NFAT proteins: key regulators of T-cell development and function (Q28253919)

Europe PubMed Central

title

NFAT proteins: key regulators of T-cell development and function (English)

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main subject

NFAT protein binding

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0051525

calcineurin-NFAT signaling cascade

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Gene Ontology release 2020-05-02

1

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language of work or name

English

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publication date

June 2005

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published in

Nature Reviews Immunology

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volume

5

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page(s)

472-84

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issue

6

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cites work

Transcription factors of the NFAT family: regulation and function

1 reference

NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun

21 April 2017

1 reference

Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity

21 April 2017

1 reference

Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor

21 April 2017

1 reference

Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress

21 April 2017

1 reference

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

21 April 2017

1 reference

Two-site interaction of nuclear factor of activated T cells with activated calcineurin

21 April 2017

1 reference

Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT

21 April 2017

1 reference

A second calcineurin binding site on the NFAT regulatory domain

21 April 2017

1 reference

Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes

21 April 2017

1 reference

AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region

21 April 2017

1 reference

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling

21 April 2017

1 reference

Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells

21 April 2017

1 reference

Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

21 April 2017

1 reference

Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3

21 April 2017

1 reference

Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway

21 April 2017

1 reference

Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1

21 April 2017

1 reference

Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases

21 April 2017

1 reference

Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells

21 April 2017

1 reference

Structure of NFAT bound to DNA as a monomer

21 April 2017

1 reference

Mammalian MAP kinase signalling cascades

21 April 2017

1 reference

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

21 April 2017

1 reference

CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1

21 April 2017

1 reference

Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes

21 April 2017

1 reference

Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression

21 April 2017

1 reference

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

21 April 2017

1 reference

Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression

21 April 2017

1 reference

Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis

21 April 2017

1 reference

Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element

21 April 2017

1 reference

An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site

21 April 2017

1 reference

A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis

21 April 2017

1 reference

Defective T cell development and function in calcineurin A beta -deficient mice

21 April 2017

1 reference

The transcription factor NFAT4 is involved in the generation and survival of T cells

21 April 2017

1 reference

A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells

21 April 2017

1 reference

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

21 April 2017

1 reference

NFATc2-mediated repression of cyclin-dependent kinase 4 expression

21 April 2017

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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

21 April 2017

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GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells

21 April 2017

1 reference

Transcriptional regulation by calcium, calcineurin, and NFAT

21 April 2017

1 reference

The lineage decisions of helper T cells

21 April 2017

1 reference

Identification of a putative regulator of early T cell activation genes

21 April 2017

1 reference

NFAT signaling in vertebrate development

31 March 2020

1 reference

NFAT signaling: choreographing the social lives of cells

31 March 2020

1 reference

Expression and regulation of NFAT (nuclear factors of activated T cells) in human CD34+ cells: down-regulation upon myeloid differentiation

31 March 2020

1 reference

NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment

31 March 2020

1 reference

Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes

31 March 2020

1 reference

Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc

31 March 2020

1 reference

Ca2+/calcineurin signalling in cells of the immune system

31 March 2020

1 reference

Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

31 March 2020

1 reference

Structural delineation of the calcineurin-NFAT interaction and its parallels to PP1 targeting interactions

31 March 2020

1 reference

Inhibition of NFATx activation by an oligopeptide: disrupting the interaction of NFATx with calcineurin

31 March 2020

1 reference

Association of protein kinase A and protein phosphatase 2B with a common anchoring protein

31 March 2020

1 reference

Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein

31 March 2020

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The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin

31 March 2020

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c-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1.

31 March 2020

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A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.

31 March 2020

1 reference

A role for the p38 MAP kinase pathway in the nuclear shuttling of NFATp

31 March 2020

1 reference

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction

31 March 2020

1 reference

Regulation of the murine Nfatc1 gene by NFATc2.

31 March 2020

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Transcriptional mechanisms underlying lymphocyte tolerance.

31 March 2020

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Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 through selective NFAT1- and NFAT2-dependent mechanisms

31 March 2020

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Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation

31 March 2020

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Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1.

