The LQLP calcineurin docking site is a major determinant of the calcium-dependent activation of human TRESK background K+ channel (Q34396710)

25202008

1 August 2017

title

The LQLP calcineurin docking site is a major determinant of the calcium-dependent activation of human TRESK background K+ channel (English)

1 reference

1 August 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202008%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Péter Enyedi

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202008%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

language of work or name

English

0 references

publication date

8 September 2014

1 reference

25202008

Journal of Biological Chemistry

1 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202008%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

289

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202008%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

43

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202008%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

29506-29518

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202008%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

1 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4207969/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Tubulin binds to the cytoplasmic loop of TRESK background K⁺ channel in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Over-expression of TRESK K(+) channels reduces the excitability of trigeminal ganglion nociceptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Functional characterization of zebrafish K2P18.1 (TRESK) two-pore-domain K+ channels.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Functional analysis of a migraine-associated TRESK K+ channel mutation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

A calcineurin docking motif (LXVP) in dynamin-related protein 1 contributes to mitochondrial fragmentation and ischemic neuronal injury.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

A Role for K2P Channels in the Operation of Somatosensory Nociceptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Leak K⁺ channel mRNAs in dorsal root ganglia: relation to inflammation and spontaneous pain behaviour

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

TRESK background K(+) channel is inhibited by PAR-1/MARK microtubule affinity-regulating kinases in Xenopus oocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Molecular regulations governing TREK and TRAAK channel functions.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

TRESK channel contribution to nociceptive sensory neurons excitability: modulation by nerve injury.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Interaction of calcineurin with substrates and targeting proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Discrete change in volatile anesthetic sensitivity in mice with inactivated tandem pore potassium ion channel TRESK.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Ion channels as novel therapeutic targets in the treatment of pain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Gating of two pore domain potassium channels.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Molecular background of leak K+ currents: two-pore domain potassium channels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

TRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Cracking the phosphatase code: docking interactions determine substrate specificity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in yeast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

NFAT proteins: key regulators of T-cell development and function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Inhibition of NFATx activation by an oligopeptide: disrupting the interaction of NFATx with calcineurin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

A second calcineurin binding site on the NFAT regulatory domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Two-site interaction of nuclear factor of activated T cells with activated calcineurin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Mechanism of release of Ca2+ from intracellular stores in response to ionomycin in oocytes of the frog Xenopus laevis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK.

6 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.577684

Identifying the Ca(++) signalling sources activating chloride currents in Xenopus oocytes using ionomycin and thapsigargin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.577684

TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.577684

TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.577684

Intrathecal TRESK gene recombinant adenovirus attenuates spared nerve injury-induced neuropathic pain in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.577684

Lamotrigine inhibits TRESK regulated by G-protein coupled receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.577684

Two independent calcineurin-binding regions in the N-terminal domain of murine NF-ATx1 recruit calcineurin to murine NF-ATx1.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207969

Blockade of NFAT activation by the second calcineurin binding site

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25202008

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25202008

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M114.577684

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202008%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202008%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

25202008

1 reference