Understanding the pathogenesis of allergic asthma using mouse models (Q34349777)

1 August 2017

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title

Understanding the pathogenesis of allergic asthma using mouse models (English)

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1 August 2017

0 references

1 reference

Leong KP

1

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1 August 2017

Huston DP

series ordinal

2

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1 August 2017

publication date

1 August 2001

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Annals of Allergy, Asthma & Immunology

1 August 2017

published in

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1 August 2017

volume

87

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1 August 2017

issue

2

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1 August 2017

page(s)

96-109; quiz 110,

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1 August 2017

cites work

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The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration

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TRFK-5 reverses established airway eosinophilia but not established hyperresponsiveness in a murine model of chronic asthma

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An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen

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Shifts in lung lymphocyte profiles correlate with the sequential development of acute allergic and chronic tolerant stages in a murine asthma model

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7 January 2021

Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge

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7 January 2021

Degranulation status of airway tissue eosinophils in mouse models of allergic airway inflammation

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Eosinophils retain their granule major basic protein in a murine model of allergic pulmonary inflammation

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Bronchoconstriction and airway hyperresponsiveness after ovalbumin inhalation in sensitized mice.

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Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness--a murine model

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7 January 2021

Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response

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Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue

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7 January 2021

Dissociation of airway hyperresponsiveness from immunoglobulin E and airway eosinophilia in a murine model of allergic asthma

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7 January 2021

Effect of different sensitizing doses of antigen in a murine model of atopic asthma

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7 January 2021

Genetic variability in pulmonary physiological, cellular, and antibody responses to antigen in mice

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7 January 2021

Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness

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7 January 2021

Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse.

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7 January 2021

Murine allergic respiratory responses to the major house dust mite allergen Der p 1.

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7 January 2021

Mechanics of respiration in unanesthetized guinea pigs

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7 January 2021

Pulmonary responses to bronchoconstrictor agonists in the mouse

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7 January 2021

Mouse models of airway responsiveness: physiological basis of observed outcomes and analysis of selected examples using these outcome indicators

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7 January 2021

Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung

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7 January 2021

Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography

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7 January 2021

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

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7 January 2021

Critical role of CD23 in allergen-induced bronchoconstriction in a murine model of allergic asthma

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7 January 2021

Various immunological phenotypes are associated with increased airway responsiveness

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7 January 2021

Expression of airway hyperreactivity to acetylcholine as a simple autosomal recessive trait in mice

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7 January 2021

A genome-wide screen for asthma-associated quantitative trait loci in a mouse model of allergic asthma

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7 January 2021

Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice

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7 January 2021

T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice

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7 January 2021

Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse

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7 January 2021

Sorting out the cytokines of asthma

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7 January 2021

Interleukin 9: a candidate gene for asthma

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7 January 2021

Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells

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7 January 2021

Induction of adjuvant-independent IgE responses in inbred mice: primary, secondary, and persistent IgE responses to ovalbumin and ovomucoid

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7 January 2021

Airway Responsiveness in Two Inbred Strains of Mouse Disparate in IgE and IL-4 Production

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7 January 2021

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

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7 January 2021

Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors

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7 January 2021

Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice

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7 January 2021

A role for the C3a anaphylatoxin receptor in the effector phase of asthma

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7 January 2021

Attenuation of allergic airway inflammation in IL-4 deficient mice

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7 January 2021

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

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7 January 2021

CD28 interactions with either CD80 or CD86 are sufficient to induce allergic airway inflammation in mice

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7 January 2021

Phenotypic characterization of T lymphocytes emigrating into lung tissue and the airway lumen after antigen inhalation in sensitized mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

T cells are necessary for Th2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Proinflammatory roles of T-cell receptor (TCR)gammadelta and TCRalphabeta lymphocytes in a murine model of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Interleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice

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7 January 2021

Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation

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https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Characterization of the antigen-presenting cell and T cell requirements for induction of pulmonary eosinophilia in a murine model of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

CD80 costimulation is essential for the induction of airway eosinophilia

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Anti-CD86 (B7.2) treatment abolishes allergic airway hyperresponsiveness in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma

1 reference

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7 January 2021

Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins

1 reference

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7 January 2021

Demonstration of the therapeutic potential of non-anaphylactogenic anti-IgE antibodies in murine models of skin reaction, lung function and inflammation

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7 January 2021

Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice

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https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice

1 reference

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7 January 2021

Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice

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7 January 2021

Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes

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7 January 2021

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

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7 January 2021

Development of Eosinophilic Airway Inflammation and Airway Hyperresponsiveness in Mast Cell–deficient Mice

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7 January 2021

Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma

1 reference

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7 January 2021

LFA-1 and ICAM-1 are crucial for the induction of hyperreactivity in the mouse airways

1 reference

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7 January 2021

Reduction of antigen-induced airway hyperreactivity and eosinophilia in ICAM-1-deficient mice

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7 January 2021

The role and contribution of leukotrienes in asthma

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7 January 2021

The importance of leukotrienes in airway inflammation in a mouse model of asthma

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7 January 2021

Allergic lung responses are increased in prostaglandin H synthase-deficient mice.

