Liver regeneration: from myth to mechanism (Q34354926)

1 August 2017

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title

Liver regeneration: from myth to mechanism (English)

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1 August 2017

Rebecca Taub

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1 August 2017

1 October 2004

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Nature Reviews Molecular Cell Biology

1 August 2017

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1 August 2017

5

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1 August 2017

836-847

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1 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrm1489

1 August 2017

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Transcriptional regulatory signals define cytokine-dependent and -independent pathways in liver regeneration

31 March 2020

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31 March 2020

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Control mechanism of the circadian clock for timing of cell division in vivo.

31 March 2020

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31 March 2020

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Cellular origin of regenerating parenchyma in a mouse model of severe hepatic injury

31 March 2020

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Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene

31 March 2020

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The repopulation potential of hepatocyte populations differing in size and prior mitotic expansion

31 March 2020

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Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery

31 March 2020

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Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells

31 March 2020

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Bone marrow as a potential source of hepatic oval cells

31 March 2020

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Purified hematopoietic stem cells can differentiate into hepatocytes in vivo.

31 March 2020

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Transplanted bone marrow regenerates liver by cell fusion

31 March 2020

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The role of hepatocytes and oval cells in liver regeneration and repopulation

31 March 2020

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Regeneration of Rat Liver: Transfer of Humoral Agent by Cross Circulation

31 March 2020

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Induction patterns of 70 genes during nine days after hepatectomy define the temporal course of liver regeneration

31 March 2020

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Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice

31 March 2020

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Independent and overlapping transcriptional activation during liver development and regeneration in mice

31 March 2020

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Gene expression profiling reveals the mechanism and pathophysiology of mouse liver regeneration

31 March 2020

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Plasminogen directs the pleiotropic effects of uPA in liver injury and repair

31 March 2020

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Impaired Ras membrane association and activation in PPARalpha knockout mice after partial hepatectomy

31 March 2020

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Protection against liver damage by cardiotrophin-1: a hepatocyte survival factor up-regulated in the regenerating liver in rats

31 March 2020

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Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury

31 March 2020

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Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy

31 March 2020

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c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration

31 March 2020

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Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury

31 March 2020

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Triiodothyronine enhances the regenerative capacity of the liver following partial hepatectomy

31 March 2020

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Evidence that cyclin D1 mediates both growth and proliferation downstream of TOR in hepatocytes

31 March 2020

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Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation

31 March 2020

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Mitogenic properties of endogenous and pharmacological doses of macrophage inflammatory protein-2 after 70% hepatectomy in the mouse

31 March 2020

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Contribution of cyclooxygenase 2 to liver regeneration after partial hepatectomy.

31 March 2020

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ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice

31 March 2020

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p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver

31 March 2020

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Delayed liver regeneration in peroxisome proliferator-activated receptor-alpha-null mice.

31 March 2020

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Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver

31 March 2020

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Mechanism of retarded liver regeneration in plasminogen activator-deficient mice: Impaired activation of hepatocyte growth factor after Fas-mediated massive hepatic apoptosis

31 March 2020

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Stem cell factor restores hepatocyte proliferation in IL-6 knockout mice following 70% hepatectomy

31 March 2020

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The proinflammatory mediators C3a and C5a are essential for liver regeneration

31 March 2020

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The extent of synchronous initiation and termination of DNA synthesis in regenerating mouse liver is dependent on connexin32 expressing gap junctions

31 March 2020

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A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration.

31 March 2020

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Loss of p27(Kip1) accelerates DNA replication after partial hepatectomy in mice.

31 March 2020

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Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity

31 March 2020

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Angiogenesis-independent endothelial protection of liver: role of VEGFR-1.

31 March 2020

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The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration

31 March 2020

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Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

31 March 2020

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Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor

31 March 2020

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CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy

31 March 2020

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Liver gene disruptions: winners by KO?

31 March 2020

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Impaired liver regeneration in inducible nitric oxide synthasedeficient mice

31 March 2020

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Hepatocyte growth factor gene therapy of liver cirrhosis in rats

31 March 2020

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Preventive and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis

31 March 2020

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Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

31 March 2020

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Normal liver regeneration in p50/nuclear factor kappaB1 knockout mice

31 March 2020

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STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration

31 March 2020

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Transcription factor CREM coordinates the timing of hepatocyte proliferation in the regenerating liver.

31 March 2020

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31 March 2020

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

31 March 2020

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Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy

31 March 2020

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Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration

31 March 2020

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Interleukin 6 is important for survival after partial hepatectomy in mice

31 March 2020

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The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes

31 March 2020

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Effect of TNF gene depletion on liver regeneration after partial hepatectomy in mice

31 March 2020

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Interleukin-6 from intrahepatic cells of bone marrow origin is required for normal murine liver regeneration.

