenic mice.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Deletion of Ku86 causes early onset of senescence in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Frequency of spontaneous chromosome aberrations in mice: effects of age.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Double-strand break repair in Ku86- and XRCC4-deficient cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end-joining

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

A role for p53 in DNA end rejoining by human cell extracts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Transgenic mouse models for studying mutations in vivo: applications in aging research

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

p53, the cellular gatekeeper for growth and division

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Apoptosis in the pathogenesis and treatment of disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Telomere length and replicative aging in human vascular tissues

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Mechanisms of nonhomologous recombination in mammalian cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Joining of linear plasmid DNA is reduced and error-prone in Bloom's syndrome cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Mutator phenotype of Werner syndrome is characterized by extensive deletions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

DNA damage and repair with age in individual human lymphocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Abnormal processing of transfected plasmid DNA in cells from patients with ataxia telangiectasia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

The clonal evolution of tumor cell populations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419656

Problems in prisons worldwide, with a particular focus on Russia

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0400726101

Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0400726101

Evaluation of the co-mutagenicity of ethanol and delta 9-tetrahydrocannabinol with Trenimon

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0400726101

A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0400726101

Chromosome Aberrations in Liver Cells in Relation to the Somatic Mutation Theory of Aging

21 January 2018

1 reference

12 December 2020

Age-dependent decline in rejoining of X-ray-induced DNA double-strand breaks in normal human lymphocytes

1 reference

12 December 2020

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

12 December 2020

Human p53 binds Holliday junctions strongly and facilitates their cleavage

1 reference

12 December 2020

Effect of age on the formation and repair of UV photoproducts in human skin in situ

1 reference

12 December 2020

Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia

1 reference

12 December 2020

An Age-Induced Switch to a Hyper-Recombinational State

1 reference

12 December 2020

Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis

1 reference

12 December 2020

Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta)

1 reference

12 December 2020

Lack of WRN results in extensive deletion at nonhomologous joining ends

1 reference

12 December 2020

DNA double-strand breaks in mouse kidney cells with age

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0400726101

1 reference

1 August 2017

0 references

1 reference

1 August 2017

1 reference