AP-1: a double-edged sword in tumorigenesis (Q30014831)

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21 December 2019

review article

1 reference

title

AP-1: a double-edged sword in tumorigenesis (English)

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22 May 2017

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21 December 2019

1

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21 December 2019

Erwin F. Wagner

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2

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21 December 2019

author name string

Eferl R

series ordinal

1

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14668816

22 May 2017

language of work or name

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22 May 2017

publication date

1 November 2003

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21 December 2019

published in

Nature Reviews Cancer

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22 May 2017

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21 December 2019

volume

3

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22 May 2017

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21 December 2019

issue

11

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22 May 2017

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21 December 2019

page(s)

859-868

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Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity.

21 December 2019

cites work

1 reference

Fortuitous convergences: the beginnings of JUN

31 March 2020

1 reference

AP-1 in mouse development and tumorigenesis

31 March 2020

1 reference

Osteoblasts are target cells for transformation in c-fos transgenic mice

31 March 2020

1 reference

Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

31 March 2020

1 reference

Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53

31 March 2020

1 reference

Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron

31 March 2020

1 reference

Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1

31 March 2020

1 reference

JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers

31 March 2020

1 reference

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

31 March 2020

1 reference

Chronic Myeloid Leukemia with Increased Granulocyte Progenitors in Mice Lacking JunB Expression in the Myeloid Lineage

31 March 2020

1 reference

c-Jun regulates eyelid closure and skin tumor development through EGFR signaling

31 March 2020

1 reference

Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras.

31 March 2020

1 reference

Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription

31 March 2020

1 reference

31 March 2020

The Hallmarks of Cancer

1 reference

Inhibition of AP-1 transcription factor causes blockade of multiple signal transduction pathways and inhibits breast cancer growth

31 March 2020

1 reference

Dual blockade of cyclic AMP response element- (CRE) and AP-1-directed transcription by CRE-transcription factor decoy oligonucleotide. gene-specific inhibition of tumor growth

31 March 2020

1 reference

AP-1 in cell proliferation and survival

31 March 2020

1 reference

Control of cell cycle progression by c-Jun is p53 dependent

31 March 2020

1 reference

c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

31 March 2020

1 reference

Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver

31 March 2020

1 reference

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

31 March 2020

1 reference

Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression.

31 March 2020

1 reference

JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression

31 March 2020

1 reference

JunD protects cells from p53-dependent senescence and apoptosis.

31 March 2020

1 reference

AP-1 as a regulator of cell life and death

31 March 2020

1 reference

c-fos regulates neuronal excitability and survival

31 March 2020

1 reference

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

31 March 2020

1 reference

Functions of c-Jun in liver and heart development

31 March 2020

1 reference

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

31 March 2020

1 reference

DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

31 March 2020

1 reference

Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors

31 March 2020

1 reference

JunD mediates survival signaling by the JNK signal transduction pathway.

31 March 2020

1 reference

Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes

31 March 2020

1 reference

Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells

31 March 2020

1 reference

c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro.

31 March 2020

1 reference

Transcription factors junB and c-jun are selectively up-regulated and functionally implicated in fibrosarcoma development

31 March 2020

1 reference

Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression

31 March 2020

1 reference

JunB is essential for mammalian placentation

31 March 2020

1 reference

Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion

31 March 2020

1 reference

The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions

31 March 2020

1 reference

c-fos is required for malignant progression of skin tumors.

31 March 2020

1 reference

AP-1-mediated invasion requires increased expression of the hyaluronan receptor CD44.

31 March 2020

1 reference

Promoter specificity and biological activity of tethered AP-1 dimers

31 March 2020

1 reference

Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis

31 March 2020

1 reference

Mammalian MAP kinase signalling cascades

31 March 2020

1 reference

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

31 March 2020

1 reference

Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas

31 March 2020

1 reference

Elevated JNK activation contributes to the pathogenesis of human brain tumors

31 March 2020

1 reference

Suppression of Ras-stimulated transformation by the JNK signal transduction pathway

31 March 2020

1 reference

Activation of the JNK signaling pathway: breaking the brake on apoptosis

31 March 2020

1 reference

Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation

31 March 2020

1 reference

The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells

31 March 2020

1 reference

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases

31 March 2020

1 reference

Transformation by ras modifies AP1 composition and activity

31 March 2020

1 reference

Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesis

31 March 2020

1 reference

Cellular transformation and malignancy induced by ras require c-jun

31 March 2020

1 reference

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

31 March 2020

1 reference

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

31 March 2020

1 reference

The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development

31 March 2020

1 reference

c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions

31 March 2020

1 reference

Stepwise transformation of rat embryo fibroblasts: c-Jun, JunB, or JunD can cooperate with Ras for focus formation, but a c-Jun-containing heterodimer is required for immortalization

31 March 2020

1 reference

Cross-talk between glucocorticoid receptor and AP-1.

31 March 2020

1 reference

The promise of retinoids to fight against cancer.

31 March 2020

1 reference

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.

31 March 2020

1 reference

Fra-1 replaces c-Fos-dependent functions in mice

31 March 2020

1 reference

JunB can substitute for Jun in mouse development and cell proliferation

31 March 2020

1 reference

Oncogenic effect of delta deletion in v-Jun does not result from uncoupling Jun from JNK signaling

31 March 2020

1 reference

Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA

31 March 2020

1 reference

Role of DNA 5-methylcytosine transferase in cell transformation by fos

31 March 2020

1 reference

AP-1 mediates stretch-induced expression of HB-EGF in bladder smooth muscle cells.

31 March 2020

1 reference

c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin

31 March 2020

1 reference

The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest

31 March 2020

1 reference

Cooperation between STAT3 and c-jun suppresses Fas transcription.

31 March 2020

1 reference

Krp1, a novel kelch related protein that is involved in pseudopod elongation in transformed cells

31 March 2020

1 reference

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31 March 2020

Identifiers

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22 May 2017

Consolidated OpenCitations Corpus – April 2017

265565

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21 December 2019

1008405783

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24 November 2022

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14668816

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22 May 2017

Consolidated OpenCitations Corpus – April 2017

265565

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668816%20AND%20SRC:MED&resulttype=core&format=json