Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates. (Q34395100)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927435%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates (English)

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12 February 2020

1 reference

1

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12 February 2020

7

Gregg B Fields

1 reference

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12 February 2020

author name string

Mare Cudic

2

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12 February 2020

Nina Bionda

3

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12 February 2020

Marc Giulianotti

4

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12 February 2020

Laura Maida

5

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12 February 2020

Richard A Houghten

6

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12 February 2020

language of work or name

English

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publication date

27 August 2012

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12 February 2020

number of pages

15

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Journal of Biological Chemistry

inferred from page(s)

published in

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12 February 2020

volume

287

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12 February 2020

issue

43

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12 February 2020

page(s)

36473-36487

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Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.

12 February 2020

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Cross-domain inhibition of TACE ectodomain

6 July 2018

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Use and implications of the harmonic mean model on mixtures for basic research and drug discovery

6 July 2018

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The soluble Interleukin 6 receptor: generation and role in inflammation and cancer

6 July 2018

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Acetylenic inhibitors of ADAM10 and ADAM17: in silico analysis of potency and selectivity

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Fluorescent substrates useful as high-throughput screening tools for ADAM9.

6 July 2018

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EGFR ligands and their signaling scissors, ADAMs, as new molecular targets for anticancer treatments

6 July 2018

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Structure-based discovery of small molecules targeting different surfaces of protein-kinase CK2.

6 July 2018

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Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10

6 July 2018

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Structural and functional bases for allosteric control of MMP activities: can it pave the path for selective inhibition?

6 July 2018

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Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins

6 July 2018

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Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

6 July 2018

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News from an ancient world: two novel astacin metalloproteases from the horseshoe crab

6 July 2018

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Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge

6 July 2018

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The ADAM metalloproteinases

6 July 2018

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Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor

6 July 2018

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The activity of HDAC8 depends on local and distal sequences of its peptide substrates

6 July 2018

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Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis

6 July 2018

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High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate

6 July 2018

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ADAM10 as a target for anti-cancer therapy

6 July 2018

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Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods

6 July 2018

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Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.

6 July 2018

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The structure of the flexible arm ofThermotoga maritimatRNase Z differs from those of homologous enzymes

6 July 2018

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Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects

6 July 2018

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Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket

6 July 2018

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Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences

6 July 2018

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Matrix metalloproteinases as valid clinical targets

6 July 2018

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Targeting TACE-dependent EGFR ligand shedding in breast cancer

6 July 2018

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The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity

6 July 2018

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A common allosteric site and mechanism in caspases

6 July 2018

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The tRNase Z family of proteins: physiological functions, substrate specificity and structural properties

6 July 2018

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Structural basis for the highly selective inhibition of MMP-13.

6 July 2018

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Modes of inhibition of cysteine proteases.

6 July 2018

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Conformation of Glycopeptides

6 July 2018

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Synthesis and biological activity of piperazine-based dual MMP-13 and TNF-alpha converting enzyme inhibitors

6 July 2018

1 reference

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Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase

6 July 2018

1 reference

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Advances in the use of synthetic combinatorial chemistry: mixture-based libraries

6 July 2018

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Conformational studies of oligosaccharides and glycopeptides: complementarity of NMR, X-ray crystallography, and molecular modelling

6 July 2018

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A novel exosite on coagulation factor VIIa and its molecular interactions with a new class of peptide inhibitors

6 July 2018

1 reference

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Pterin interactions with distinct reductase activities of NO synthase

6 July 2018

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Sweet is stable: glycosylation stabilizes collagen.

6 July 2018

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Peptide exosite inhibitors of factor VIIa as anticoagulants

6 July 2018

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Mixture-based synthetic combinatorial libraries.

6 July 2018

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Identification of highly selective inhibitors of collagenase-1 from combinatorial libraries of diketopiperazines

6 July 2018

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TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha

6 July 2018

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O-glycosylated species of natural human tumor-necrosis factor-alpha

6 July 2018

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Conformational implications of asparagine-linked glycosylation

6 July 2018

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A general approach to the synthesis of O- and N-linked glycopeptides.

6 July 2018

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Fusion of two distinct peptide exosite inhibitors of Factor VIIa

6 July 2018

1 reference

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Engineering functional antithrombin exosites in alpha1-proteinase inhibitor that specifically promote the inhibition of factor Xa and factor IXa.

21 January 2018

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A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.

21 January 2018

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Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).

21 January 2018

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Manipulation of thrombin exosite I, by ligand-directed covalent modification

21 January 2018

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Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases.

21 January 2018

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Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening.

21 January 2018

1 reference

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Site-dependent effect of O-glycosylation on the conformation and biological activity of calcitonin

21 January 2018

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Different transforming growth factor-alpha species are derived from a glycosylated and palmitoylated transmembrane precursor

21 January 2018

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Analysis of the combined effect of two linear inhibitors on a single enzyme

21 January 2018

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Multiple glycosylation of de novo designed alpha-helical coiled coil peptides

21 January 2018

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Fast calculation of van der Waals volume as a sum of atomic and bond contributions and its application to drug compounds

21 January 2018

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Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.

21 January 2018

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Enhanced FTase activity achieved via piperazine interaction with catalytic zinc

21 January 2018

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Disulfide Bond Structure andN-Glycosylation Sites of the Extracellular Domain of the Human Interleukin-6 Receptor

21 January 2018

1 reference

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Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability

21 January 2018

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12 December 2020

ADAM8 substrate specificity: influence of pH on pre-processing and proteoglycan degradation

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12 December 2020

Crystal structure of RVV-X: an example of evolutionary gain of specificity by ADAM proteinases

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12 December 2020

The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site

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12 December 2020

Conformational studies by NMR of the antimicrobial peptide, drosocin, and its non-glycosylated derivative: effects of glycosylation on solution conformation

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12 December 2020

MT1-MMP is required for efficient tumor dissemination in experimental metastatic disease

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12 December 2020

Identifiers

DOI

10.1074/JBC.M112.389114

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927435%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927435%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference