Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models (Q34391423)

1 August 2017

title

Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models (English)

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1 August 2017

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Anders W Ohman

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Ronny Drapkin

object named as

Ronny Drapkin

16

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author name string

Ruth Perets

1

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1 August 2017

Gregory A Wyant

2

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1 August 2017

Katherine W Muto

3

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1 August 2017

Jonathan G Bijron

4

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Barish B Poole

5

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Kenneth T Chin

6

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Jin Yun H Chen

7

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Corey D Stepule

9

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1 August 2017

Soongu Kwak

10

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1 August 2017

Alison M Karst

11

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1 August 2017

Michelle S Hirsch

12

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1 August 2017

Sunita R Setlur

13

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Christopher P Crum

14

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1 August 2017

Daniela M Dinulescu

15

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1 August 2017

publication date

1 December 2013

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1 August 2017

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1 August 2017

volume

24

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1 August 2017

issue

6

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1 August 2017

page(s)

751-765

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Early telomere shortening and genomic instability in tubo-ovarian preneoplastic lesions.

1 August 2017

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Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer

6 July 2018

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High-grade serous ovarian cancer arises from fallopian tube in a mouse model

6 July 2018

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An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

6 July 2018

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Molecular requirements for transformation of fallopian tube epithelial cells into serous carcinoma

6 July 2018

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6 July 2018

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6 July 2018

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Stathmin 1, a marker of PI3K pathway activation and regulator of microtubule dynamics, is expressed in early pelvic serous carcinomas.

6 July 2018

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6 July 2018

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Modeling high-grade serous ovarian carcinogenesis from the fallopian tube

6 July 2018

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6 July 2018

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Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo.

6 July 2018

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6 July 2018

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PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma

6 July 2018

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Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary

6 July 2018

1 reference

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Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53.

6 July 2018

1 reference

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Conditional inactivation of Brca1, p53 and Rb in mouse ovaries results in the development of leiomyosarcomas

6 July 2018

1 reference

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Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling

6 July 2018

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

6 July 2018

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New insights into the pathogenesis of serous ovarian cancer and its clinical impact

6 July 2018

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6 July 2018

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A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations

6 July 2018

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A candidate precursor to serous carcinoma that originates in the distal fallopian tube.

6 July 2018

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6 July 2018

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Status of Tumor Markers in Ovarian Cancer Screening

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Germ-line p53 mutations predispose to a wide spectrum of early-onset cancers.

6 July 2018

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Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers

6 July 2018

1 reference

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6 July 2018

1 reference

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

6 July 2018

1 reference

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6 July 2018

1 reference

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High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression.

6 July 2018

1 reference

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Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.

27 October 2018

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Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship.

27 October 2018

1 reference

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Congenital hypothyroid female pax8-deficient mice are infertile despite thyroid hormone replacement therapy.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917315

Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3917315

Emerging roles for PAX8 in ovarian cancer and endosalpingeal development.

27 October 2018

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The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome.

27 October 2018

1 reference

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Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer

27 October 2018

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Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium.

27 October 2018

1 reference

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Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

27 October 2018

1 reference

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BRCA1 CpG Island Hypermethylation Predicts Sensitivity to Poly(Adenosine Diphosphate)- Ribose Polymerase Inhibitors

27 October 2018

1 reference

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Are All Pelvic (Nonuterine) Serous Carcinomas of Tubal Origin?

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24332043

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24332043

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The tubal hypothesis of ovarian cancer: caution needed

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24332043

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2013.10.013

1 reference

1 August 2017

1 reference

1 August 2017

1 reference