31 March 2020

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Partners in transcription: NFAT and AP-1.

31 March 2020

1 reference

Nuclear factor of activated T cells contains Fos and Jun.

31 March 2020

1 reference

Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun.

31 March 2020

1 reference

Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels

31 March 2020

1 reference

Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1.

31 March 2020

1 reference

CD28-mediated co-stimulation: a quantitative support for TCR signalling

31 March 2020

1 reference

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

31 March 2020

1 reference

CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells

31 March 2020

1 reference

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

31 March 2020

1 reference

T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes.

31 March 2020

1 reference

A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I-hypersensitive site.

31 March 2020

1 reference

The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

31 March 2020

1 reference

Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein

31 March 2020

1 reference

A Distal Enhancer in the Interferon-γ (IFN-γ) Locus Revealed by Genome Sequence Comparison

31 March 2020

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Transcription cooperation by NFAT.C/EBP composite enhancer complex.

31 March 2020

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Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT.

31 March 2020

1 reference

The structure of the NF-kappa B p50:DNA-complex: a starting point for analyzing the Rel family.

31 March 2020

1 reference

Expression of NFAT-family proteins in normal human T cells

31 March 2020

1 reference

Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis

31 March 2020

1 reference

Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

31 March 2020

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An enhanced immune response in mice lacking the transcription factor NFAT1.

31 March 2020

1 reference

The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

31 March 2020

1 reference

Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc

31 March 2020

1 reference

Positive and negative selection of T cells

31 March 2020

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Thymic selection revisited: how essential is it?

31 March 2020

1 reference

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT

31 March 2020

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Effects of cyclosporine A on T cell development and clonal deletion

31 March 2020

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Abnormal differentiation of thymocytes in mice treated with cyclosporin A.

31 March 2020

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Calcineurin B1 is essential for positive but not negative selection during thymocyte development

31 March 2020

1 reference

Effects of a constitutively active form of calcineurin on T cell activation and thymic selection

31 March 2020

1 reference

Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

31 March 2020

1 reference

NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells

31 March 2020

1 reference

Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice

31 March 2020

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Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

31 March 2020

1 reference

An epigenetic view of helper T cell differentiation

31 March 2020

1 reference

Molecular mechanisms regulating Th1 immune responses

31 March 2020

1 reference

Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo

31 March 2020

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Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity

31 March 2020

1 reference

Chromatin-level regulation of the IL10 gene in T cells.

31 March 2020

1 reference

Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1

31 March 2020

1 reference

Regulation of interferon-gamma gene expression by nuclear factor of activated T cells

31 March 2020

1 reference

NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription

31 March 2020

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Sustained NFAT signaling promotes a Th1-like pattern of gene expression in primary murine CD4+ T cells

31 March 2020

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Transcriptional regulation of th2 differentiation by inducible costimulator.

31 March 2020

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Activation changes the spectrum but not the diversity of genes expressed by T cells.

31 March 2020

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The duration of nuclear residence of NFAT determines the pattern of cytokine expression in human SCID T cells

31 March 2020

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NFATc1 and NFATc2 together control both T and B cell activation and differentiation

31 March 2020

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Gene regulation mediated by calcium signals in T lymphocytes

31 March 2020

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NFATC2 transcription factor regulates cell cycle progression during lymphocyte activation: evidence of its involvement in the control of cyclin gene expression

31 March 2020

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31 March 2020

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31 March 2020

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Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

31 March 2020

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31 March 2020

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NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells

31 March 2020

1 reference

From cyclosporine to the future

31 March 2020

1 reference

Immunosuppression: practice and trends

31 March 2020

1 reference

The treatment of lupus with cyclosporin A.

31 March 2020

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Manipulating immune responses with immunosuppressive agents that target NFAT.

31 March 2020

1 reference

Nephrotoxicity of immunosuppressive drugs: new insight and preventive strategies

31 March 2020

1 reference

A new cell-permeable peptide allows successful allogeneic islet transplantation in mice

31 March 2020

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The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT.

31 March 2020

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Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules

31 March 2020

1 reference