Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions. (Q34360051)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25157098%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

title

Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25157098%20AND%20SRC:MED&resulttype=core&format=json

protein-protein interaction

13 March 2020

main subject

1 reference

1

1 reference

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13 March 2020

author name string

Donald J Tweedie

series ordinal

2

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13 March 2020

Tom S Chan

series ordinal

3

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13 March 2020

Timothy S Tracy

series ordinal

4

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13 March 2020

publication date

25 August 2014

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Drug Metabolism and Disposition

13 March 2020

published in

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13 March 2020

volume

42

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13 March 2020

issue

11

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13 March 2020

page(s)

1940-1946

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Generating an in vitro-in vivo correlation for metabolism and liver enrichment of a hepatitis C virus drug, faldaprevir, using a rat hepatocyte model (HepatoPac).

13 March 2020

cites work

1 reference

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Mechanisms that regulate production of reactive oxygen species by cytochrome P450.

6 July 2018

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The many roles of cytochrome b5

6 July 2018

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Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes

6 July 2018

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Regulation of cytochrome p450 by inflammatory mediators: why and how?

6 July 2018

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Regulation of cytochrome P450 (CYP) genes by nuclear receptors.

6 July 2018

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Interactions between cytochrome P450 and cytochrome b5.

6 July 2018

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

6 July 2018

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Regulation of cytochromes P450 during inflammation and infection.

6 July 2018

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Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions.

6 July 2018

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Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components

6 July 2018

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6 July 2018

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Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac.

6 July 2018

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Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants.

27 October 2018

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Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac

27 October 2018

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Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.

27 October 2018

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Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites

27 October 2018

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27 October 2018

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27 October 2018

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27 October 2018

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27 October 2018

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Microscale culture of human liver cells for drug development

27 October 2018

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27 October 2018

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In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin.

27 October 2018

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Cytochrome P-450 isozyme/isozyme functional interactions and NADPH-cytochrome P-450 reductase concentrations as factors in microsomal metabolism of warfarin

27 October 2018

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12 December 2020

Competitive interactions between cytochromes P450 2A6 and 2E1 for NADPH-cytochrome P450 oxidoreductase in the microsomal membranes produced by a baculovirus expression system

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12 December 2020

Competition between cytochrome P-450 isozymes for NADPH-cytochrome P-450 oxidoreductase affects drug metabolism

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12 December 2020

Human hepatic cell cultures: in vitro and in vivo drug metabolism

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12 December 2020

Coimmunoprecipitation of UDP-glucuronosyltransferase isoforms and cytochrome P450 3A4

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12 December 2020

Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer

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12 December 2020

Identifiers

DOI

10.1124/DMD.114.057901

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25157098%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25157098%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

PubMed publication ID

25157098

1 reference