The transcription factor c-Jun protects against liver damage following activated β-Catenin signaling (Q34336646)

1 August 2017

title

The transcription factor c-Jun protects against liver damage following activated β-Catenin signaling (English)

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1 August 2017

Claudia Trierweiler

1

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1 August 2017

Hubert E Blum

series ordinal

2

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1 August 2017

Peter Hasselblatt

series ordinal

3

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1 August 2017

language of work or name

English

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publication date

6 July 2012

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1 August 2017

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1 August 2017

volume

7

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1 August 2017

issue

7

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1 August 2017

page(s)

e40638

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Creative Commons Attribution 4.0 International

1 August 2017

copyright license

start time

6 July 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391288

The transcription factor c-Jun protects against sustained hepatic endoplasmic reticulum stress thereby promoting hepatocyte survival

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391288

mTOR: from growth signal integration to cancer, diabetes and ageing

6 July 2018

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C-jun inhibits mammary apoptosis in vivo

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391288

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair.

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391288

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

6 July 2018

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Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

6 July 2018

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Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma.

6 July 2018

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B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver

6 July 2018

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Molecular targeted therapies in hepatocellular carcinoma

6 July 2018

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The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391288

Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391288

WNT/beta-catenin signaling in liver health and disease

6 July 2018

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Myc deletion rescues Apc deficiency in the small intestine

6 July 2018

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Wnt/beta-catenin signaling in development and disease

6 July 2018

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c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity

6 July 2018

1 reference

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Apc tumor suppressor gene is the "zonation-keeper" of mouse liver

6 July 2018

1 reference

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Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391288

Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391288

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas

6 July 2018

1 reference

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Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast

6 July 2018

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AP-1: a double-edged sword in tumorigenesis

6 July 2018

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c-Jun regulates eyelid closure and skin tumor development through EGFR signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391288

Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53

6 July 2018

1 reference

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Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3391288

Functions of c-Jun in liver and heart development

6 July 2018

1 reference

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Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas

6 July 2018

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Inducible gene targeting in mice

6 July 2018

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Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate.

6 July 2018

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Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040638

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040638

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040638

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040638

The role of the transcription factor AP-1 in colitis-associated and β-catenin-dependent intestinal tumorigenesis in mice

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040638

The transforming growth factor-α and cyclin D1 genes are direct targets of β-catenin signaling in hepatocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040638

c-Jun is essential for normal mouse development and hepatogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040638

Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22792392

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0040638

1 reference

1 August 2017

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1 August 2017

1 reference