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7 January 2021

Interleukin-13: central mediator of allergic asthma

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7 January 2021

Requirement for IL-13 independently of IL-4 in experimental asthma

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https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity

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7 January 2021

Interleukin-18 enhances antigen-induced eosinophil recruitment into the mouse airways

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7 January 2021

IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma

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7 January 2021

Essential role of Stat6 in IL-4 signalling

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7 January 2021

Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice

1 reference

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7 January 2021

The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyperresponsiveness is overcome by interleukin-5.

1 reference

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7 January 2021

Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation

1 reference

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7 January 2021

Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

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7 January 2021

Chemokines and asthma: redundancy of function or a coordinated effort?

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7 January 2021

The CC chemokine receptor antagonist met-RANTES inhibits eosinophil effector functions

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Mouse Eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response

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https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness

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7 January 2021

Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice

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7 January 2021

Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia

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7 January 2021

Eosinophils and asthma

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7 January 2021

The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hyperreactivity

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https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity

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7 January 2021

Regulation and modulation of eosinophil effector functions

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7 January 2021

Depletion of eosinophils in mice through the use of antibodies specific for C-C chemokine receptor 3 (CCR3).

1 reference

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7 January 2021

Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma

1 reference

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7 January 2021

Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes

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7 January 2021

Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Immunologic basis of antigen-induced airway hyperresponsiveness

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Dissociation between Airway Inflammation and Airway Hyperresponsiveness in Allergic Asthma

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Inflammation and airway function in asthma: what you see is not necessarily what you get

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Mechanisms of allergic pulmonary eosinophilia in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Therapeutic efficacy of an anti-IL-5 monoclonal antibody delivered into the respiratory tract in a murine model of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL-5 antibody

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Effects of chronic anti-interleukin-5 monoclonal antibody treatment in a murine model of pulmonary inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Inhibitory effect of F-1322 on allergic eosinophil infiltration in airways

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Emergence of oligoclonal T cell populations following therapeutic T cell depletion in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity

1 reference

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7 January 2021

Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation

1 reference

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7 January 2021

IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice

1 reference

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7 January 2021

Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization

1 reference

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7 January 2021

IL-10 deficiency prevents IL-5 overproduction and eosinophilic inflammation in a murine model of asthma-like reaction

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Early identification of interleukin-16 (lymphocyte chemoattractant factor) and macrophage inflammatory protein 1 alpha (MIP1 alpha) in bronchoalveolar lavage fluid of antigen-challenged asthmatics

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Effect of interleukin-16-blocking peptide on parameters of allergic asthma in a murine model

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Eosinophil infiltration precedes development of airway hyperreactivity and mucosal exudation after intranasal administration of interleukin-5 to mice

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

An interleukin 5 mutant distinguishes between two functional responses in human eosinophils.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

The use of cyclosporin in corticosteroid dependent asthma

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Effect of nebulized lidocaine on severe glucocorticoid-dependent asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Nebulized lidocaine in the treatment of severe asthma in children: a pilot study.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Binding of YY1 and Oct1 to a novel element that downregulates expression of IL-5 in human T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Administration of interleukin-12 exerts a therapeutic instead of a long-term preventive effect on mite Der p I allergen-induced animal model of airway inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Ovalbumin (OVA) and Mycobacterium tuberculosis bacilli cooperatively polarize anti-OVA T-helper (Th) cells toward a Th1-dominant phenotype and ameliorate murine tracheal eosinophilia

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model.

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

DNA-Based immunization for asthma

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Immunologic changes associated with allergen immunotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Opposite effects of immunotherapy with ovalbumin and the immunodominant T-cell epitope on airway eosinophilia and hyperresponsiveness in a murine model of allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

T cell immunity to oral allergens

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

Prevention of lung eosinophilic inflammation by oral tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS1081-1206%2810%2962201-6

7 January 2021

10.1016/S1081-1206(10)62201-6

Identifiers

DOI

1 reference

1 August 2017

1 reference