Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle (Q34352145)

1 August 2017

Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle (English)

1 reference

1 August 2017

7

Charles Glabe

1 reference

1 August 2017

Gregor P Lotz

1

1 reference

1 August 2017

Justin Legleiter

2

1 reference

1 August 2017

Rebecca Aron

3

1 reference

1 August 2017

Emily J Mitchell

4

1 reference

1 August 2017

Shao-Yi Huang

5

1 reference

1 August 2017

Cheping Ng

6

1 reference

1 August 2017

Leslie M Thompson

8

1 reference

1 August 2017

Paul J Muchowski

9

1 reference

1 August 2017

language of work or name

English

0 references

publication date

23 September 2010

1 reference

Journal of Biological Chemistry

1 August 2017

1 reference

1 August 2017

285

1 reference

1 August 2017

49

1 reference

1 August 2017

38183-38193

1 reference

Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Secondary Structure of Huntingtin Amino-Terminal Region

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Amyloid oligomer conformation in a group of natively folded proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Structural classification of toxic amyloid oligomers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Adapting proteostasis for disease intervention

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Progressive disruption of cellular protein folding in models of polyglutamine diseases.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Hsp70 chaperones: cellular functions and molecular mechanism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Modulation of neurodegeneration by molecular chaperones

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Pathways of chaperone-mediated protein folding in the cytosol

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Mechanism of substrate recognition by Hsp70 chaperones.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

The energetics of Huntington's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Molecular chaperones in the cytosol: from nascent chain to folded protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

An enzyme that removes clathrin coats: purification of an uncoating ATPase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Hydrodynamics and protein hydration

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992252

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

6 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160218

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160218

Expansion of polyglutamine induces the formation of quasi-aggregate in the early stage of protein fibrillization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160218

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160218

Global changes to the ubiquitin system in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160218

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160218

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160218

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160218

Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160218

In situ AFM studies of astrocyte-secreted apolipoprotein E- and J-containing lipoproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160218

A novel HSP90 chaperone complex regulates intracellular vesicle transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160218

Polyglutamine dances the conformational cha-cha-cha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160218

Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160218

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20864533

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hsp70 and Hsp40 chaperone activities in the cytoplasm and the nucleus of mammalian cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20864533

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.160218

1 reference

1 August 2017

1 reference

1 August 2017

1 reference