31 March 2020

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Depressed liver regeneration after partial hepatectomy of germ-free, athymic and lipopolysaccharide-resistant mice

31 March 2020

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Evolution of the lectin-complement pathway and its role in innate immunity

31 March 2020

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Global changes in interleukin-6–dependent gene expression patterns in mouse livers after partial hepatectomy

31 March 2020

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Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury.

31 March 2020

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Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver.

31 March 2020

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Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration

31 March 2020

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Massive liver growth in mice induced by systemic interleukin 6 administration.

31 March 2020

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Resolving the role of IL-6 in liver regeneration

31 March 2020

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Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair

31 March 2020

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The processing and utilization of hepatocyte growth factor/scatter factor following partial hepatectomy in the rat

31 March 2020

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Anti-hepatocyte growth factor antibody inhibits hepatocyte proliferation during liver regeneration

31 March 2020

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Hepatocyte growth factor exerts a proliferative effect on oval cells through the PI3K/AKT signaling pathway.

31 March 2020

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Integral role of the EGF receptor in HGF-mediated hepatocyte proliferation

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The mitogenic activity of hepatocyte growth factor on rat hepatocytes is dependent upon endogenous transforming growth factor-alpha

31 March 2020

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Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury

31 March 2020

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Rapid induction of mRNAs for liver regeneration factor and insulin-like growth factor binding protein-1 in primary cultures of rat hepatocytes by hepatocyte growth factor and epidermal growth factor

31 March 2020

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Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice

31 March 2020

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Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent

31 March 2020

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Activation of interleukin-6/STAT3 and liver regeneration following transplantation

31 March 2020

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Ischemia impairs liver regeneration after major tissue loss in rodents: protective effects of interleukin-6

31 March 2020

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The development and compensation of biliary cirrhosis in interleukin-6-deficient mice

31 March 2020

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T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6.

31 March 2020

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Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

31 March 2020

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Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor

31 March 2020

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NFkappaB prevents apoptosis and liver dysfunction during liver regeneration

31 March 2020

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IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

31 March 2020

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Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride

31 March 2020

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Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL.

31 March 2020

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Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms

31 March 2020

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Hepatoprotection via the IL-6/Stat3 pathway

31 March 2020

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Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice

31 March 2020

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Hepatocyte growth factor and c-Met inhibition by hepatic cell hypoxia: a potential mechanism for liver regeneration failure in experimental cirrhosis

31 March 2020

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Hepatocyte growth factor gene therapy accelerates regeneration in cirrhotic mouse livers after hepatectomy

31 March 2020

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A mechanism of cell survival: sequestration of Fas by the HGF receptor Met.

31 March 2020

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Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1.

31 March 2020

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High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes

31 March 2020

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Gene expression of regulatory enzymes of glycolysis/gluconeogenesis in regenerating rat liver

31 March 2020

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Coexistence of C/EBP alpha, beta, growth-induced proteins and DNA synthesis in hepatocytes during liver regeneration. Implications for maintenance of the differentiated state during liver growth

31 March 2020

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Growth-dependent inhibition of CCAAT enhancer-binding protein (C/EBP alpha) gene expression during hepatocyte proliferation in the regenerating liver and in culture

31 March 2020

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The extracellular matrix in hepatic regeneration.

31 March 2020

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Plasminogen activators direct reorganization of the liver lobule after acute injury

31 March 2020

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Expression of suppressors of cytokine signaling during liver regeneration

31 March 2020

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Hyperstimulation with interleukin 6 inhibits cell cycle progression after hepatectomy in mice

31 March 2020

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

31 March 2020

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Norepinephrine modulates the growth-inhibitory effect of transforming growth factor-beta in primary rat hepatocyte cultures

31 March 2020

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Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration

31 March 2020

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Differential regulation of activin A for hepatocyte growth and fibronectin synthesis in rat liver injury

31 March 2020

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Adenovirus-mediated overexpression of follistatin enlarges intact liver of adult rats

31 March 2020

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Donor evaluation, donor risks, donor outcome, and donor quality of life in adult-to-adult living donor liver transplantation

31 March 2020

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Hepatic regeneration in living donor liver transplantation

31 March 2020

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Timing of hepatocyte entry into DNA synthesis after partial hepatectomy is cell autonomous

31 March 2020

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Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM1489

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PubMed ID

15459664

Dimensions Publication ID

1 August 2017

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PubMed ID

15459664