Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits (Q34367882)

1 August 2017

title

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits (English)

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1 August 2017

6

Heidi C E Welch

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1 August 2017

Sonja Krugmann

2

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Leonard R. Stephens

object named as

Len R Stephens

series ordinal

8

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Phillip Thomas Hawkins

object named as

Phillip T Hawkins

series ordinal

7

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Kirsti Hill

series ordinal

1

object named as

Kirsti Hill

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1 August 2017

4

W John Coadwell

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1 August 2017

5

Peter Finan

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1 August 2017

Simon R Andrews

3

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1 August 2017

language of work or name

English

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publication date

15 November 2004

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Journal of Biological Chemistry

1 August 2017

published in

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1 August 2017

volume

280

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1 August 2017

issue

6

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1 August 2017

page(s)

4166-4173

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P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

1 August 2017

cites work

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Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.

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G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production

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Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.

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Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits

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Sites important for PLCbeta2 activation by the G protein betagamma subunit map to the sides of the beta propeller structure

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Sites for Galpha binding on the G protein beta subunit overlap with sites for regulation of phospholipase Cbeta and adenylyl cyclase

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PDZ domains-glue and guide.

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The Isolation and Characterization of cDNA Encoding Human and Rat Brain Inositol Polyphosphate 4-Phosphatase

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A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice

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Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

21 January 2018

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Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

21 January 2018

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Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins

21 January 2018

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21 January 2018

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SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling

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NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio

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Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

21 January 2018

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PIP(2)-PDZ domain binding controls the association of syntenin with the plasma membrane

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M411262200

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1 August 2017

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