STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the central nervous system (Q34415819)

2 August 2017

title

STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the central nervous system (English)

1 reference

susceptibility to viral and mycobacterial infections

2 August 2017

1 reference

1 reference

Jianping Wang

1

1 reference

2 August 2017

Robert D Schreiber

series ordinal

2

1 reference

2 August 2017

Iain L Campbell

series ordinal

3

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2 August 2017

language of work or name

English

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publication date

2 December 2002

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Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

published in

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2 August 2017

volume

99

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2 August 2017

issue

25

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2 August 2017

page(s)

16209-16214

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Mutational switch of an IL-6 response to an interferon-gamma-like response

2 August 2017

cites work

1 reference

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Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction

6 July 2018

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Regulation of signal transducer and activator of transcription and suppressor of cytokine-signaling gene expression in the brain of mice with astrocyte-targeted production of interleukin-12 or experimental autoimmune encephalomyelitis

6 July 2018

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Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation

6 July 2018

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Interferon-independent, human immunodeficiency virus type 1 gp120-mediated induction of CXCL10/IP-10 gene expression by astrocytes in vivo and in vitro

6 July 2018

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An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons

6 July 2018

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Biologic consequences of Stat1-independent IFN signaling.

6 July 2018

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Stat1-independent regulation of gene expression in response to IFN-gamma

6 July 2018

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IFNalpha/beta promotes cell survival by activating NF-kappa B

6 July 2018

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Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines

6 July 2018

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Stat-1 is not essential for inhibition of B lymphopoiesis by type I IFNs

6 July 2018

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Mumps virus can suppress the effective augmentation of HPC-induced apoptosis by IFN-gamma through disruption of IFN signaling in U937 cells

6 July 2018

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6 July 2018

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Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase

6 July 2018

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6 July 2018

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Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha

6 July 2018

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C10 is a novel chemokine expressed in experimental inflammatory demyelinating disorders that promotes recruitment of macrophages to the central nervous system

6 July 2018

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Negative regulation of the JAK/STAT pathway

6 July 2018

1 reference

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How cells respond to interferons

6 July 2018

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Inhibition of Stat1-mediated gene activation by PIAS1

6 July 2018

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Interferon-alpha activates signal transducers and activators of transcription 5 and 6 in Daudi cells

6 July 2018

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The SOCS proteins: a new family of negative regulators of signal transduction

6 July 2018

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STAT3 complements defects in an interferon-resistant cell line: evidence for an essential role for STAT3 in interferon signaling and biological activities

6 July 2018

1 reference

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Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis

6 July 2018

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Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138590

A potential role for interferon-alpha in the pathogenesis of HIV-associated dementia.

6 July 2018

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Development of myasthenia gravis during interferon-alpha treatment for anti-HCV positive chronic hepatitis

6 July 2018

1 reference

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Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

6 July 2018

1 reference

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Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138590

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138590

Interferon expression in the testes of transgenic mice leads to sterility

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138590

Intrathecal synthesis of interferon-alpha in infants with progressive familial encephalopathy

6 July 2018

1 reference

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Central nervous system toxicity of interferons and other cytokines

6 July 2018

1 reference

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Interferons and their actions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138590

Development of type 1 diabetes mellitus during interferon alfa therapy for chronic HCV hepatitis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138590

Distinct requirements for IFNs and STAT1 in NK cell function

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.252454799

Interferons activate the p42/44 mitogen-activated protein kinase and JAK-STAT (Janus kinase-signal transducer and activator transcription factor) signalling pathways in hepatocytes: differential regulation by acute ethanol via a protein kinase C-dep

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.252454799

Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138590

Patterns of cytokine gene expression by CD4+ T cells from young and old mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138590

Immune response in Stat2 knockout mice

27 October 2018

1 reference

12 December 2020

Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox

1 reference

12 December 2020

Induction of type I diabetes by interferon-alpha in transgenic mice

1 reference

12 December 2020

Interferon expression in the pancreases of patients with type I diabetes

1 reference

12 December 2020

Development of transient autoimmune hepatitis during interferon treatment of chronic hepatitis B

1 reference

12 December 2020

Activation of the phosphatidylinositol 3-kinase serine kinase by IFN-alpha

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.252454799

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference