A single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains. (Q34414463)

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English	A single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains.	scientific article

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scholarly article

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22 February 2020

A single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains (English)

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22 February 2020

membrane proteins

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based on heuristic

inferred from title

Herpes simplex virus type 1

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based on heuristic

inferred from title

Human herpesvirus 2

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based on heuristic

inferred from title

Brent A. Stanfield

1

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22 February 2020

Konstantin G Kousoulas

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Konstantin G Kousoulas

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22 February 2020

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Jacque Stahl

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22 February 2020

Vladimir N Chouljenko

3

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22 February 2020

Ramesh Subramanian

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22 February 2020

Anu-Susan Charles

5

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22 February 2020

Ahmad A Saied

6

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22 February 2020

Jason D Walker

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28 October 2014

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22 February 2020

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22 February 2020

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22 February 2020

e109890

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22 February 2020

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Creative Commons Attribution 4.0 International

28 October 2014

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0 references

Overexpression of herpes simplex virus glycoprotein K (gK) alters expression of HSV receptors in ocularly-infected mice

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Single dose of glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses

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Herpes simplex virus 1 glycoprotein M and the membrane-associated protein UL11 are required for virus-induced cell fusion and efficient virus entry

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A herpes simplex virus 1 (McKrae) mutant lacking the glycoprotein K gene is unable to infect via neuronal axons and egress from neuronal cell bodies

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Live attenuated herpes simplex virus 2 glycoprotein E deletion mutant as a vaccine candidate defective in neuronal spread

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Herpes simplex virus type 2 infection increases human immunodeficiency virus type 1 entry into human primary macrophages

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A live-attenuated HSV-2 ICP0 virus elicits 10 to 100 times greater protection against genital herpes than a glycoprotein D subunit vaccine

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Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection

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The herpes simplex virus type 1 UL20 protein and the amino terminus of glycoprotein K (gK) physically interact with gB.

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Exacerbation of corneal scarring in HSV-1 gK-immunized mice correlates with elevation of CD8+CD25+ T cells in corneas of ocularly infected mice

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Prevalence of herpes simplex virus type 2 infection, human immunodeficiency virus/herpes simplex virus type 2 coinfection, and associated risk factors in a national, population-based survey in Kenya

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CD8(+) T-cell attenuation of cutaneous herpes simplex virus infection reduces the average viral copy number of the ensuing latent infection

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Subtly impaired humoral immunity predisposes to frequently recurring genital herpes simplex virus type 2 infection and herpetic neuralgia

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A paradigm shift: vaccine-induced antibodies as an immune correlate of protection against herpes simplex virus type 1 genital herpes

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A replication competent HSV-1(McKrae) with a mutation in the amino-terminus of glycoprotein K (gK) is unable to infect mouse trigeminal ganglia after cornea infection

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Antibody-resistant mutations in cross-reactive and type-specific epitopes of herpes simplex virus 1 glycoprotein B map in separate domains

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T lymphocytes are required for protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2.

1 reference

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27 October 2018

The potential impact of a prophylactic herpes simplex vaccine

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune protection against HSV-2 in B-cell-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25350288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0109890

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22 February 2020

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22 February 2020

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22 February 2020

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