Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats (Q34386625)

1 August 2017

Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats (English)

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1 August 2017

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9

Tim Vanuytsel

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Wim J Laleman

11

Wim Laleman

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Jonel Trebicka

Jonel Trebicka

3

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Ricard Farre

Ricard Farre

2

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Tania Roskams

5

Tania Roskams

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1 August 2017

Len Verbeke

1

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1 August 2017

Mina Komuta

4

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1 August 2017

Sabine Klein

6

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1 August 2017

Ingrid Vander Elst

7

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1 August 2017

Petra Windmolders

8

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1 August 2017

Frederik Nevens

10

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1 August 2017

language of work or name

English

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publication date

14 April 2014

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1 August 2017

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1 August 2017

59

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1 August 2017

6

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1 August 2017

2286-2298

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Portal hypertension: from pathophysiology to clinical practice

1 August 2017

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Natural history of cirrhosis.

21 January 2018

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Clinical course of alcoholic liver cirrhosis: a Danish population-based cohort study

21 January 2018

1 reference

Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: a controlled study

21 January 2018

1 reference

Propranolol in the prevention of first upper gastrointestinal tract hemorrhage in patients with cirrhosis of the liver and esophageal varices

21 January 2018

1 reference

Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis.

21 January 2018

1 reference

Deleterious effects of beta-blockers on survival in patients with cirrhosis and refractory ascites

21 January 2018

1 reference

Functional aspects on the pathophysiology of portal hypertension in cirrhosis

21 January 2018

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In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats

21 January 2018

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A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis

21 January 2018

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Superoxide dismutase gene transfer reduces portal pressure in CCl4 cirrhotic rats with portal hypertension.

21 January 2018

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Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers

21 January 2018

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HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects.

21 January 2018

1 reference

Critical illness evokes elevated circulating bile acids related to altered hepatic transporter and nuclear receptor expression

21 January 2018

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Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response

21 January 2018

1 reference

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

21 January 2018

1 reference

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

21 January 2018

1 reference

Role of bile acids and bile acid receptors in metabolic regulation

21 January 2018

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Inhibition of endothelin-1-mediated contraction of hepatic stellate cells by FXR ligand

21 January 2018

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Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts

21 January 2018

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FXR-mediated regulation of eNOS expression in vascular endothelial cells

21 January 2018

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Farnesoid X receptor agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulation

21 January 2018

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Analyzing real-time PCR data by the comparative C(T) method

21 January 2018

1 reference

Amelioration of portal hypertension and the hyperdynamic circulatory syndrome in cirrhotic rats by neuropeptide Y via pronounced splanchnic vasoaction.

21 January 2018

1 reference

Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase

21 January 2018

1 reference

Identification of a nuclear receptor for bile acids

21 January 2018

1 reference

Bile acids: natural ligands for an orphan nuclear receptor

21 January 2018

1 reference

Increased activation of the Wnt/β-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice

21 January 2018

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Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis

21 January 2018

1 reference

Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet

21 January 2018

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Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis.

21 January 2018

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Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

21 January 2018

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6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

21 January 2018

1 reference

Bile acids regulate cardiovascular function

21 January 2018

1 reference

The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough

21 January 2018

1 reference

Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats.

21 January 2018

1 reference

Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension

21 January 2018

1 reference

Meta-analysis: isosorbide-mononitrate alone or with either beta-blockers or endoscopic therapy for the management of oesophageal varices.

21 January 2018

1 reference

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

21 January 2018

1 reference

Dimethylarginine dimethylaminohydrolase-2 overexpression improves impaired nitric oxide synthesis of endothelial cells induced by glycated protein

21 January 2018

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FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats

21 January 2018

1 reference

Bench-to-beside review: acute-on-chronic liver failure - linking the gut, liver and systemic circulation

21 January 2018

1 reference

Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats

21 January 2018

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Embolization of large spontaneous portosystemic shunts for refractory hepatic encephalopathy: a multicenter survey on safety and efficacy

21 January 2018

1 reference

7 January 2021

Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage

1 reference

7 January 2021

Relation between portal pressure response to pharmacotherapy and risk of recurrent variceal haemorrhage in patients with cirrhosis

1 reference

7 January 2021

Microparticles and paracrine signaling in portal hypertension: crucial conversations or idle chat?

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7 January 2021

Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary culture

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7 January 2021

Both Ca2+ -dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine

1 reference

7 January 2021

Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension

1 reference

7 January 2021

Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat

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7 January 2021

A stable model of cirrhotic portal hypertension in the rat: thioacetamide revisited

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7 January 2021

Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase

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7 January 2021

Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration

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7 January 2021

Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine

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7 January 2021

Identifiers

DOI

10.1002/HEP.26939

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1 August 2017

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