Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling (Q34378552)

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16 January 2020

title

Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling (English)

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6

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Anthony R Green

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author name string

Edwin Chen

1

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Philip A Beer

2

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Anna L Godfrey

3

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Christina A Ortmann

4

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Juan Li

5

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Catherine E Ingle

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Emmanouil T Dermitzakis

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Peter J Campbell

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publication date

1 November 2010

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16 January 2020

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volume

18

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issue

5

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page(s)

524-535

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Transcriptional profiling of polycythemia vera identifies gene expression patterns both dependent and independent from the action of JAK2V617F.

16 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996868

JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation

6 July 2018

1 reference

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Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells

6 July 2018

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Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection

6 July 2018

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JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia

6 July 2018

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Functional crosstalk between type I and II interferon through the regulated expression of STAT1.

6 July 2018

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Interferon-alpha targets JAK2V617F-positive hematopoietic progenitor cells and acts through the p38 MAPK pathway

6 July 2018

1 reference

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Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease

6 July 2018

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STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant

6 July 2018

1 reference

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Expression quantitative trait loci are highly sensitive to cellular differentiation state

6 July 2018

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Polycythemia vera erythroid precursors exhibit increased proliferation and apoptosis resistance associated with abnormal RAS and PI3K pathway activation

6 July 2018

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JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

6 July 2018

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Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a

6 July 2018

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INTERFEROME: the database of interferon regulated genes

6 July 2018

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Genetical genomics: spotlight on QTL hotspots

6 July 2018

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Downregulation of signal transducer and activator of transcription 5 (STAT5) in CD34+ cells promotes megakaryocytic development, whereas activation of STAT5 drives erythropoiesis

6 July 2018

1 reference

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Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability

6 July 2018

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Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice

6 July 2018

1 reference

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Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2.

6 July 2018

1 reference

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Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F.

6 July 2018

1 reference

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STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice

6 July 2018

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Relative impact of nucleotide and copy number variation on gene expression phenotypes

6 July 2018

1 reference

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Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis.

6 July 2018

1 reference

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JAK signaling globally counteracts heterochromatic gene silencing

6 July 2018

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JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.

6 July 2018

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Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants

6 July 2018

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The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation

6 July 2018

1 reference

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Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model

6 July 2018

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X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoies

6 July 2018

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Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation

6 July 2018

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Genome-wide associations of gene expression variation in humans

6 July 2018

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Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study.

6 July 2018

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Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2.

6 July 2018

1 reference

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Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia

6 July 2018

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A gain-of-function mutation of JAK2 in myeloproliferative disorders

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996868

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

6 July 2018

1 reference

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Gene expression profiling in polycythaemia vera: overexpression of transcription factor NF-E2.

6 July 2018

1 reference

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

6 July 2018

1 reference

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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

6 July 2018

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Analysis of oligonucleotide array experiments with repeated measures using mixed models

6 July 2018

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Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction

6 July 2018

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Dominant negative mutants implicate STAT5 in myeloid cell proliferation and neutrophil differentiation

6 July 2018

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Jak2 is essential for signaling through a variety of cytokine receptors

6 July 2018

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Targeted inhibition of interferon-gamma-dependent intercellular adhesion molecule-1 (ICAM-1) expression using dominant-negative Stat1.

6 July 2018

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The Janus kinase family and signaling through members of the cytokine receptor superfamily

6 July 2018

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Interferon-induced nuclear signalling by Jak protein tyrosine kinases

6 July 2018

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Polycythemia vera: stem-cell and probable clonal origin of the disease

6 July 2018

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Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice.

6 July 2018

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Brief report: interferon-gamma induces expansion of Lin(-)Sca-1(+)C-Kit(+) Cells.

27 October 2018

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Phospho-STAT5 and phospho-Akt expression in chronic myeloproliferative neoplasms.

27 October 2018

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IFNalpha activates dormant haematopoietic stem cells in vivo.

27 October 2018

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Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice

27 October 2018

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Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F.

27 October 2018

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Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia.

27 October 2018

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Gene expression profiling of normal and malignant CD34-derived megakaryocytic cells

27 October 2018

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Gene expression profiling in polycythemia vera using cDNA microarray technology.

27 October 2018

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Awakening dormant haematopoietic stem cells

27 October 2018

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Gene expression profiling distinguishes JAK2V617F-negative from JAK2V617F-positive patients in essential thrombocythemia

9 December 2018

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JAK2V617F mutation in platelets from essential thrombocythemia patients: correlation with clinical features and analysis of STAT5 phosphorylation status

9 December 2018

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12 December 2020

Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells

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12 December 2020

Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation

1 reference

12 December 2020

The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera

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12 December 2020

Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell

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12 December 2020

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