Smad-dependent and Smad-independent pathways in TGF-beta family signalling (Q28208250)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14534577%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

review article

1 reference

title

Smad-dependent and Smad-independent pathways in TGF-beta family signalling (English)

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19 December 2019

2

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19 December 2019

author name string

Rik Derynck

series ordinal

1

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19 December 2019

language of work or name

English

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publication date

1 October 2003

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19 December 2019

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19 December 2019

volume

425

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19 December 2019

page(s)

577-584

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19 December 2019

issue

6958

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How cells read TGF-beta signals

19 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Signaling of transforming growth factor-beta family members through Smad proteins

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Identification of two Smad4 proteins in Xenopus. Their common and distinct properties.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

A new Smurf in the village.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Internalization-dependent and -independent requirements for transforming growth factor beta receptor signaling via the Smad pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Microtubule binding to Smads may regulate TGF beta activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Filamin associates with Smads and regulates transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Crystal Structure of a Phosphorylated Smad2

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Stoichiometry of active smad-transcription factor complexes on DNA

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Phosphorylation of Smad7 at Ser-249 does not interfere with its inhibitory role in transforming growth factor-beta-dependent signaling but affects Smad7-dependent transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Control of Smad7 stability by competition between acetylation and ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Nuclear exclusion of Smad2 is a mechanism leading to loss of competence

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Regulation of Smad signaling by protein kinase C

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Eukaryotic initiation factor 2 alpha subunit associates with TGF beta receptors and 14-3-3 epsilon and acts as a modulator of the TGF beta response

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

FKBP12 is a negative regulator of transforming growth factor-beta receptor internalization

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Interaction of transforming growth factor-beta receptor I with farnesyl-protein transferase-alpha in yeast and mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

IAP proteins: blocking the road to death's door

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Evidence for a role of the JNK cascade in Smad7-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Rho GTPases and their effector proteins

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

A component of the ARC/Mediator complex required for TGF beta/Nodal signalling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02006

7 January 2021

Identifiers

DOI

10.1038/NATURE02006

2 references

Consolidated OpenCitations Corpus – April 2017

333740

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14534577%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

19 December 2019

1009326672

0 references

333740

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

333740

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14534577%20AND%20SRC:MED&resulttype=core&format=json