Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A. (Q34379603)

1 August 2017

Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A. (English)

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1 August 2017

Toshimasa Takahashi

1

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1 August 2017

Tadao Shibasaki

2

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1 August 2017

Harumi Takahashi

3

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1 August 2017

Kenji Sugawara

4

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1 August 2017

Aika Ono

5

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1 August 2017

Naoko Inoue

6

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1 August 2017

Toshio Furuya

7

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1 August 2017

Susumu Seino

8

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1 August 2017

22 October 2013

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1 August 2017

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1 August 2017

6

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1 August 2017

298

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1 August 2017

ra94

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Cyclic nucleotide research -- still expanding after half a century

1 August 2017

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

A family of cAMP-binding proteins that directly activate Rap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Spatial control of Epac2 activity by cAMP and Ca2+-mediated activation of Ras in pancreatic β cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Epac proteins: multi-purpose cAMP targets

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Structure and regulation of the cAMP-binding domains of Epac2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Triggering and amplifying pathways of regulation of insulin secretion by glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

ASEDock-docking based on alpha spheres and excluded volumes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

The Amber biomolecular simulation programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

The biology of incretin hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

ATP-sensitive potassium channelopathies: focus on insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

KATP channels as molecular sensors of cellular metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Sulfonylurea action re-revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Epac2: a molecular target for sulfonylurea-induced insulin release

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Epac2: a sulfonylurea receptor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Exchange protein directly activated by cyclic AMP isoform 2 is not a direct target of sulfonylurea drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Scalable molecular dynamics with NAMD

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Solvated interaction energy (SIE) for scoring protein-ligand binding affinities. 1. Exploring the parameter space.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004581

10.1126/SCISIGNAL.2004581

21 January 2018

Identifiers

DOI

1 reference

1 August 2017

1 reference